Microbiome, Год журнала: 2025, Номер 13(1)

Опубликована: Апрель 29, 2025

Fusarium wilt, caused by oxysporum f. sp. cubense Tropical Race 4 (Foc TR4), poses a severe threat to global banana production. Secondary metabolites are critical tools employed pathogens interact with their environment and modulate host-pathogen dynamics. Bikaverin, red-colored polyketide pigment produced several species, has been studied for its pharmacological properties, but ecological roles impact on pathogenicity remain unclear. This study investigated the role of bikaverin in Foc TR4, focusing contribution interaction rhizosphere microbiome. Pathogenicity assays under sterile autoclaved conditions demonstrated that does not directly contribute affecting infection process or damaging host tissues. Instead, indirectly enhances TR4's reshaping It suppresses beneficial plant growth-promoting rhizobacteria, such as Bacillus, while promoting dominance fungal genera, thereby creating microbial pathogen colonization infection. Notably, biosynthesis was found be tightly regulated environmental cues, including acidic pH, nitrogen scarcity, competition. Co-culture microbes Bacillus velezensis Botrytis cinerea strongly induced production upregulated expression key biosynthetic gene FocBik1. In addition, identification bikaverin-resistant BR160, strain broad-spectrum antifungal activity, highlights potential biocontrol agent wilt management, although stability efficiency field require further validation. Bikaverin plays an indirect yet important TR4 manipulating function underscores target sustainable disease management strategies. Future research should focus elucidating molecular mechanisms underlying bikaverin-mediated interactions, using integrated approaches transcriptomics metabolomics. Together, these findings provide foundation novel combat enhance crop resistance. Video Abstract.

Язык: Английский