Nickel-mediated aerobic C(sp2)–nucleophile coupling reactions for late-stage diversification of aryl electrophiles
Nature Synthesis,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 16, 2025
Язык: Английский
Cross-Electrophile Coupling: Principles, Methods, and Applications in Synthesis
Chemical Reviews,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 26, 2024
Cross-electrophile
coupling
(XEC),
defined
by
us
as
the
cross-coupling
of
two
different
σ-electrophiles
that
is
driven
catalyst
reduction,
has
seen
rapid
progression
in
recent
years.
As
such,
this
review
aims
to
summarize
field
from
its
beginnings
up
until
mid-2023
and
provide
comprehensive
coverage
on
synthetic
methods
current
state
mechanistic
understanding.
Chapters
are
split
type
bond
formed,
which
include
C(sp
Язык: Английский
Reductive alkyl-alkyl coupling from isolable nickel-alkyl complexes
Nature,
Год журнала:
2024,
Номер
634(8034), С. 585 - 591
Опубликована: Авг. 29, 2024
Язык: Английский
Late-Stage C(sp2)–C(sp3) Diversification via Nickel Oxidative Addition Complexes
Journal of the American Chemical Society,
Год журнала:
2024,
Номер
146(31), С. 21264 - 21270
Опубликована: Июль 25, 2024
Herein,
we
describe
nickel
oxidative
addition
complexes
(Ni-OACs)
of
drug-like
molecules
as
a
platform
to
rapidly
generate
lead
candidates
with
enhanced
C(sp3)
fraction.
The
potential
Ni-OACs
access
new
chemical
space
has
been
assessed
not
only
in
C(sp2)–C(sp3)
couplings
but
also
additional
bond
formations
without
recourse
specialized
ligands
and
improved
generality
when
compared
Ni-catalyzed
reactions.
development
an
automated
diversification
process
further
illustrates
the
robustness
Ni-OACs,
thus
offering
gateway
expedite
design–make–test–analyze
(DMTA)
cycle
drug
discovery.
Язык: Английский
Trendbericht: Organische Chemie 2025
Nachrichten aus der Chemie,
Год журнала:
2025,
Номер
73(3), С. 40 - 70
Опубликована: Фев. 28, 2025
Abstract
Highlights
von
November
2023
bis
2024:
die
erste
Einelektron‐C–C‐σ‐Bindung
und
Anti‐Bredt‐Verbindung;
gesättigte
Heterocyclen
elektrochemisch
funktionalisieren;
Ausrichten
diskotischer
Flüssigkristalle;
enantioselektive
Wagner‐Meerwein‐Umlagerung
reiner
Aliphaten;
photokatalytisch
Furanen
zu
Pyrrolen;
mit
Ammoniak
primären
Arylaminen;
Metallschrott
recyceln
ionischen
Flüssigkeiten;
terminale
Alkene
Ni‐Katalysatoren
zum
(Z)‐
oder
(E)‐Alken
isomerisieren;neue
Fungizide,
Medikamente
Alkaloide.
Nickel-mediated aerobic Csp–nucleophile coupling
Trends in Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Язык: Английский
Reductive deaminative cross-coupling of alkyl bistriflimides enabled by electrocatalysis
Science Advances,
Год журнала:
2024,
Номер
10(47)
Опубликована: Ноя. 22, 2024
We
present
a
versatile
nickel-electrocatalytic
deaminative
cross-coupling
platform
for
the
efficient
construction
of
C(sp
3
)–C(sp
)
and
2
bonds
from
readily
available
alkyl
bistriflimides.
This
methodology
involves
assembly
two
leaving
groups
on
amines
to
form
bistriflimides,
followed
by
their
effective
coupling
with
wide
range
halides,
pseudohalides,
aryl
alkenyl
halides
under
electrochemical
reductive
conditions.
Moreover,
successful
application
relay
transition
metal–free
cross-electrophile
further
demonstrates
versatility
bistriflimides
as
valuable
building
blocks
in
organic
synthesis.
Combined
control
experiments
density
functional
theory
calculations
provide
insights
into
reaction
pathway
crucial
role
iodide
catalytic
process.
Язык: Английский