Frontiers in Neurology,
Год журнала:
2023,
Номер
14
Опубликована: Окт. 12, 2023
This
bibliometric
study
aimed
to
summarize
and
visualize
the
current
research
status,
emerging
trends,
hotspots
of
regulatory
T
(Treg)
cells
in
neurological
diseases.
Relevant
documents
were
retrieved
from
Web
Science
Core
Collection.
Tableau
Public,
VOSviewer,
CiteSpace
software
used
perform
analysis
network
visualization.
A
total
2,739
included,
on
Treg
diseases
is
still
a
prolific
period.
The
included
sourced
85
countries/regions,
with
majority
them
originating
United
States,
2,811
organizations,
significant
proportion
coming
Harvard
Medical
School.
Howard
E
Gendelman
was
most
author
this
area.
Considering
number
citations,
impact
factors,
JCR
partitions,
Frontiers
Immunology
popular
journal
Keywords
“multiple
sclerosis,”
“inflammation,”
“regulatory
cells,”
“neuroinflammation,”
“autoimmunity,”
“cytokines,”
“immunomodulation”
identified
as
high-frequency
keywords.
Additionally,
“gut
microbiota”
has
recently
emerged
new
topic
interest.
continues
be
hot
topic.
Immunomodulation,
gut
microbiota,
cytokines
represent
frontiers
field.
cell-based
immunomodulatory
approaches
have
shown
immense
potential
treatment
Modifying
microbiota
or
regulating
boost
numbers
functions
represents
promising
therapeutic
strategy
for
Journal of Neuroinflammation,
Год журнала:
2024,
Номер
21(1)
Опубликована: Янв. 4, 2024
Abstract
Background
Some
studies
have
shown
that
gut
microbiota
may
be
associated
with
dementia.
However,
the
causal
effects
between
and
different
types
of
dementia
whether
cytokines
act
as
a
mediator
remain
unclear.
Methods
Gut
microbiota,
cytokines,
five
types,
including
Alzheimer’s
disease
(AD),
frontotemporal
(FTD),
Lewy
body
(DLB),
vascular
(VD),
Parkinson’s
(PDD)
were
identified
from
large-scale
genome-wide
association
(GWAS)
summary
data.
We
used
Mendelian
randomization
(MR)
to
investigate
relationships
Inverse
variance
weighting
(IVW)
was
main
statistical
method.
In
addition,
we
explored
mediating
factor
in
pathway
Results
There
20
positive
16
negative
genetic
liability
Also,
there
four
dementias.
Cytokines
did
not
factors.
Conclusions
causally
dementia,
seemed
factors
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2024,
Номер
14
Опубликована: Фев. 16, 2024
Abnormal
behavior
of
α-synuclein
and
prion
proteins
is
the
hallmark
Parkinson’s
disease
(PD)
illnesses,
respectively,
being
complex
neurological
disorders.
A
primary
cause
protein
aggregation,
brain
injury,
cognitive
loss
in
illnesses
misfolding
normal
cellular
(PrP
C
)
into
an
infectious
form
Sc
).
Aggregation
causes
disruptions
processes
(PD),
leading
to
dopamine-producing
neurons
motor
symptoms.
Alteration
composition
or
activity
gut
microbes
may
weaken
intestinal
barrier
make
it
possible
for
prions
go
from
brain.
The
gut-brain
axis
linked
neuroinflammation;
metabolites
produced
by
microbiota
affect
aggregation
α-synuclein,
regulate
inflammation
immunological
responses,
influence
course
neurotoxicity
proteins,
even
if
their
targets
are
distinct
proteins.
This
thorough
analysis
explores
interactions
that
exist
between
neurodegenerative
particularly
involvement
microbiota,
a
collection
bacteria,
archaea,
fungi,
viruses
etc.,
various
becoming
increasingly
recognized.
microbiome
influences
neuroinflammation,
neurotransmitter
synthesis,
mitochondrial
function,
integrity
through
axis,
which
contributes
development
progression
disease.
review
delves
molecular
mechanisms
underlie
these
relationships,
emphasizing
effects
microbial
such
as
bacterial
lipopolysaccharides
(LPS),
short-chain
fatty
acids
(SCFAs)
regulating
functioning.
Additionally,
looks
at
how
environmental
dietary
decisions
whether
they
could
be
risk
factors
illnesses.
study
concludes
highlighting
critical
role
plays
It
also
provides
promising
direction
future
research
treatment
approaches.
People
afflicted
difficult
ailments
find
hope
new
preventive
therapeutic
approaches
diseases
better
understood.
Microbiology Research,
Год журнала:
2024,
Номер
15(2), С. 489 - 507
Опубликована: Апрель 5, 2024
The
human
gut
has
a
rich
and
dynamic
microbial
population
that
plays
an
important
role
in
many
physiological
activities.
This
review
explores
the
complex
interaction
between
microbiota
health,
with
emphasis
on
its
effect
neurodegenerative
illnesses.
makeup
of
microbiome
impact
brain
function
through
gut–brain
axis
is
highlighted.
Dysbiosis,
characterized
by
changes
microbiota’s
composition,
been
linked
to
development
diseases
such
as
Alzheimer’s,
Parkinson’s,
Huntington’s,
amyotrophic
lateral
sclerosis.
A
Bidirectional
communication
stomach
takes
place
via
variety
channels,
including
neurotransmitters
metabolites
generated
bacteria.
We
investigate
processes
which
dysbiosis
causes
neuroinflammation,
oxidative
stress,
neuronal
damage,
drive
disease
development.
Potential
therapeutic
approaches
focus
microbiota,
antibiotics,
probiotics,
prebiotics,
fecal
transplantation,
are
reviewed,
promising
preclinical
clinical
findings.
Overall,
this
study
emphasizes
relevance
illnesses,
well
need
understand
target
gut-brain
for
future
treatment
options.
npj Parkinson s Disease,
Год журнала:
2024,
Номер
10(1)
Опубликована: Май 21, 2024
Abstract
We
aimed
to
identify
gut
microbial
features
in
Parkinson’s
disease
(PD)
across
countries
by
meta-analyzing
our
fecal
shotgun
sequencing
dataset
of
94
PD
patients
and
73
controls
Japan
with
five
previously
reported
datasets
from
USA,
Germany,
China1,
China2,
Taiwan.
GC-MS
LC-MS/MS
assays
were
established
quantify
short-chain
fatty
acids
(SCFAs)
polyamines,
respectively.
α-Diversity
was
increased
six
datasets.
Taxonomic
analysis
showed
that
species
Akkermansia
muciniphila
PD,
while
Roseburia
intestinalis
Faecalibacterium
prausnitzii
decreased
PD.
Pathway
genes
the
biosyntheses
riboflavin
biotin
markedly
after
adjusting
for
confounding
factors.
Five
out
categories
carbohydrate-active
enzymes
(CAZymes)
Metabolomic
samples
revealed
SCFAs
polyamines
significantly
Genes
positively
correlated
concentrations
polyamines.
Bacteria
accounted
biosynthesis
Japan,
Germany
different
those
Similarly,
bacteria
two
country
groups.
postulate
reduce
intestinal
mucus
layer,
which
subsequently
facilitates
formation
abnormal
α-synuclein
fibrils
neural
plexus
also
cause
neuroinflammation
Journal of Neuroscience Research,
Год журнала:
2025,
Номер
103(1)
Опубликована: Янв. 1, 2025
Parkinson's
Disease
(PD)
is
a
neurodegenerative
disorder
marked
by
the
depletion
of
dopaminergic
neurons.
Recent
studies
highlight
gut-liver-brain
(GLB)
axis
and
its
role
in
PD
pathogenesis.
The
GLB
forms
dynamic
network
facilitating
bidirectional
communication
between
gastrointestinal
tract,
liver,
central
nervous
system.
Dysregulation
within
this
axis,
encompassing
gut
dysbiosis
microbial
metabolites,
emerging
as
critical
factor
influencing
progression.
Our
understanding
was
traditionally
centered
on
processes
brain.
However,
examining
through
lens
provides
new
insights.
This
review
comprehensive
analysis
such
short-chain
fatty
acids
(SCFAs),
trimethylamine-N-oxide
(TMAO),
kynurenine,
serotonin,
bile
acids,
indoles,
dopamine,
which
are
integral
to
pathogenesis
modulation
axis.
extensive
research
included
literature
database
searches
utilizing
resources
gutMGene
gutMDisorder.
These
databases
have
been
instrumental
identifying
specific
microbes
their
shedding
light
intricate
relationship
PD.
consolidates
existing
knowledge
underscores
potential
for
targeted
therapeutic
interventions
based
components,
offer
avenues
future
treatment
strategies.
While
not
novel
concept,
first
focus
specifically
PD,
highlighting
importance
integrating
liver
metabolites
players
puzzle.
