Artificial Intelligence-Powered Materials Science
Nano-Micro Letters,
Год журнала:
2025,
Номер
17(1)
Опубликована: Фев. 6, 2025
Abstract
The
advancement
of
materials
has
played
a
pivotal
role
in
the
human
civilization,
and
emergence
artificial
intelligence
(AI)-empowered
science
heralds
new
era
with
substantial
potential
to
tackle
escalating
challenges
related
energy,
environment,
biomedical
concerns
sustainable
manner.
exploration
development
are
poised
assume
critical
attaining
technologically
advanced
solutions
that
environmentally
friendly,
energy-efficient,
conducive
well-being.
This
review
provides
comprehensive
overview
current
scholarly
progress
intelligence-powered
its
cutting-edge
applications.
We
anticipate
AI
technology
will
be
extensively
utilized
material
research
development,
thereby
expediting
growth
implementation
novel
materials.
serve
as
catalyst
for
innovation,
turn,
advancements
innovation
further
enhance
capabilities
AI-powered
science.
Through
synergistic
collaboration
between
science,
we
stand
realize
future
propelled
by
Язык: Английский
Smart Microneedles in Biomedical Engineering: Harnessing Stimuli‐Responsive Polymers for Novel Applications
Polymers for Advanced Technologies,
Год журнала:
2024,
Номер
35(12)
Опубликована: Дек. 1, 2024
ABSTRACT
This
review
aims
to
provide
a
comprehensive
analysis
of
recent
advancements
in
smart
microneedles
(MNs)
within
the
biomedical
field,
focusing
on
integration
stimuli‐responsive
polymers
for
enhanced
therapeutic
and
diagnostic
applications.
Conventional
drug
delivery
methods
are
known
face
limitations
precision,
safety,
patient
compliance,
which
can
be
addressed
by
innovative
features
MNs.
Through
use
various
polymers,
these
MNs
have
been
designed
react
environmental
or
physiological
cues,
allowing
on‐demand
release,
biomarker
sensing,
localized
interventions.
Fundamental
materials
used
fabrication
MNs,
including
metals,
composite
hydrogels,
reviewed,
different
categories
stimuli‐responsiveness,
such
as
photo,
electro,
thermal,
mechanical,
biochemical,
explored.
Application‐specific
designs
areas
delivery,
cancer
therapy,
diabetes
management,
skin
disease
treatments
also
examined.
this
discussion,
it
is
highlighted
that
poised
play
significant
role
advancing
personalized
noninvasive
medical
treatments.
Язык: Английский
Living Microneedles for Intradermal Delivery of Beneficial Bacteria
Caroline Hali Alperovitz,
Noa Ben David,
Yuval Ramot
и другие.
ACS Biomaterials Science & Engineering,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 19, 2025
The
skin,
our
first
line
of
defense
against
external
threats,
combines
a
physical
barrier
and
rich
microbial
community.
Disruptions
this
community,
for
example,
due
to
infectious
injury,
have
been
linked
decrease
in
bacteria
diversity
mild
severe
pathological
conditions.
Although
some
progress
has
made
the
field,
possibilities/procedures
restoring
skin
microbiome
are
still
far
from
ideal.
objective
study
was
design
evaluate
dissolvable
poly(vinyl
alcohol)/polyvinylpyrrolidone
microneedle
(MN)
patch
containing
live
Bacillus
subtilis.
According
plan,
were
distributed
equally
throughout
without
compromising
morphology
mechanical
properties
needles.
B.
subtilis
successfully
released
MNs,
reaching
logarithmic
growth
phase
after
5
h.
These
MNs
demonstrated
remarkable
antibacterial
activity
Gram-positive
pathogenic
S.
pyogenes,
aureus,
C.
acnes,
while
empty
control
showed
no
such
activity.
Finally,
mice
inserted
with
single
MN
loaded
GFP-B.
presented
significantly
higher
total
radiance
efficiency
(TRE)
values
compared
empty-MN
entire
experiment.
This
concept
incorporating
live,
secreting
within
supportive
shows
great
promise
as
bacterial
delivery
system,
offering
potential
shift
conventional
pharmacological
approaches
more
sustainable
symbiotic
therapies.
Язык: Английский
Multi‐Functional Responsive Microcapsules with Sequential Release Capacity for Wound Healing
Small,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 26, 2025
Abstract
The
development
of
biomaterials
capable
on‐demand
delivery
holds
significant
promise
for
wound
therapy.
Current
research
is
centered
on
refining
design
precision
and
enhancing
structural
functionality
to
achieve
effective
controlled
release
active
agents,
thereby
facilitating
healing.
In
this
study,
a
coaxial
microfluidic
electrospray
technique
employed
fabricate
microcapsules
comprising
black
phosphorus
(BP)‐laden
alginate
shell
gelatin
methacrylate
(GelMA)
core.
Curcumin
nanoparticles
(CNPs)
vascular
endothelial
growth
factor
(VEGF)
are
respectively
incorporated
into
the
core
microcapsules.
photothermal
performance
contributed
superior
sterilization
efficacy
in
early
stages
healing,
while
factors
provided
robust
angiogenic
effects
during
later
stages.
These
attributes
enabled
significantly
accelerate
enhance
collagen
deposition,
modulate
inflammatory
responses
rat
model,
underscoring
their
potential
clinical
application.
Язык: Английский
Multifunctional Silk and Gelatin Composed Microneedle Patches for Enhanced Wound Healing
Smart Medicine,
Год журнала:
2025,
Номер
4(1)
Опубликована: Фев. 26, 2025
Wound
healing
has
been
a
continuous
critical
focus
in
clinical
practice,
posing
the
ongoing
challenges
and
burdens
to
patients.
Current
attempts
tend
develop
multi-drug
loaded
patches
with
spatial
design.
Herein,
we
present
multifunctional
microneedle
patch
that
integrates
different
drugs
into
separated
regions
for
wound
treatment.
The
is
composed
of
silk
fibroin-methacryloyl
(SilMA)
as
base,
silver
nanoparticles
(AgNPs)
gelatin
methacryloyl
(GelMA)
tips
vascular
endothelial
growth
factor
(VEGF).
backing
endowed
antimicrobial
properties
by
AgNPs
act
an
barrier
against
bacterium
invasion.
In
addition,
encapsulated
VEGF
can
effectively
promote
cell
proliferation
angiogenesis,
which
favorable
repair.
Based
on
these
characteristics,
such
integrated
system
significantly
prevented
bacterial
infection
promoted
vivo.
Therefore,
it
conceived
find
more
practical
values
other
fields.
Язык: Английский
A review on microneedle patch as a delivery system for proteins/peptides and their applications in transdermal inflammation suppression
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
307, С. 141963 - 141963
Опубликована: Март 12, 2025
Язык: Английский
Drug-loaded microneedle patches containing regulatory T cell-derived exosomes for psoriasis treatment
Meitong Ou,
Jiahui Cao,
Ran Luo
и другие.
Acta Biomaterialia,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Engineering pH and Temperature-Triggered Drug Release with Metal-Organic Frameworks and Fatty Acids
Molecules,
Год журнала:
2024,
Номер
29(22), С. 5291 - 5291
Опубликована: Ноя. 8, 2024
This
study
reports
the
successful
synthesis
of
core-shell
microparticles
utilizing
coaxial
electrospray
techniques,
with
zeolitic
imidazolate
framework-8
(ZIF-8)
encapsulating
rhodamine
B
(RhB)
in
core
and
a
phase
change
material
(PCM)
shell
composed
eutectic
mixture
lauric
acid
(LA)
stearic
(SA).
ZIF-8
is
well-recognized
for
its
pH-responsive
degradation
biocompatibility,
making
it
an
ideal
candidate
targeted
drug
delivery.
The
LA-SA
PCM
mixture,
melting
point
near
physiological
temperature
(39
°C),
enables
temperature-triggered
release,
enhancing
therapeutic
precision.
structural
properties
were
extensively
characterized
through
scanning
electron
microscopy
(SEM),
X-ray
diffraction
(XRD),
Fourier
transform
infrared
spectroscopy
(FTIR),
differential
calorimetry
(DSC),
thermogravimetric
analysis
(TGA).
Drug
release
studies
revealed
dual-stimuli
response,
where
RhB
was
significantly
influenced
by
both
pH.
Under
mildly
acidic
conditions
(pH
4.0)
at
40
°C,
rapid
complete
observed
within
120
h,
while
37
rate
notably
slower.
Specifically,
°C
79%
higher
than
confirming
sensitivity
system.
Moreover,
pH
(7.4),
minimal
occurred,
demonstrating
system's
potential
minimizing
premature
under
neutral
conditions.
approach
holds
promise
improving
outcomes
cancer
treatment
enabling
precise
control
over
response
to
localized
hyperthermia,
reducing
off-target
effects
patient
compliance.
Язык: Английский