Selenium electrophilic center shuttles active electrons to boost mitochondrial electron leakage
Опубликована: Фев. 1, 2025
Язык: Английский
Combinatorial targeting of glutamine metabolism and lysosomal-based lipid metabolism effectively suppresses glioblastoma
Cell Reports Medicine,
Год журнала:
2024,
Номер
5(9), С. 101706 - 101706
Опубликована: Сен. 1, 2024
Язык: Английский
Selenium nanoparticles activate selenoproteins to mitigate septic lung injury through miR-20b-mediated RORγt/STAT3/Th17 axis inhibition and enhanced mitochondrial transfer in BMSCs
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Март 20, 2025
Sepsis-induced
acute
lung
injury
(ALI)
remains
a
critical
clinical
challenge
with
complex
inflammatory
pathogenesis.
While
bone
marrow
mesenchymal
stem
cells
(BMSCs)
demonstrate
therapeutic
potential
through
anti-inflammatory
and
cytoprotective
effects,
their
age-related
functional
decline
limits
utility.
This
study
developed
chitosan-functionalized
selenium
nanoparticles
(SeNPs@CS,
100
nm)
to
rejuvenate
BMSCs
miR-20b-mediated
selenoprotein
biosynthesis.
Mechanistic
investigations
revealed
that
SeNPs@CS-treated
exhibited
enhanced
mitochondrial
transfer
capacity,
delivering
mitochondria
damaged
alveolar
epithelial
(AECII)
for
cellular
repair.
Concurrently,
miR-20b
upregulation
suppressed
the
RORγt/STAT3/Th17
axis,
reducing
pro-inflammatory
Th17
cell
differentiation
in
CD4+
T
lymphocytes.
The
dual-target
mechanism
integrates
immunomodulation
via
pathway
inhibition
rejuvenation
therapy,
representing
paradigm-shifting
approach
ALI
management.
These
engineered
mitigated
markers
murine
models,
demonstrating
superior
efficacy
conventional
BMSC
therapies.
Our
findings
establish
SeNPs@CS-modified
as
novel
platform
combining
nanotechnology-enhanced
engineering
precision
immunometabolic
regulation,
providing
new
avenues
treatment
of
sepsis-induced
ALI.
Язык: Английский
Unraveling the nexus: Genomic instability and metabolism in cancer
Cell Reports,
Год журнала:
2025,
Номер
44(4), С. 115540 - 115540
Опубликована: Апрель 1, 2025
The
DNA-damage
response
(DDR)
is
a
signaling
network
that
enables
cells
to
detect
and
repair
genomic
damage.
Over
the
past
three
decades,
inhibiting
DDR
has
proven
be
an
effective
cancer
therapeutic
strategy.
Although
drugs
targeting
have
received
approval
for
treating
various
cancers,
tumor
often
develop
resistance
these
therapies,
owing
their
ability
undergo
energetic
metabolic
reprogramming.
Metabolic
intermediates
also
influence
cells'
sense
oxidative
stress,
leading
impaired
redox
metabolism,
thus
creating
vulnerabilities.
In
this
review,
we
summarize
recent
advances
in
understanding
crosstalk
between
metabolism.
We
discuss
combination
therapies
target
DDR,
vulnerabilities
cancer.
outline
potential
obstacles
metabolism
propose
strategies
overcome
challenges.
Язык: Английский
Exploring the Role of Thioredoxin system in Cancer Immunotherapy
Lin Sun,
Anni Yu,
Yang Yang
и другие.
Journal of Cancer,
Год журнала:
2024,
Номер
16(1), С. 66 - 80
Опубликована: Дек. 11, 2024
Purpose:
The
thioredoxin
(Trx)
system
is
integral
to
redox
regulation
and
participates
in
several
physiological
processes,
including
tumor
growth,
immune
response,
stem
cell
differentiation.
We
have
performed
a
comprehensive
holistic
analysis
of
the
Trx
immunity
this
study.
Methods:
A
study
using
Human
Protein
Atlas
(HPA)
Clinical
Proteomic
Tumor
Analysis
Consortium
(CPTAC)
databases
was
conducted
determine
expression
distribution
proteins.
To
explore
validate
correlation
between
levels
progression,
GTEx
TCGA
datasets
were
used.
Western
blotting
used
measure
lung
cancer
lines,
while
MTT
assays
proliferation.
Kaplan-Meier
plotter
database
association
survival
outcome
patients
pan-cancer.
GO
KEGG
enrichment
analyses
performed.
Next,
we
analyzed
how
related
activation.
Using
TIDE
TISMO
databases,
predicted
immunotherapy
responses.
Results:
An
abnormal
observed
cells.
Interference
with
siRNA
or
inhibitors
significantly
inhibits
suggesting
crucial
growth.
Through
broad
cohort
different
types,
explored
prominent
role
genes
system.
showed
relatively
consistent
aberrant
pan-cancer,
correlated
closely
clinical
prognosis.
Interestingly,
highly
prognosis
as
well
metabolism.
positively
associated
infiltration
decrease
survival.
also
response
immunotherapy.
Conclusion:
good
predictor
both
efficacy
immunotherapy,
Язык: Английский