Reviving-like prosocial behavior in response to unconscious or dead conspecifics in rodents
Science,
Год журнала:
2025,
Номер
387(6736)
Опубликована: Фев. 20, 2025
Whereas
humans
exhibit
emergency
responses
to
assist
unconscious
individuals,
how
nonhuman
animals
react
unresponsive
conspecifics
is
less
well
understood.
We
report
that
mice
stereotypic
behaviors
toward
or
dead
social
partners,
which
escalate
from
sniffing
and
grooming
more
forceful
actions
such
as
mouth
tongue
biting
pulling.
The
latter
intense
actions,
prominent
in
familiar
pairs,
begin
after
prolonged
immobility
unresponsiveness
cease
when
the
partner
regains
activity.
Their
consequences,
including
improved
airway
opening
clearance
accelerated
recovery
unconsciousness,
suggest
rescue-like
efforts.
Oxytocin
neurons
hypothalamic
paraventricular
nucleus
respond
differentially
presence
of
versus
active
their
activation,
along
with
oxytocin
signaling,
required
for
reviving-like
actions.
This
tendency
members
may
enhance
group
cohesion
survival
species.
Язык: Английский
Enhancement of neurogenesis and antidepressant-like efficacy through combined activation of Sigma-1 and 5-HT1A receptors: focus on Sigma-1-5-HT1A heteroreceptor complex
Neurochemistry International,
Год журнала:
2025,
Номер
unknown, С. 105937 - 105937
Опубликована: Янв. 1, 2025
Язык: Английский
Astrocytic pleiotrophin deficiency in the prefrontal cortex contributes to stress-induced depressive-like responses in male mice
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Март 14, 2025
Astrocytes
are
closely
linked
to
depression,
and
the
prefrontal
cortex
(PFC)
is
an
important
brain
region
involved
in
major
depressive
disorder
(MDD).
However,
underlying
mechanism
by
which
astrocytes
within
PFC
contribute
MDD
remains
unclear.
Using
single-nucleus
RNA
sequencing
analyses,
we
show
a
significant
reduction
attenuated
pleiotrophin-protein
tyrosine
phosphatase
receptor
type
Z1
(PTN-PTPRZ1)
signaling
astrocyte-to-excitatory
neuron
communication
of
male
patients.
We
find
reduced
PTN
dorsomedial
mice
with
depression
induced
chronic
restraint
social
defeat
stress.
Knockdown
astrocytic
induces
depression-related
responses,
reversed
exogenous
supplementation
or
overexpression
PTN.
The
antidepressant
effects
exerted
require
interaction
PTPRZ1
excitatory
neurons,
PTN-PTPRZ1
activates
AKT
pathway
regulate
responses.
Our
findings
indicate
PTN-PTPRZ1-AKT
may
be
potential
therapeutic
target
for
MDD.
but
mechanisms
remain
Here,
authors
that
pleiotrophin
contributes
depression-like
phenotype
mice.
Язык: Английский
Examining the role of the photopigment melanopsin in the striatal dopamine response to light
Frontiers in Systems Neuroscience,
Год журнала:
2025,
Номер
19
Опубликована: Апрель 2, 2025
The
mesolimbic
dopamine
system
is
a
set
of
subcortical
brain
circuits
that
plays
key
role
in
reward
processing,
reinforcement,
associative
learning,
and
behavioral
responses
to
salient
environmental
events.
In
our
previous
studies
the
dopaminergic
response
visual
stimuli,
we
observed
release
lateral
nucleus
accumbens
(LNAc)
mice
encoded
information
about
rate
magnitude
rapid
luminance
changes
from
darkness.
Light-evoked
were
rate-dependent,
robust
time
testing
or
stimulus
novelty,
required
phototransduction
by
rod
cone
opsins.
However,
it
unknown
if
these
also
involve
non-visual
opsins,
such
as
melanopsin,
primary
photopigment
expressed
intrinsically
photosensitive
retinal
ganglion
cells
(ipRGCs).
current
study,
evaluated
melanopsin
light
LNAc
using
genetically
sensor
dLight1
fiber
photometry.
By
measuring
light-evoked
across
broad
irradiance
wavelength
range
constitutive
(Opn4)
knockout
mice,
able
provide
new
insights
into
ability
opsins
regulate
stimuli.
Язык: Английский
From energy metabolism to mood regulation: The rise of lactate as a therapeutic target
Journal of Advanced Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Disruption
of
cerebral
energy
metabolism
is
increasingly
recognized
as
a
key
factor
in
the
pathophysiology
mood
disorders.
Lactate,
beyond
its
role
metabolic
byproduct,
now
understood
to
be
critical
player
brain
homeostasis
and
modulator
neuronal
function.
Recent
advances
understanding
lactate
shuttling
between
astrocytes
neurons
have
opened
new
avenues
for
exploring
multifaceted
roles
regulation.
Exercise,
known
modulate
levels,
further
underscores
potential
therapeutic
target
This
review
delves
into
alterations
associated
with
disorders,
emphasizing
their
implications
dynamics
signaling
pathways.
Additionally,
we
discuss
particularly
through
capacity
remodel
We
conclude
by
assessing
promise
exercise-induced
production
novel
strategy
disorder
treatment.
Alterations
may
contribute
pathogenesis
In
several
studies,
not
only
substrate
metabolism,
but
also
molecule
that
triggers
cascades.
Specifically,
involved
regulation
neurogenesis,
neuroplasticity,
endothelial
cell
function,
microglia
lysosomal
acidification,
therefore
improving
Meanwhile,
exercise
low-risk
intervention
can
improve
disorders
Thus,
evidence
from
this
supports
could
disorder,
contributing
deeper
intervention.
Язык: Английский