Sustainable Synthesis of Polyfluoro-Pyrimido [1,2-a] Benzimidazole Derivatives Using a Tandem Strategy─Ultrasound and an Integrated Continuous Flow System

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 6, 2025

We have developed a novel ultrasound technique that generates significant amounts of CF3-substituted benzo[4,5] imidazo [1,2-a]pyrimidine analogues from easily accessible starting materials in an ecologically friendly and efficient approach. This method is notably helpful for producing physiologically relevant compounds containing the imidazopyrimidine unit, which serves as versatile building block synthesis N-fused heterocycles devoid metals, solvents, additives, catalysts. Additionally, utilizing open-air environment, range polyfluoro-ynones were successfully reacted with 2-aminobenzimidazole, generating diverse array polyfluoroimidazo[1,2-a]pyrimidine derivatives. Furthermore, by employing integrated flow system approach, we able to synthesize polyfluoro-substituted benzo[4,5]imidazo[1,2-a]pyrimidine derivatives alkynes much shorter reaction time. Gram-scale proved this method's scalability highlighted its potential synthetic industrial applications. The straightforward nature process, broad compatibility various functional groups, substantial sustainability advantages collectively underscore significance.

Язык: Английский

Electrochemical Access to Difluoromethyl Groups: An Overview of Scope, Mechanisms, and Challenges

ACS Catalysis, Год журнала: 2025, Номер unknown, С. 6826 - 6851

Опубликована: Апрель 14, 2025

Язык: Английский