TRIM14 restricts tembusu virus infection through degrading viral NS1 protein and activating type I interferon signaling DOI Creative Commons
Peng Zhou, Qingxiang Zhang,

Yueshan Yang

и другие.

PLoS Pathogens, Год журнала: 2025, Номер 21(5), С. e1013200 - e1013200

Опубликована: Май 28, 2025

Tembusu virus (TMUV), an emerging avian orthoflavivirus, causes severe economic losses due to egg-drop syndrome and fatal encephalitis in domestic waterfowl. To combat this threat, the host immune system plays a crucial role controlling eliminating TMUV infection. Understanding mechanisms of response is thus vital for developing effective strategies against virus. In study, we investigated antiviral activities duck TRIM family proteins (duTRIM) TMUV, focusing particularly on duTRIM14 as potent restriction factor. We showed that overexpression significantly inhibits replication, while its deficiency leads increased viral titers. elucidate novel mechanism by which interacts with NS1 protein, facilitating K27/K29-linked polyubiquitination subsequent proteasomal degradation. The Lys141 residue was identified critical process, removal enhancing replication both vitro vivo . Furthermore, TBK1 (duTBK1), promoting K63-linked Lys30 Lys401, substantially augments IFN-β production during Taken together, these results provide dual-action suppresses simultaneously degradation modulating duTBK1 activity.

Язык: Английский

JEV NS1' protein enhances cell-to-cell viral spread by inducing the formation of tunneling nanotubes DOI

Ziyu Cao,

Shengda Xie,

Xingmiao Yang

и другие.

Veterinary Microbiology, Год журнала: 2025, Номер unknown, С. 110494 - 110494

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
The HAVCR1-centric host factor network drives Zika virus vertical transmission DOI Creative Commons
Wenzhe Yu,

Jun Tao,

Hongmin Cao

и другие.

Cell Reports, Год журнала: 2025, Номер 44(4), С. 115464 - 115464

Опубликована: Март 30, 2025

Язык: Английский

Процитировано

0
TRIM14 restricts tembusu virus infection through degrading viral NS1 protein and activating type I interferon signaling DOI Creative Commons
Peng Zhou, Qingxiang Zhang,

Yueshan Yang

и другие.

PLoS Pathogens, Год журнала: 2025, Номер 21(5), С. e1013200 - e1013200

Опубликована: Май 28, 2025

Tembusu virus (TMUV), an emerging avian orthoflavivirus, causes severe economic losses due to egg-drop syndrome and fatal encephalitis in domestic waterfowl. To combat this threat, the host immune system plays a crucial role controlling eliminating TMUV infection. Understanding mechanisms of response is thus vital for developing effective strategies against virus. In study, we investigated antiviral activities duck TRIM family proteins (duTRIM) TMUV, focusing particularly on duTRIM14 as potent restriction factor. We showed that overexpression significantly inhibits replication, while its deficiency leads increased viral titers. elucidate novel mechanism by which interacts with NS1 protein, facilitating K27/K29-linked polyubiquitination subsequent proteasomal degradation. The Lys141 residue was identified critical process, removal enhancing replication both vitro vivo . Furthermore, TBK1 (duTBK1), promoting K63-linked Lys30 Lys401, substantially augments IFN-β production during Taken together, these results provide dual-action suppresses simultaneously degradation modulating duTBK1 activity.

Язык: Английский

Процитировано

0