A swelling probe for nitric oxide

Nature Materials, Год журнала: 2025, Номер 24(1), С. 16 - 17

Опубликована: Янв. 1, 2025

Язык: Английский

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Selective magnetic resonance imaging of antibiotic-resistant bacteria leveraging ATP-binding cassette sugar transporter-responsive probes

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Янв. 10, 2025

Current magnetic resonance imaging (MRI) methods often fail to differentiate bacterial infections from nonbacterial inflammatory conditions because of their poor specificity. To address this limitation, we synthesized two MRI probes that exploit bacterial-specific ATP-binding cassette (ABC) sugar transporters for the selective delivery manganese porphyrin-based nanoparticles into antibiotic-resistant bacteria. These were via click chemistry by coupling azide-functionalized maltotriose with alkyne-modified hematoporphyrin, which formed self-assembling nanoparticles. Our studies revealed ~ 65% probe uptake in gram-positive and gram-negative bacteria, negligible (~ 1%) ABC transporter-deficient mutants. The demonstrated high longitudinal transverse relaxivities (up 11.56 mM⁻¹s⁻¹ 102.0 mM⁻¹s⁻¹, respectively), enabling ultrasensitive detection human-derived methicillin-resistant Staphylococcus aureus multidrug-resistant Escherichia coli at concentrations as low 10⁶ CFU. In murine models, differentiated nephritis inflammation visualized bacteria within tumour tissues, outperforming clinically used gadolinium-based agents. This study provides a promising approach precise deep tissues.

Язык: Английский

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Time-Resolved T1 and T2 Contrast for Enhanced Accuracy in MRI Tumor Detection

Biomaterials, Год журнала: 2025, Номер unknown, С. 123313 - 123313

Опубликована: Апрель 1, 2025

Язык: Английский

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Designing robust M–N–C single-atom catalysts for NOx sensing

Applied Physics Letters, Год журнала: 2025, Номер 126(14)

Опубликована: Апрель 1, 2025

Sensitive and selective detection of nitrogen oxides (NOx) is increasingly critical for both environmental protection human health. However, current detecting methods are based on metal oxide sensors, which greatly limited by issues high energy consumption, low selectivity, poor compatibility. Herein, we systematically explore the potential eleven experimentally available transition single atoms (M = Fe, Co, Ni, Cu, Ru, Rh, Pd, Ag, Ir, Pt, Au) embedded in nitrogen-doped graphene (M–N–C) NOx detection. It revealed that Ni–N–C exhibits exceptional selectivity sensitivity toward NOx, as evidenced preferable moderate adsorption strength significant changes microscopic electronic structures macroscopic current–voltage characteristics. Furthermore, applying proper external electric fields or strains enables to accelerate recovery Ni–N–C. This work highlights promising real-time monitoring offers valuable insight into application single-atom catalysts sensing.

Язык: Английский

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Nitric Oxide‐Mediated Dual‐Functional Smart Titanium Implant Coating for Antibacterial and Osseointegration Promotion in Implant‐Associated Infections

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 8, 2025

Abstract The balance of antibacterial and osseointegration‐promoting properties on titanium (Ti) implants in a simple efficient manner is crucial for the management implant‐associated infections, condition that has become significant global health concern. Herein, nitric oxide (NO)‐mediated dual‐function smart coating with developed Ti implants. leverages distinct NO at high low concentrations to enable an on‐demand functional switch. Specifically, function achieved through rapid release high‐dose response infection microenvironment near‐infrared stimulation. Once resolved normal physiological conditions are restored, gradually releases low‐dose promote osseointegration. In vitro tests confirm exhibits ratio 97.84% 97.18% against methicillin‐resistant Staphylococcus aureus its biofilms, respectively, demonstrates ability activate osteoblasts. rat femoral model further certifies responsive mechanism efficiently facilitates switch between properties. Notably, use dual‐functional nonantibiotic agent, NO, significantly mitigates risk bacterial resistance.

Язык: Английский

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Renal-Clearable Molecular Reporters for Near-Infrared Fluorescence Imaging and Urinalysis of Pulmonary Metastatic Tumor

Analytical Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 11, 2025

Despite approximately 40% of all patients with cancer developing pulmonary metastases in the course their disease, it remains a diagnostic challenge clinical practice. Herein, we propose fluorogenic probe (CPRG) gamma-glutamyl transferase (GGT)-triggered signal turn-on for near-infrared fluorescence imaging (NIRF) and urinalysis orthotopic metastatic tumors living mice. CPRG comprised four key moieties: GGT-reactive moiety, hemicyanine-based unit, polyethylene glycol linker, an active tumor targeting moiety. Such tailored is intrinsically nonfluorescent only activates its NIRF signals presence GGT. After intratracheal administration into lungs tumor-bearing mice, can efficiently accumulate sensitively real-time imaging. Relying on high renal clearance efficiency (∼70% ID), be rapidly excreted through kidneys assessed by chemotherapeutic efficacy cisplatin. This study not reports tracers but also provides guidelines development molecular probes companion diagnosis cancer.

Язык: Английский

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Ratiometric MRI probes for tumor microenvironment profiling: Design principles, multimodal validation, and future perspectives in precision oncology

Coordination Chemistry Reviews, Год журнала: 2025, Номер 537, С. 216709 - 216709

Опубликована: Апрель 17, 2025

Язык: Английский

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A Lifetime Nanosensor for In Vivo pH Quantitative Imaging and Monitoring

Small, Год журнала: 2025, Номер unknown

Опубликована: Апрель 23, 2025

Abstract Non‐invasive, in vivo quantitative imaging for long‐term biomarker monitoring is crucial elucidating disease mechanisms, advancing precision medicine, and transforming diagnostics therapeutic strategies. However, developing chemical sensors sustained despite sensor concentration fluctuations, excitation variability, tissue interference remains a major challenge. Here, long‐lifetime nanosensor based on lanthanide‐dye nanocomposite presented that overcomes these limitations, enabling precise pH monitoring. Benefiting from 64‐fold reversible change the dye's molar extinction coefficient, this enables dynamic tuning of non‐radiative energy transfer (RNET) efficiency (6.42%–35.23%) luminescence lifetime (265–383 µs). This 4 h gastrointestinal dynamics mice following proton pump inhibitor (PPI) administration, offering new insights into pharmacodynamic effects across different administration routes dosages inter‐individual variability drug efficacy. Moreover, coordination with lanthanide nanocrystals induces significant shift pK , highlighting importance nanomaterial interface engineering. work establishes versatile platform monitoring, marking step forward medicine.

Язык: Английский

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Hydrogen Sulfide-Responsive MRI Probe for Imaging Colon Cancer in Mice

Analytical Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 25, 2025

Hydrogen sulfide (H2S), a significant gaseous signaling molecule, is highly expressed in colon cancer. However, realizing sensitive and specific imaging of H2S deep cancer tissues remains an important challenge. In order to overcome this limitation, we have developed H2S-responsive magnetic probe (HRMP) with high sensitivity specificity. HRMP synthesized using superparamagnetic iron oxide Mn-porphyrin, coated hydrogen sulfide-responsive polymer. Upon reaction H2S, the released nanoparticles aggregate, producing enhanced transverse relaxivity (r2) through dipolar effect. Incorporation ortho azide group ensures that specifically responds reacting swiftly within 2 h induce change T2 relaxation time. Additionally, by precisely tuning feeding ratio Mn-porphyrin oxide, was endowed sensitivity, achieving detection limit as low 8.7 μM. studies HCT116 cancer, where overexpressed, generated distinct negative contrast at tumor site. shows potential for vivo offering promise early diagnosis tumors.

Язык: Английский

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Mechanically constrained into naivety

Nature Materials, Год журнала: 2024, Номер 23(12), С. 1620 - 1621

Опубликована: Ноя. 14, 2024

Язык: Английский

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