Blocking horizontal transfer of antibiotic resistance genes: an effective strategy in combating antibiotic resistance DOI
Pragyan Paramita Swain, Rajesh Kumar Sahoo

Critical Reviews in Microbiology, Год журнала: 2025, Номер unknown, С. 1 - 20

Опубликована: Апрель 10, 2025

Antimicrobial resistance (AMR) poses a significant public health threat, with emerging and novel forms of antibiotic genes (ARGs) resistant bacteria (ARB) potentially crossing international borders challenging the global systems. The rate development surpasses new antibiotics. Consequently, there is growing threat acquiring even to newer antibiotics further complicating treatment bacterial infections. Horizontal gene transfer (HGT) key mechanism for spread in through processes conjugation, transformation, transduction. Several compounds, other than antibiotics, have also been shown promote HGT ARGs. Given crucial role dissemination ARGs, inhibition strategy mitigate AMR. Therefore, this review explores contribution evolution, identifies specific hotspots andhighlights inhibitors impeding By specifically focusing on its inhibition, these offer highly promising approach combating

Язык: Английский

Blocking horizontal transfer of antibiotic resistance genes: an effective strategy in combating antibiotic resistance DOI
Pragyan Paramita Swain, Rajesh Kumar Sahoo

Critical Reviews in Microbiology, Год журнала: 2025, Номер unknown, С. 1 - 20

Опубликована: Апрель 10, 2025

Antimicrobial resistance (AMR) poses a significant public health threat, with emerging and novel forms of antibiotic genes (ARGs) resistant bacteria (ARB) potentially crossing international borders challenging the global systems. The rate development surpasses new antibiotics. Consequently, there is growing threat acquiring even to newer antibiotics further complicating treatment bacterial infections. Horizontal gene transfer (HGT) key mechanism for spread in through processes conjugation, transformation, transduction. Several compounds, other than antibiotics, have also been shown promote HGT ARGs. Given crucial role dissemination ARGs, inhibition strategy mitigate AMR. Therefore, this review explores contribution evolution, identifies specific hotspots andhighlights inhibitors impeding By specifically focusing on its inhibition, these offer highly promising approach combating

Язык: Английский

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