Journal of Materials Chemistry A, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Triboelectric nanogenerator (TENG) is a promising method for capturing mechanical energy.
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(2), С. 709 - 709
Опубликована: Янв. 15, 2025
Nanozymes, a kind of nanoparticles with enzyme-mimicking activities, have attracted considerable attention due to their robust catalytic properties, ease preparation, and resistance harsh conditions. By combining nanozymes surface-enhanced Raman spectroscopy (SERS) technology, highly sensitive selective sensors been developed. These are capable detecting wide range analytes, such as foodborne toxins, environmental pollutants, biomedical markers. This review provides an overview recent advancements in the synthesis surface modification nanozymes, highlighting ability mimic multiple enzymes enhance performance. In addition, we explore development applications nanozyme-based SERS food contaminants, The concludes perspectives challenges facing field, involving need for deeper understanding nanozyme principles mechanisms, standardized systems characterization, engineering tailored properties specific applications. Finally, discuss potential integrating various techniques create multi-modal detection platforms, paving way next generation analytical tools fields safety, monitoring, diagnostics.
Язык: Английский
Процитировано
0
ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Фев. 5, 2025
Accurately and sensitively identifying killing cancer cells, especially those in deep tissues, is of paramount importance but presents significant challenges. Herein, a membrane protein adenosine triphosphate (ATP)-driven DNA logic gate-modified liposome designed to coat zinc peroxide (ZP) nanoparticles integrated with nanozymes (ZP/RuTe@L/DNA) accurately identify induce cell apoptosis cells through reactive oxygen species (ROS)-mediated mechanism under acid conditions cells. In this system, gate-functionalized liposomes are loaded ZP nanozymes, while HeLa functionalized segment that complementary the gate. For gate, aptamer was employed for recognition, another used response extracellular ATP. Activation gate occurs only when both biomarkers simultaneously present. Once activated, could hybridize segment-modified leading liposome-HeLa fusion release ZP/RuTe into Under conditions, decompose H2O2 Zn2+, which promote production •O2- by inhibiting electron transport chain. Concurrently, released RuTe exhibits glutathione (GSH) depletion peroxidase (POD) nicotinamide adenine dinucleotide (NADH) peroxidase-like activities, generating highly toxic hydroxyl radical (•OH), disrupting cellular redox homeostasis, inducing apoptosis. The ZP/RuTe@L/DNA system not detect complex mixtures also present novel method liposome-membrane processes drug delivery. This study potential application precise diagnosis therapy.
Язык: Английский
Процитировано
0
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Фев. 14, 2025
Abstract Piezoelectric semiconductor nanomaterials have attracted considerable interest in piezocatalytic tumor treatment. However, therapy encounters obstacles such as suboptimal piezoelectric responses, rapid electron‐hole recombination, inefficient energy harvesting, and the complexities of microenvironment. In this study, sulfur vacancy‐engineered cobalt (Co) single‐atom doped molybdenum disulfide (SA‐Co@MoS 2 ) nanoflowers are strategically designed, which exhibit enhanced effects. Specifically, introduction Co single atom not only induces lattice distortion out‐of‐plane polarization but also leads to formation numerous vacancies. These changes collectively narrow intrinsic bandgap material, facilitating effective separation migration charge carriers, enabling efficient production reactive oxygen species under ultrasound stimulation. Additionally, SA‐Co@MoS demonstrate improved enzymatic activity glutathione depletion capabilities attributed mixed valence states Co, intensifying oxidative stress cells, leading cell cycle arrest apoptosis, while inactivation peroxidase 4 ferroptosis. Both vitro vivo results indicate that can significantly eliminate cells. This study offers valuable insights into exploration doping‐enhanced sonosensitizers for cancer treatment, potentially paving way advancements field synergistic enzyodynamic therapy.
Язык: Английский
Процитировано
0
ACS Nano, Год журнала: 2025, Номер unknown
Опубликована: Март 7, 2025
Dual-atom nanozymes (DAzymes) have garnered considerable attention as catalysts for reactive oxygen species (ROS)-based therapies, effectively leveraging ROS generation within the tumor microenvironment (TME). Herein, we introduce FeMn-NCe DAzymes, which are meticulously engineered enhanced peroxidase (POD)-mimetic activity and potent radiosensitization to advance radioimmunotherapy. Density functional theory (DFT) calculations reveal that DAzymes lower energy barrier increase substrate affinity, enabling highly efficient catalytic performance. Within TME, these efficiently convert overexpressed hydrogen peroxide (H2O2) into hydroxyl radicals (•OH), potentially activating cGAS-STING immune pathway. This POD-mimetic catalysis is further accelerated under X-ray irradiation, significantly enhancing radiosensitization. Additionally, a uniform coating of ultrasmall gold nanoparticles on enhances absorption cancer cells. The incorporation STING agonist diABZI onto induces long-term antitumor immunity, reprograms immunosuppressive suppresses growth metastasis following single low-dose treatment. work highlights valuable strategy designing radiodynamic immunotherapy.
Язык: Английский
Процитировано
0
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 161355 - 161355
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Biomaterials, Год журнала: 2025, Номер unknown, С. 123288 - 123288
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Nano Today, Год журнала: 2025, Номер 63, С. 102747 - 102747
Опубликована: Апрель 7, 2025
Язык: Английский
Процитировано
0
ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Апрель 12, 2025
The development of piezoelectric biomaterials with the capability to produce electrical signals and scavenge reactive oxygen species (ROS) is a novel strategy for stimulating osteoblast responses promoting bone regeneration. Herein, tungsten (W), iridium (Ir), ruthenium (Ru) codoped bismuth molybdate (4(W/Ru/Ir)-BMO) nanosheets improved piezoelectricity enzyme-like (CAT-like SOD-like) activities were constructed by using hydrothermal method. A composite hydrogel oxidized sodium alginate/gelatin (OSA/GEL) 4(W/Ru/Ir)-BMO (OSA/GEL/4-B) was also prepared. Due presence 4(W/Ru/Ir)-BMO, OSA/GEL/4-B exhibited not only but activities. Under ultrasound (US), generated that significantly promoted proliferation osteogenic differentiation marrow stromal cells. Furthermore, effect CAT-like (production oxygen) SOD-like (scavenger ROS) attributed codoping W, Ir, Ru ions, which resulted in lattice distortion enhanced crystal asymmetry, produced regulating microenvironment. Moreover, improvement field triggered US accelerated electron transfer alleviating cellular oxidative stress provided an antioxidant microenvironment responses. This may provide pathway
Язык: Английский
Процитировано
0
Chinese Chemical Letters, Год журнала: 2025, Номер unknown, С. 111227 - 111227
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Journal of Materials Chemistry A, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Triboelectric nanogenerator (TENG) is a promising method for capturing mechanical energy.
Язык: Английский
Процитировано
1