Tetraspanin Assemblies in Virus Infection

Frontiers in Immunology, Год журнала: 2018, Номер 9

Опубликована: Май 25, 2018

Tetraspanins are a family of four-span transmembrane proteins, known as plasma membrane 'master organizers'. They form tetraspanin-enriched microdomains (TEMs or TERMs) through lateral association with one another and other proteins. If multiple associate each other, larger platforms can form. For infection, viruses interact cell surface components including receptors, activating proteases, signaling molecules. It appears that tetraspanins such CD151, CD82, CD81, CD63, CD9, Tspan9, Tspan7 coordinate these associations by concentrating the interacting partners into tetraspanin platforms. In addition to mediating viral attachment entry, may also be involved in intracellular trafficking internalized assist defining virus assembly exit sites. conclusion, play role infection at different stages replication cycle. The present review highlights recently published data on this topic, focus events membrane. light findings, we propose model for how interactions organize cofactors distinct molecular

Язык: Английский

---

Single-cell epigenetic, transcriptional, and protein profiling of latent and active HIV-1 reservoir revealed that IKZF3 promotes HIV-1 persistence

Immunity, Год журнала: 2023, Номер 56(11), С. 2584 - 2601.e7

Опубликована: Ноя. 1, 2023

Язык: Английский

---

Hijacking of the Ubiquitin/Proteasome Pathway by the HIV Auxiliary Proteins

Viruses, Год журнала: 2017, Номер 9(11), С. 322 - 322

Опубликована: Окт. 31, 2017

The ubiquitin-proteasome system (UPS) ensures regulation of the protein pool in cell by ubiquitination proteins followed their degradation proteasome. It plays a central role under normal physiological conditions as well during viral infections. On one hand, UPS can be used to degrade proteins, thereby restricting infection. other it also subverted virus its own advantage, notably induce cellular restriction factors. This makes player and counter-restriction. In this respect, human immunodeficiency viruses (HIV-1 2) represent excellent examples. Indeed, many steps HIV life cycle are restricted some which themselves components UPS. However, itself hijacks mediate defense against several For example, auxiliary Vif, Vpx Vpu counteract specific factors recruitment components. review, we describe interplay between illustrate infections hijacking for

Язык: Английский

---

Interferons: Reprogramming the Metabolic Network against Viral Infection

Viruses, Год журнала: 2018, Номер 10(1), С. 36 - 36

Опубликована: Янв. 13, 2018

Viruses exploit the host and induce drastic metabolic changes to ensure an optimal environment for replication production of viral progenies. In response, has developed diverse countermeasures sense limit these alterations combat infection. One such mechanism is through interferon signaling. Interferons are cytokines that enhances transcription hundreds interferon-stimulated genes (ISGs) whose products key players in innate immune response addition their direct targeting components, interferons ISGs exert profound effects on cellular metabolism. Recent studies have started illuminate specific role rewiring metabolism activate cells This review reflects our current understanding complex networking occurs between virus at interface metabolism, with a focus particular, cholesterol-25-hydroxylase (CH25H), spermidine/spermine acetyltransferase 1 (SAT1), indoleamine-2,3-dioxygenase (IDO1) sterile alpha motif histidine/aspartic acid domain-containing protein (SAMHD1), which were recently discovered modulate events consequently deter

Язык: Английский

---

Tetraspanins interweave EV secretion, endosomal network dynamics and cellular metabolism

European Journal of Cell Biology, Год журнала: 2022, Номер 101(3), С. 151229 - 151229

Опубликована: Апрель 27, 2022

Tetraspanin proteins organize membrane nanodomains related to cell adhesion and migration. An essential feature conserved along the superfamily is their cone-shaped tertiary structure, which allows tetraspanins be enriched in highly curved structures. Their conical shape, together with ability associate transmembrane receptors bind cystoskeletal signaling scaffolds, are key regulate endosomal network dynamics Extracellular Vesicle biogenesis cargo selection. Recent evidence suggests that have a relevant impact mitochondria turnover regulation of cellular metabolism. In this review we highlight those reports point as regulators communication between network, EVs

Язык: Английский

---

Targeting of Tetraspanin CD81 with Monoclonal Antibodies and Small Molecules to Combat Cancers and Viral Diseases

Cancers, Год журнала: 2023, Номер 15(7), С. 2186 - 2186

Опубликована: Апрель 6, 2023

Tetraspanin CD81 plays major roles in cell-cell interactions and the regulation of cellular trafficking. This cholesterol-embarking transmembrane protein is a co-receptor for several viruses, including HCV, HIV-1 Chikungunya virus, which exploits large extracellular loop EC2 cell entry. also an anticancer target implicated cancer proliferation mobility, tumor metastasis. signaling contributes to development solid tumors (notably colorectal, liver gastric cancers) has been aggressivity B-cell lymphomas. A variety partners can interact with CD81, either regulate attachment uptake viruses (HCV E2, claudin-1, IFIM1) or contribute growth dissemination (CD19, CD44, EWI-2). CD81-protein be modulated molecules targeting domain investigated as antiviral and/or agents. Several monoclonal antibodies anti-CD81 have developed, notably mAb 5A6 active against invasion metastasis triple-negative breast cells. CD81-EC2 targeted natural products (trachelogenin harzianoic acids A-B) synthetic compounds (such benzothiazole-quinoline derivatives). They are weak binders but offer templates design new open loop. There no compound clinical at present, this structurally well-characterized tetraspanin warrants more substantial considerations drug target.

Язык: Английский

---

Dendritic Cells, the Double Agent in the War Against HIV-1

Frontiers in Immunology, Год журнала: 2019, Номер 10

Опубликована: Окт. 23, 2019

Human Immunodeficiency Virus (HIV) infects cells from the immune system and has thus developed tools to circumvent host immunity use it in its advance. Dendritic (DCs) are first encounter HIV, being main antigen (Ag) presenting cells, they link innate adaptive responses. While DCs work promote an efficient response halt infection, HIV-1 ways take advantage of their role uses gain faster more access CD4+ T cells. Due ability activate a specific response, promising candidates achieve functional cure but knowing molecular partakers that determine relationship between virus cell is key for rational successful design DC-based therapy. In this review, we summarize current state knowledge on how both DC subsets (myeloid plasmacytoid DCs) act presence HIV-1, focus different pathways can after binding DC. First, explore consequences recognition by each receptor DCs, including CD4 DC-SIGN. Second, look at cellular mechanisms prevent productive infection weapons turn defense into Trojan horse hides all way cell. Finally, discuss possible outcomes DC-T contact.

Язык: Английский

---

SAMHD1 Suppression of Antiviral Immune Responses

Trends in Microbiology, Год журнала: 2018, Номер 27(3), С. 254 - 267

Опубликована: Окт. 15, 2018

Язык: Английский

---

Tetraspanins: Host Factors in Viral Infections

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(21), С. 11609 - 11609

Опубликована: Окт. 27, 2021

Tetraspanins are transmembrane glycoproteins that have been shown increasing interest as host factors in infectious diseases. In particular, they were implicated the pathogenesis of both non-enveloped (human papillomavirus (HPV)) and enveloped immunodeficiency virus (HIV), Zika, influenza A virus, (IAV), coronavirus) viruses through multiple stages infection, from initial cell membrane attachment to syncytium formation viral particle release. However, mechanisms by which different tetraspanins mediate their effects vary. This review aimed compare contrast role life cycles HPV, HIV, IAV, coronavirus viruses, cause most significant health economic burdens society. doing so, a better understanding relative contribution infection will allow for more targeted approach treatment these

Язык: Английский

---

CD9 inhibition reveals a functional connection of extracellular vesicle secretion with mitophagy in melanoma cells

Journal of Extracellular Vesicles, Год журнала: 2021, Номер 10(7)

Опубликована: Май 1, 2021

Abstract Tetraspanins are often used as Extracellular Vesicle (EV) detection markers because of their abundance on these secreted vesicles. However, data function EV biogenesis controversial and compensatory mechanisms occur upon gene deletion. To overcome this handicap, we have compared the effects tetraspanin CD9 deletion with those elicited by cytopermeable peptides blocking properties against CD9. Both peptide or reduced number early endosomes. induced an increase in lysosome numbers, while augmented MVB secretion, probably CD63 expression upregulation. In vivo , delayed primary tumour cell growth metastasis size. These proliferation were shown to be concomitant impairment mitochondrial quality control. KO cells able compensate malfunction increasing total mass reducing mitophagy. Our thus provide first evidence for a functional connection mitophagy melanoma cells.

Язык: Английский

---