MMPred: a tool to predict peptide mimicry events in MHC class II recognition DOI Creative Commons

Filippo Guerri,

Valentin Junet, Judith Farrés

и другие.

Frontiers in Genetics, Год журнала: 2024, Номер 15

Опубликована: Дек. 10, 2024

We present MMPred, a software tool that integrates epitope prediction and sequence alignment algorithms to streamline the computational analysis of molecular mimicry events in autoimmune diseases. Starting with two protein or peptide sets (e.g., from human SARS-CoV-2), MMPred facilitates generation, investigation, testing hypotheses by providing predictions specifically for MHC class II alleles, which are frequently implicated autoimmunity. However, is easily extendable I incorporating pre-trained models CNN-PepPred NetMHCpan. To evaluate MMPred's ability produce biologically meaningful insights, we conducted comprehensive assessment involving

Язык: Английский

Signaling Activation and Modulation in Extrafollicular B Cell Responses DOI Creative Commons
Julian Staniek, Marta Rizzi

Immunological Reviews, Год журнала: 2025, Номер 330(1)

Опубликована: Фев. 7, 2025

ABSTRACT The differentiation of naive follicular B cells into either the germinal center (GC) or extrafollicular (EF) pathway plays a critical role in shaping type, affinity, and longevity effector cells. This choice also governs selection survival autoreactive cells, influencing their potential to enter memory compartment. During first 2–3 days following antigen encounter, initially activated integrate activating signals from T Toll‐like receptors (TLRs), cytokines, alongside inhibitory mediated by receptors. integration modulates intensity signaling, particularly PI3K/AKT/mTOR pathway, which central guiding developmental decisions. These early signaling events determine whether undergo GC maturation differentiate rapidly antibody‐secreting (ASCs) via EF pathway. Dysregulation these pathways—whether through excessive activation defective regulatory mechanisms—can disrupt balance between fates, predisposing individuals autoimmunity. Accordingly, aberrant has been implicated increasing risk autoimmune disease. review focuses on newly with an emphasis induction regulation It highlights gaps our understanding how alternative cell fates are regulated. Both physiological context implications inborn errors immunity (IEIs) complex conditions will be discussed this regard.

Язык: Английский

Процитировано

0
Unveiling the Impact of COVID-19 on Ovarian Function and Premature Ovarian Insufficiency: A Systematic Review DOI Creative Commons
Charalampos Voros,

Despoina Mavrogianni,

Aspasia Minaoglou

и другие.

Biomedicines, Год журнала: 2025, Номер 13(2), С. 407 - 407

Опубликована: Фев. 7, 2025

Background/Objectives: Premature ovarian insufficiency (POI) is a disorder that affects women under the age of 40. It characterized by decreased function, elevated gonadotropin levels, and estradiol. SARS-CoV-2 disrupts function largely through oxidative stress, inflammation, immunological dysregulation, which are enhanced its entrance into tissues via ACE2 receptors. The purpose this comprehensive review was to investigate molecular pathways link infection POI analyze their consequences for reserve fertility. Methods: We searched databases such as PubMed, Scopus, EMBASE, Google Scholar papers published between 2020 2024. Eligible studies investigated effects on including hormonal indicators anti-Müllerian hormone (AMH) follicle-stimulating (FSH), oocyte quality, reserve. data were compiled complete examination molecules clinical findings. Increased inflammatory indicators, interleukin-6 NLRP3 inflammasome activation, impaired homeostasis. Anti-SARS-CoV-2 antibodies in follicular fluid could have quality. Observational showed transitory decreases AMH changed FSH levels following infection, with variable antral follicle count IVF results. Changes lipid profiles VEGF expression emphasized virus's influence angiogenesis microenvironment. Conclusions: impairs causing disruption, thereby increasing incidence POI. While most alterations temporary, long-term reproductive remain unknown. Continuous monitoring specific treatments required reduce risks associated COVID-19.

Язык: Английский

Процитировано

0
Analysis of 977 Long COVID Patients Reveals Prevalent Neuropathy and Association with Anti-Ganglioside Antibodies DOI Creative Commons
Cole Maguire,

Kristina Kashyap,

Elizabeth Matilda Oliveira Williams

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Март 5, 2025

Abstract Background Long COVID (LC) is a novel condition that characterized by persistent symptoms last from months to years following SARS-CoV-2 infection. While LC vary widely, neuropathy one of the most prevalent and drastically affects patients’ quality life. However, underlying pathophysiology remains poorly understood. Here, we investigated prevalence potential mechanisms in largest cohort date. Methods We conducted an observational study 977 adults with at Dell Medical School. Participants underwent clinical assessments, skin punch biopsy, comprehensive metabolic, endocrine immunological profiling. A subset patients received treatment intravenous immunoglobulin (IVIG). Findings Neuropathic were reported 55% (534/977) participants, biopsy confirming small fiber 56.5% (48/85) cases, affecting both epidermal autonomic nerve fibers. Common risk factors for neuropathy, including metabolic disorders, did not fully explain neuropathic symptoms. general markers (lymphocyte, T cell, B cell count C reactive protein unremarkable, unexpectedly, detected anti-ganglioside antibodies (AGAs) 25% comparable rate other AGA-associated neuropathies. Longitudinal testing revealed AGA positivity, multiple elevated AGAs patients. In pilot eight patients, IVIG resulted improvement patient Interpretation Our findings reveal high LC, evidence suggesting autoimmune mechanism involving four The therapeutic response further supports pathophysiology, benefits immunomodulation

Язык: Английский

Процитировано

0
Bacteriophage-Based Therapies in Oral Cancer: A New Frontier in Oncology DOI Creative Commons

Vishnu Priya Panneerselvam,

Leela Kagithakara Vajravelu,

Rahul Harikumar Lathakumari

и другие.

Cancer Pathogenesis and Therapy, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Rational design of a small peptidomimetic ligand to capture a viral spike protein DOI Creative Commons
Carlos Costa, Iana Lychko, Carolina M. Natal

и другие.

Separation and Purification Technology, Год журнала: 2025, Номер unknown, С. 132778 - 132778

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
MMPred: a tool to predict peptide mimicry events in MHC class II recognition DOI Creative Commons

Filippo Guerri,

Valentin Junet, Judith Farrés

и другие.

Frontiers in Genetics, Год журнала: 2024, Номер 15

Опубликована: Дек. 10, 2024

We present MMPred, a software tool that integrates epitope prediction and sequence alignment algorithms to streamline the computational analysis of molecular mimicry events in autoimmune diseases. Starting with two protein or peptide sets (e.g., from human SARS-CoV-2), MMPred facilitates generation, investigation, testing hypotheses by providing predictions specifically for MHC class II alleles, which are frequently implicated autoimmunity. However, is easily extendable I incorporating pre-trained models CNN-PepPred NetMHCpan. To evaluate MMPred's ability produce biologically meaningful insights, we conducted comprehensive assessment involving

Язык: Английский

Процитировано

0