Changes of immune function mediated by Gasdermin-E in the immune microenvironment of primary oral squamous cell carcinoma

Oral Oncology, Год журнала: 2024, Номер 159, С. 107088 - 107088

Опубликована: Ноя. 4, 2024

Язык: Английский

Enhanced Photothermal/Immunotherapy under NIR Irradiation Based on Hollow Mesoporous Responsive Nanomotor

Inorganic Chemistry, Год журнала: 2024, Номер 64(1), С. 495 - 509

Опубликована: Дек. 27, 2024

In this research, a hollow mesoporous responsive nanomotor was proposed for enhanced photothermal/immunotherapy under near infrared (NIR) irradiation. HA-HMCuS/AS as the composed of copper sulfide (HMCuS) loaded with artesunate (AS) and hyaluronic acid (HA) utilized to induce polarization tumor-associated macrophages. At beginning, ResNet18 deep learning model predict Brunauer–Emmett–Teller (BET) surface area HMCuS based on morphology data set which obtained from our conventional research. And then, we predicted that as-synthesized has large area, is beneficial drug loading. Then, upon near-infrared light irradiation, exhibited significant cytotoxicity against breast cancer cells induced tumor thermal ablation. Additionally, found inhibit expression TREM2 at site, promoting transition M2-type macrophages M1-type in tissue enhancing inflammatory response site. addition, photothermal therapy enabled release antigen injury-related molecular patterns, promote maturation metastasis dendritic cells, further activate body's specific antitumor immune response. By combining immunotherapy, HA-HMCuS demonstrated even more robust ablation suppression effects.

Язык: Английский

Dual-template epitope imprinted nanoparticles for anti-glycolytic tumor-targeted treatment

Journal of Colloid and Interface Science, Год журнала: 2024, Номер 683, С. 890 - 905

Опубликована: Дек. 31, 2024

Язык: Английский