Fiber Type–Specific Adaptations to Exercise Training in Human Skeletal Muscle: Lessons From Proteome Analyses and Future Directions DOI Creative Commons
Morten Hostrup, Atul S. Deshmukh

Scandinavian Journal of Medicine and Science in Sports, Год журнала: 2025, Номер 35(5)

Опубликована: Апрель 25, 2025

ABSTRACT Skeletal muscle is a key determinant of sports performance. It highly specialized, yet complex and heterogeneous tissue, comprising multiple cell types. Muscle fibers are the main functional type responsible for converting energy into mechanical work. They exhibit remarkable ability to adapt in response stressors, such as exercise training. But while it recognized that human skeletal have distinct contractile metabolic features, classified slow/oxidative (type 1) or fast/glycolytic 2a/x), less attention has been directed adaptability different fiber Methodological advancements mass spectrometry‐based proteomics allow researchers quantify thousands proteins with only small amount tissue—even single fiber. By exploiting this technology, studies emerging highlighting subpopulations differently This review provides contemporary perspective on type–specific training humans. A aim our facilitate further within physiology by harnessing spectrometry proteomics.

Язык: Английский

Fiber Type–Specific Adaptations to Exercise Training in Human Skeletal Muscle: Lessons From Proteome Analyses and Future Directions DOI Creative Commons
Morten Hostrup, Atul S. Deshmukh

Scandinavian Journal of Medicine and Science in Sports, Год журнала: 2025, Номер 35(5)

Опубликована: Апрель 25, 2025

ABSTRACT Skeletal muscle is a key determinant of sports performance. It highly specialized, yet complex and heterogeneous tissue, comprising multiple cell types. Muscle fibers are the main functional type responsible for converting energy into mechanical work. They exhibit remarkable ability to adapt in response stressors, such as exercise training. But while it recognized that human skeletal have distinct contractile metabolic features, classified slow/oxidative (type 1) or fast/glycolytic 2a/x), less attention has been directed adaptability different fiber Methodological advancements mass spectrometry‐based proteomics allow researchers quantify thousands proteins with only small amount tissue—even single fiber. By exploiting this technology, studies emerging highlighting subpopulations differently This review provides contemporary perspective on type–specific training humans. A aim our facilitate further within physiology by harnessing spectrometry proteomics.

Язык: Английский

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