Association between serum urate levels and all-cause mortality, cardiovascular and renal outcomes among gout patients in Singapore DOI Creative Commons
Moses Yidong Lim, Weixiang Lian, Hwee Pin Phua

и другие.

BMC Rheumatology, Год журнала: 2024, Номер 8(1)

Опубликована: Дек. 20, 2024

We investigated the longitudinal association between Serum Urate (SU) level and Acute Myocardial Infarction (AMI), Stroke, End Stage Renal Failure (ESRF) all-cause mortality. conducted a retrospective hospital-based cohort study of individuals with gout managed in specialist outpatient clinics. Cox proportional hazards regression was used to estimate HR 95% CI, adjustments for potential confounders. Where hazard assumption violated, stratified applied instead. An acute care tertiary hospital Singapore. Individuals first diagnosis 2007–2017, identified through (i) primary discharge diagnosis, (ii) from Rheumatology SOC (iii) patient history clinical encounter at plus use urate-lowering therapy/colchicine. All-cause mortality, AMI, Stroke ESRF ascertained data linkage National Registry Diseases Office. The final comprised 2,866 individuals. Post follow-up, there were 800 deaths 362, 218 191 occurrences stroke respectively. Compared reference (second-lowest) SU quartile, being highest quartile associated significantly increased mortality (HR:1.66, CI:1.36–2.03), incident (HR:3.02, CI:2.00-4.56), AMI (HR:1.42, CI:1.06–1.91). p-trend all 3 outcomes significant. No significant found stroke. This that who had higher baseline levels an ESRF, AMI. Not applicable.

Язык: Английский

Association between serum urate levels and all-cause mortality, cardiovascular and renal outcomes among gout patients in Singapore DOI Creative Commons
Moses Yidong Lim, Weixiang Lian, Hwee Pin Phua

и другие.

BMC Rheumatology, Год журнала: 2024, Номер 8(1)

Опубликована: Дек. 20, 2024

We investigated the longitudinal association between Serum Urate (SU) level and Acute Myocardial Infarction (AMI), Stroke, End Stage Renal Failure (ESRF) all-cause mortality. conducted a retrospective hospital-based cohort study of individuals with gout managed in specialist outpatient clinics. Cox proportional hazards regression was used to estimate HR 95% CI, adjustments for potential confounders. Where hazard assumption violated, stratified applied instead. An acute care tertiary hospital Singapore. Individuals first diagnosis 2007–2017, identified through (i) primary discharge diagnosis, (ii) from Rheumatology SOC (iii) patient history clinical encounter at plus use urate-lowering therapy/colchicine. All-cause mortality, AMI, Stroke ESRF ascertained data linkage National Registry Diseases Office. The final comprised 2,866 individuals. Post follow-up, there were 800 deaths 362, 218 191 occurrences stroke respectively. Compared reference (second-lowest) SU quartile, being highest quartile associated significantly increased mortality (HR:1.66, CI:1.36–2.03), incident (HR:3.02, CI:2.00-4.56), AMI (HR:1.42, CI:1.06–1.91). p-trend all 3 outcomes significant. No significant found stroke. This that who had higher baseline levels an ESRF, AMI. Not applicable.

Язык: Английский

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