Optimization and purification of antimicrobial peptide HI produced by fermentation of Lactococcus lactis NZ9000/HI and its potential in pork preservation
LWT,
Год журнала:
2025,
Номер
unknown, С. 117342 - 117342
Опубликована: Янв. 1, 2025
Язык: Английский
The Role of Antimicrobial Peptides in Overcoming Antibiotic Resistance
The Microbe,
Год журнала:
2025,
Номер
unknown, С. 100337 - 100337
Опубликована: Апрель 1, 2025
Язык: Английский
Thymidylate Kinase-Targeted Antimicrobial Peptides via Phage Display: A Novel Strategy against Gram-Negative Bacteria
Journal of Medicinal Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 25, 2025
The
rise
of
antimicrobial
resistance
(AMR)
in
Gram-negative
bacteria,
including
Escherichia
coli
(E.
coli),
poses
a
major
public
health
threat.
This
study
aimed
to
address
the
limitations
existing
peptides
(AMPs)
by
designing
hybrid
with
enhanced
targeting
and
antibacterial
potency.
Eight
heptapeptide
sequences
were
identified
through
phage
display
screening
hybridized
WP
(WKKIWKPGIKKWIK),
peptide
exhibiting
weak
activity
against
bacteria.
systematically
evaluated
for
their
activity,
specificity,
biocompatibility.
SWP
exhibited
superior
particularly
E.
K88
(TI
=
2.378),
demonstrated
specific
binding
thymidylate
kinase
(TMK),
key
bacterial
enzyme.
In
vivo
studies
employing
mouse
peritonitis
model
confirmed
SWP's
ability
reduce
loads
mitigate
tissue
damage
while
maintaining
excellent
These
findings
underscore
as
promising
candidate
development
targeted
agents
specificity
stability
pathogens.
Язык: Английский
Characterization of the first antimicrobial peptide from Sea Seal with potent therapeutic effect in septic mice
Biochemical Pharmacology,
Год журнала:
2025,
Номер
unknown, С. 116891 - 116891
Опубликована: Март 1, 2025
Язык: Английский
Antimicrobial peptides: from discovery to developmental applications
Applied and Environmental Microbiology,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 3, 2025
Antimicrobial
resistance
(AMR)
has
emerged
as
a
significant
crisis
in
global
health.
Due
to
their
advantageous
properties,
antimicrobial
peptides
(AMPs)
have
garnered
considerable
attention
potential
alternative
therapy
address
the
AMR
crisis.
These
might
disrupt
cell
membranes
or
walls
exhibit
activity,
modulate
immune
response
promote
recovery
from
diseases.
In
recent
years,
progress
been
made
research
of
AMPs,
alongside
emergence
new
challenges.
This
review
first
systematically
summarizes
and
critically
discusses
advancements
understanding
characteristics
current
landscapes
well
regulatory
mechanisms
action
practical
applications,
particularly
those
reported
approved
within
last
5
years.
Additionally,
principles,
paths
for
identification,
future
trends
AMPs
are
also
analyzed
following
discussion
advantages
disadvantages
comparison
conventional
antibiotics.
Unlike
prior
literature
this
field,
report
summarized
latest
major
discovery
methods
and,
more
importantly,
emphasized
applications
by
supporting
various
viewpoints
using
selected
examples
AMPs'
real-life
scenarios.
Besides,
some
emerging
hot
topics
including
derived
gut
microbiota
synergistic
effects
combating
AMR,
were
profiled.
All
these
indicate
originality
provide
valuable
references
AMP
discoveries
applications.
Язык: Английский
Enhancement of Fluoride’s Antibacterial and Antibiofilm Effects against Oral Staphylococcus aureus by the Urea Derivative BPU
Jia Liu,
Qingqing Weng,
Dongxin Da
и другие.
Antibiotics,
Год журнала:
2024,
Номер
13(10), С. 930 - 930
Опубликована: Сен. 30, 2024
Background:
The
oral
cavity
is
an
important
but
often
overlooked
reservoir
for
Staphylococcus
aureus.
effective
control
and
prevention
of
S.
aureus
colonization
infection
in
the
maxillofacial
regions
are
crucial
public
health.
Fluoride
widely
used
dental
care
its
remineralization
antibacterial
properties.
However,
effectiveness
against
has
not
been
thoroughly
investigated.
Objectives:
This
study
aimed
to
evaluate
potential
combining
sodium
fluoride
(NaF)
with
compounds
enhance
antibiofilm
effects
Method:
We
found
that
a
urea
derivative
significantly
enhances
efficacy
by
promoting
retention
ions
within
cells.
synergistic
BPU
NaF
were
confirmed
through
various
assays,
including
checkerboard
time-kill
growth
curve
analysis.
These
findings
further
supported
additional
methods,
transmission
electron
microscopy
(TEM),
silico
simulations,
gene
overexpression
studies.
Results:
suggest
targeting
ion
membrane
exporters
could
efficacy.
When
combined
fluoride,
1,3-Bis
[3,5-bis(trifluoromethyl)phenyl]urea
(BPU)
showed
increased
inhibiting
reducing
established
biofilms.
Conclusions:
novel
combination
represents
promising
therapeutic
strategy
treating
biofilm-associated
infections,
offering
new
healthcare.
To
fully
clinical
this
therapy,
vivo
studies
essential.
Язык: Английский
Novel Tree Shrew-Derived Antimicrobial Peptide with Broad-Spectrum Antibacterial Activity
ACS Omega,
Год журнала:
2024,
Номер
9(45), С. 45279 - 45288
Опубликована: Окт. 30, 2024
The
number
of
cationic
residues
and
net
charge
are
critical
for
the
activity
antimicrobial
peptides
(AMPs)
due
to
their
role
in
facilitating
initial
electrostatic
interactions
with
negatively
charged
bacterial
membranes.
A
cathelicidin
AMP
(TC-33)
has
been
identified
from
Chinese
tree
shrew
our
previous
work,
which
exhibited
weak
activity,
likely
its
moderately
nature.
In
current
study,
based
on
TC-33,
we
designed
a
novel
by
peptide
truncation
Glu
substitutions
increase
+4
+8.
resulting
peptide,
TC-LAR-18,
showed
4-128-fold
enhanced
relative
TC-33
without
causing
hemolysis
cytotoxicity
within
100
μg/mL.
TC-LAR-18
effectively
eliminated
both
planktonic
biofilm-associated
bacteria,
demonstrating
rapid
bactericidal
effects
ability
quickly
penetrate
disrupt
cell
membranes
low
propensity
induce
resistance.
Notably,
provided
substantial
protection
against
skin
infection
mice,
underscoring
therapeutic
potential.
These
findings
not
only
highlight
importance
positively
antibacterial
AMPs
but
also
present
useful
drug
candidate
combating
multidrug-resistant
bacteria.
Язык: Английский
Identification of a novel antimicrobial peptide from amphioxus ribosomal protein L27
Fish & Shellfish Immunology,
Год журнала:
2024,
Номер
157, С. 110063 - 110063
Опубликована: Ноя. 30, 2024
Язык: Английский
Synergistic antimicrobial activity of alpha-linolenic acid in combination with tetracycline or florfenicol against multidrug-resistant Salmonella typhimurium
Microbial Pathogenesis,
Год журнала:
2024,
Номер
unknown, С. 106982 - 106982
Опубликована: Сен. 1, 2024
Язык: Английский
A Systematic Review of Aquatic Organism Antimicrobial Peptides
Pertanika journal of science & technology,
Год журнала:
2024,
Номер
32(6), С. 2847 - 2872
Опубликована: Окт. 23, 2024
Antimicrobial
peptides
(AMPs),
sourced
from
various
organisms,
including
aquatic
life,
are
promising
alternatives
to
combat
antibiotic
resistance.
Their
investigation
is
essential
amid
global
resistance
concerns.
The
invaluable
impact
of
antibiotics
on
human
health,
having
saved
numerous
lives,
currently
at
risk.
growing
incidence
antibiotic-resistant
bacteria
poses
a
serious
challenge
their
ability
effectively
treat
illnesses.
This
situation
demands
immediate
attention
and
the
exploration
alternative
medical
solutions.
One
most
antimicrobial
which
can
bacterial
infections,
particularly
those
brought
by
multi-drug-resistant
pathogens.
With
particular
focus
properties,
this
systematic
review
aims
evaluate
classify
recent
AMPs
isolated
organisms.
advances
knowledge
these
life-derived
AMPs’
potential
as
conventional
examining
unique
antibacterial
characteristics
modes
action.
A
articles
published
in
English
between
2014
2024
was
carried
out
Science
Direct,
PubMed
NCBI
Google
Scholar
databases
using
keywords
inclusion
exclusion
criteria.
total
33
organisms
had
been
reported,
21
were
reported
have
functional
activities.
Continuous
research
study
natural
substances,
AMPs,
remain
critical
pursuing
for
effective
treatments
combating
Therefore,
ongoing
holds
significant
importance
identifying
harnessing
future
applications.
Язык: Английский