The interleukin gene landscape: understanding its influence on inflammatory mechanisms in apical periodontitis

Molecular Biology Reports, Год журнала: 2025, Номер 52(1)

Опубликована: Апрель 7, 2025

Язык: Английский

Two-year follow-up of gut microbiota alterations in patients after COVID-19: from the perspective of gut enterotype

Microbiology Spectrum, Год журнала: 2025, Номер unknown

Опубликована: Апрель 10, 2025

ABSTRACT Gut microbiota dysbiosis plays a role in the pathogenesis of post-acute coronavirus disease (COVID-19); however, long-term recovery gut following SARS-CoV-2 infection remains insufficiently understood. In this study, 239 fecal samples were collected from 87 COVID-19 patients during acute phase, and at 6 months, 1 year, 2 years post-discharge. An additional 48 non-COVID-19 controls also analyzed. enterotypes determined through 16S rRNA sequencing, dynamic changes phase assessed. Correlations between clinical characteristics examined. Two distinct identified: Blautia-dominated enterotype (Enterotype-B) Streptococcus-dominated (Enterotype-S). Species diversity richness significantly higher Enterotype-B. Enterotype-S, associated with inflammation, was more prevalent phase. Six months post-discharge, ratio Enterotype-B to Enterotype-S approached normal levels. Patients admission had incidence severe cases hospitalization longer duration nasopharyngeal viral shedding compared those Furthermore, residual pulmonary Computed Tomography (CT) abnormalities common (55%) than (20%, P = 0.046). index, B/S, representing Blautia Bifidobacterium Streptococcus, introduced found correlate closely characteristics. The is inflammation appears influence both severity illness cardiopulmonary recovery. IMPORTANCE This study sheds new light on intricate process rehabilitating disruptions caused by COVID-19. Our approach, which examines dynamics vantage point enterotypes, reveals rapid previously reported, majority rebounding within 6-month timeframe. our findings underscore importance as marker health, pivotal mitigating risk progression lingering effects post-SARS-CoV-2 infection. By scrutinizing these we can now foresee potential aftermath COVID-19, offering valuable tool for prognosis intervention.

Язык: Английский

Streptococcus anginosus: the potential role in the progression of gastric cancer

Journal of Cancer Research and Clinical Oncology, Год журнала: 2025, Номер 151(4)

Опубликована: Апрель 19, 2025

Gastric cancer (GC) is among the most common and aggressive malignancies worldwide, characterized by a poor prognosis. Research on its pathogenesis progression continues to evolve. Streptococcus anginosus (S. anginosus, SA) Gram-positive coccus commonly found in oral cavity upper respiratory tract, serving as commensal bacterium oral, gastrointestinal, genitourinary tracts. It frequently associated with abscess formation various organs tissues, well other purulent infections. In recent years, S. has gained increasing attention for role GC progression, potentially leading chronic gastric inflammation precancerous lesions, ultimately promoting development of GC. Emerging evidence indicates strong association between malignant unfavorable prognosis This review summarizes underlying mechanisms proposes that plays pivotal initiation underscoring potential therapeutic significance.

Язык: Английский