Interaction between microbiota and immunity in health and disease

Cell Research, Год журнала: 2020, Номер 30(6), С. 492 - 506

Опубликована: Май 20, 2020

Abstract The interplay between the commensal microbiota and mammalian immune system development function includes multifold interactions in homeostasis disease. microbiome plays critical roles training of major components host’s innate adaptive system, while orchestrates maintenance key features host-microbe symbiosis. In a genetically susceptible host, imbalances microbiota-immunity under defined environmental contexts are believed to contribute pathogenesis multitude immune-mediated disorders. Here, we review microbiome-immunity crosstalk their health disease, providing examples molecular mechanisms orchestrating these intestine extra-intestinal organs. We highlight aspects current knowledge, challenges limitations achieving causal understanding host immune-microbiome interactions, as well impact on diseases, discuss how insights may translate towards future microbiome-targeted therapeutic interventions.

Язык: Английский

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Gut microbiota-derived metabolites as key actors in inflammatory bowel disease

Nature Reviews Gastroenterology & Hepatology, Год журнала: 2020, Номер 17(4), С. 223 - 237

Опубликована: Фев. 19, 2020

Язык: Английский

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The Integrative Human Microbiome Project

Nature, Год журнала: 2019, Номер 569(7758), С. 641 - 648

Опубликована: Май 29, 2019

Abstract The NIH Human Microbiome Project (HMP) has been carried out over ten years and two phases to provide resources, methods, discoveries that link interactions between humans their microbiomes health-related outcomes. recently completed second phase, the Integrative Project, comprised studies of dynamic changes in microbiome host under three conditions: pregnancy preterm birth; inflammatory bowel diseases; stressors affect individuals with prediabetes. associated research begins elucidate mechanisms host–microbiome these conditions, provides unique data resources (at HMP Data Coordination Center), represents a paradigm for future multi-omic human microbiome.

Язык: Английский

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Microbial genes and pathways in inflammatory bowel disease

Nature Reviews Microbiology, Год журнала: 2019, Номер 17(8), С. 497 - 511

Опубликована: Июнь 27, 2019

Язык: Английский

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The microbiome and inflammatory bowel disease

Journal of Allergy and Clinical Immunology, Год журнала: 2020, Номер 145(1), С. 16 - 27

Опубликована: Янв. 1, 2020

Язык: Английский

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Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer

Gastroenterology, Год журнала: 2019, Номер 158(2), С. 322 - 340

Опубликована: Окт. 3, 2019

Язык: Английский

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Host–microbiota interactions in inflammatory bowel disease

Nature reviews. Immunology, Год журнала: 2020, Номер 20(7), С. 411 - 426

Опубликована: Янв. 31, 2020

Язык: Английский

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Impact of commonly used drugs on the composition and metabolic function of the gut microbiota

Nature Communications, Год журнала: 2020, Номер 11(1)

Опубликована: Янв. 17, 2020

The human gut microbiota has now been associated with drug responses and efficacy, while chemical compounds present in these drugs can also impact the bacteria. However, drug-microbe interactions are still understudied clinical context, where polypharmacy comorbidities co-occur. Here, we report relations between commonly used microbiome. We performed metagenomics sequencing of faecal samples from a population cohort two gastrointestinal disease cohorts. Differences users non-users were analysed per cohort, followed by meta-analysis. While 19 41 found to be microbial features, when controlling for use multiple medications, proton-pump inhibitors, metformin, antibiotics laxatives show strongest associations here provide evidence extensive changes taxonomy, metabolic potential resistome relation drugs. This paves way future studies implications current microbiome demonstrating need correct use.

Язык: Английский

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Bile acids and the gut microbiota: metabolic interactions and impacts on disease

Nature Reviews Microbiology, Год журнала: 2022, Номер 21(4), С. 236 - 247

Опубликована: Окт. 17, 2022

Язык: Английский

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Gut microbiota from green tea polyphenol-dosed mice improves intestinal epithelial homeostasis and ameliorates experimental colitis

Microbiome, Год журнала: 2021, Номер 9(1)

Опубликована: Сен. 7, 2021

Abstract Background Alteration of the gut microbiota may contribute to development inflammatory bowel disease (IBD). Epigallocatechin-3-gallate (EGCG), a major bioactive constituent green tea, is known be beneficial in IBD alleviation. However, it unclear whether exerts an effect when EGCG attenuates IBD. Results We first explored oral or rectal delivery on DSS-induced murine colitis. Our results revealed that anti-inflammatory and colonic barrier integrity were enhanced by oral, but not rectal, EGCG. observed distinct EGCG-mediated alteration microbiome increasing Akkermansia abundance butyrate production. Next, we demonstrated pre-supplementation induced similar outcomes administration. Prophylactic attenuated colitis significantly enriched short-chain fatty acids (SCFAs)-producing bacteria such as SCFAs production mice. To validate these discoveries, performed fecal transplantation (FMT) sterile filtrate (SFF) inoculate DSS-treated Microbiota from EGCG-dosed mice alleviated over control SFF shown superiorly integrity, also SCFAs. Collectively, attenuation suggests intimate involvement SCFAs-producing , SCFAs, which was further prophylaxis FMT. Conclusions This study provides data indicating ameliorated inflammation microbiota-dependent manner. findings provide novel insights into remission potential modulator for prevent treat

Язык: Английский

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