Reprograming gene expression in “hibernating” C. elegans involves the IRE-1/XBP-1 pathway

Опубликована: Апрель 8, 2025

In nature, many animals respond to cold by entering hibernation, while in clinical settings, controlled cooling is used transplantation and emergency medicine. However, the molecular mechanisms that enable cells survive severe are still not fully understood. One key aspect of adaptation global downregulation protein synthesis. Studying it nematode Caenorhabditis elegans , we find translation most mRNAs continues cold, albeit at a slower rate, propose cold-specific gene expression regulated primarily transcription level. Supporting this idea, found certain cold-induced genes linked activation unfolded response (UPR) through conserved IRE-1/XBP-1 signaling pathway. Our findings suggest pathway triggered perturbations proteins lipids within endoplasmic reticulum, its beneficial for survival.

Язык: Английский

Reprograming gene expression in ‘hibernating’ C. elegans involves the IRE-1/XBP-1 pathway

eLife, Год журнала: 2025, Номер 13

Опубликована: Май 6, 2025

In nature, many animals respond to cold by entering hibernation, while in clinical settings, controlled cooling is used transplantation and emergency medicine. However, the molecular mechanisms that enable cells survive severe are still not fully understood. One key aspect of adaptation global downregulation protein synthesis. Studying it nematode Caenorhabditis elegans , we find translation most mRNAs continues cold, albeit at a slower rate, propose cold-specific gene expression regulated primarily transcription level. Supporting this idea, found certain cold-induced genes linked activation unfolded response (UPR) through conserved IRE-1/XBP-1 signaling pathway. Our findings suggest pathway triggered perturbations proteins lipids within endoplasmic reticulum, its beneficial for survival.

Язык: Английский

Reprograming gene expression in hibernatingC. elegansinvolves the IRE-1/XBP-1 pathway

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июль 19, 2024

ABSTRACT In nature, many animals respond to cold by entering hibernation, while in clinical settings, controlled cooling is used transplantation and emergency medicine. However, the molecular mechanisms that enable cells survive severe are still not fully understood. One key aspect of adaptation global downregulation protein synthesis. Studying it nematode Caenorhabditis elegans , we find translation most mRNAs continues cold, albeit at a slower rate, propose cold-specific gene expression regulated primarily transcription level. Supporting this idea, found certain cold-induced genes linked activation unfolded response (UPR) through conserved IRE-1/XBP-1 signaling pathway. Our findings suggest pathway triggered perturbations proteins lipids within endoplasmic reticulum, its beneficial for survival.

Язык: Английский