The multiple facets of Rab proteins modulating the cellular distribution of cholesterol from the late endosomal compartment

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Год журнала: 2025, Номер 1872(3), С. 119896 - 119896

Опубликована: Янв. 7, 2025

Язык: Английский

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Autophagy and Respiratory Viruses: Mechanisms, Viral Exploitation, and Therapeutic Insights

Cells, Год журнала: 2025, Номер 14(6), С. 418 - 418

Опубликована: Март 12, 2025

Respiratory viruses, such as influenza virus, rhinovirus, coronavirus, and respiratory syncytial virus (RSV), continue to impose a heavy global health burden. Despite existing vaccination programs, these infections remain leading causes of morbidity mortality, especially among vulnerable populations like children, older adults, immunocompromised individuals. However, the current therapeutic options for viral are often limited supportive care, underscoring need novel treatment strategies. Autophagy, particularly macroautophagy, has emerged fundamental cellular process in host response infections. This not only supports homeostasis by degrading damaged organelles pathogens but also enables xenophagy, which selectively targets particles degradation enhances defense. viruses have evolved mechanisms manipulate autophagy pathways, using them evade immune detection promote replication. review examines dual role manipulation defense, focusing on complex interplay between autophagy-related pathways. By elucidating mechanisms, we aim highlight potential targeting enhance antiviral responses, offering promising directions development effective treatments against

Язык: Английский

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3β-hydroxysteroid-Δ24 reductase integrates cholesterol metabolism and innate immune to promote PRRSV replication

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142867 - 142867

Опубликована: Апрель 1, 2025

Язык: Английский

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The inhibitory and anti-inflammatory effects of TMP269 on peste des petits ruminants virus replication

Virulence, Год журнала: 2025, Номер 16(1)

Опубликована: Апрель 24, 2025

Peste des petits ruminants (PPR) is an acute and fatal contagious disease, caused by the PPR virus (PPRV), one of most damaging animal diseases. The replication many viruses closely related to regulation histone deacetylases (HDACs). TMP269, a selective class IIa HDAC inhibitor, plays important role in cancer therapy also modulates viral replication. However, regulatory effects TMP269 on PPRV remain poorly understood. In this study, we employed western blotting, quantitative Real-time PCR (qRT-PCR), RNA sequencing (RNA-seq), enzyme-linked immunosorbent assay (ELISA) evaluate inhibitory anti-inflammatory Western blot analysis showed that treatment significantly suppressed Vero caprine endometrial epithelial cells (EECs). RNA-seq data revealed upregulation inflammatory response genes induced infection was markedly reversed TMP269. Further, qRT-PCR ELISA demonstrated decreased expression pro-inflammatory chemokines CCL2, CCL5, CCL7, CXCL8, cytokine IL-6 during infection, suggesting vital processes. Collectively, our findings suggest inhibitor promising antiviral agent for provides novel insights into abilities

Язык: Английский

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A complex remodeling of cellular homeostasis distinguishes RSV/SARS-CoV-2 co-infected A549-hACE2 expressing cell lines

Microbial Cell, Год журнала: 2024, Номер 11, С. 353 - 367

Опубликована: Окт. 8, 2024

Concurrent infections with two or more pathogens analogous tropism, such as RSV and SARS-CoV-2, may antagonize facilitate each other, modulating disease outcome. Clinically, discrepancies in the severity of symptoms have been reported children RSV/SARS-CoV-2 co-infection. Herein, we propose an

Язык: Английский

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