Therapeutic development to accelerate malaria control through intentional intervention layering
Malaria Journal,
Год журнала:
2025,
Номер
24(1)
Опубликована: Янв. 13, 2025
Язык: Английский
Screening the Resistance of Male Aedes aegypti and Anopheles coluzzii to Insecticides in the Context of Using Genetic Control Tools in Burkina Faso
Insects,
Год журнала:
2025,
Номер
16(3), С. 315 - 315
Опубликована: Март 18, 2025
Background:
Genetic
control
tools,
such
as
the
sterile
insect
technique
(SIT)
and
genetically
modified
mosquitoes
(GMMs),
require
releasing
males
comparable
to
their
wild
counterparts.
Ensuring
that
released
do
not
exhibit
higher
insecticide
resistance
is
critical.
This
study
assessed
phenotypic
characteristics
susceptibility
of
key
dengue
malaria
vector
species.
Methods:
Phenotypic
deltamethrin
(0.05%)
was
tested
in
two-to-five-day-old
male
female
Aedes
aegypti
(Linnaeus,
1762)
(Borabora
Bobo
strains)
Anopheles
coluzzii
(Coetzee
&
Wilkerson,
2013)
(Vallee
du
Kou
strain)
using
WHO
guidelines.
Wing
measurements
live
dead
were
used
assess
body
size.
Results:
Mortality
rates
similar
between
Ae.
(Bobo
An.
coluzzii,
while
Borabora
fully
susceptible
both
sexes.
Females
consistently
larger
than
males,
with
significantly
females
ones
strain.
Conclusion:
highlights
sex-specific
differences
size
susceptibility.
Integrating
these
analyses
into
management
programs
essential
for
success
sustainability
SIT-
GMM-based
interventions
targeting
vectors.
Implications
integrating
genetic
strategies
are
discussed.
Язык: Английский
Integrating malaria vaccine and CRISPR/Cas9 gene drive: a comprehensive strategy for accelerated malaria eradication
Malaria Journal,
Год журнала:
2025,
Номер
24(1)
Опубликована: Янв. 17, 2025
Malaria
remains
a
significant
public
health
challenge,
particularly
in
low-
and
middle-income
countries,
despite
ongoing
efforts
to
eradicate
the
disease.
Recent
advancements,
including
rollout
of
malaria
vaccines,
such
as
RTS,S/AS01
R21/Matrix-M™,
offer
new
avenues
for
prevention.
However,
rise
resistance
anti-malarial
medications
necessitates
innovative
strategies.
This
review
explores
potential
integration
CRISPR/Cas9
gene
drive
technology
with
vaccination
enhance
vector
control
reduce
transmission.
By
employing
mechanisms
population
suppression
replacement
malaria-transmitting
Anopheles
mosquitoes,
combined
immunogenic
properties
synergistic
approach
can
be
established.
paper
discussed
need
integrated
strategies
address
biological
complexities
socio-economic
factors
influencing
its
prevalence.
Challenges
regulatory
hurdles,
community
acceptance,
ecological
impacts,
sustainable
funding
are
examined,
alongside
implementation
within
existing
programmes.
could
significantly
contribute
achieving
World
Health
Organization's
targets
reduction
by
2030,
ultimately
enhancing
outcomes
supporting
broader
development.
Язык: Английский
Gene drive: communication, hype, and the publics
Journal of Medical Entomology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 7, 2025
Abstract
Engineered
gene
drive
(EGD)
systems
are
probably
the
most
high-tech
approach
considered
for
their
potential
role
in
control
of
vector-borne
diseases.
Interestingly,
rhetoric
around
it
often
goes
along
with
a
negative
presentation
current
“conventional”
tools
and
exaggerated
promises
about
EGD
themselves,
leading
to
situation
hype.
Язык: Английский
Meeting Report on the Symposium “Evolutionary Applications” at the 3rd Joint Congress on Evolutionary Biology
Evolutionary Applications,
Год журнала:
2025,
Номер
18(3)
Опубликована: Март 1, 2025
The
symposium
"Evolutionary
Applications"
took
place
on
June
28,
2024
in
the
virtual
part
of
3rd
Joint
Congress
Evolutionary
Biology.
It
was
contributed
to
conference
by
European
Society
for
Biology
(ESEB).
highlighted
research
evolutionary
biology
applied
address
questions
and
contemporary
problems
medicine
public
health,
conservation
biology,
food
production
agriculture.
Each
six
talks
covered
a
different
application
organism:
domestication
cheese-making
fungi,
restoration
long-lived
bird
populations,
evolution
herbicide
resistance,
coral
reef
conservation,
gene
drive
systems
targeting
Malaria
vectors,
antibiotic
resistance
bacteria.
By
including
speakers
who
are
active
consortium
or
work
an
NGO,
also
showed
how
make
step
from
scientific
findings
practical
application.
furthermore
featured
range
methods,
ranging
genomic
analyses
mathematical
modeling
laboratory
field
experiments.
Speakers
across
15
time
zones
potential
symposia
foster
global
collaboration
biology.
Язык: Английский
Problem formulation for a small-scale field study of non-gene drive, genetically modified, male bias mosquitoes in Burkina Faso
Human and Ecological Risk Assessment An International Journal,
Год журнала:
2025,
Номер
unknown, С. 1 - 39
Опубликована: Апрель 2, 2025
Язык: Английский