A systematic review of the association between history of sexually transmitted infections and subsequent condom use in adolescents

BMC Public Health, Год журнала: 2024, Номер 24(1)

Опубликована: Апрель 10, 2024

Abstract Sexually transmitted infections (STIs) are common among adolescents. According to the Health Belief Model, cues action influence preventive behaviors. Cues can include health experiences such as being diagnosed with an STI. The impact of a history STIs on subsequent condom use adolescents remains largely unexamined, despite high rates recurrence and their impacts. This project aimed systematically review literature association between curable systematic review, reported following PRISMA guidelines, was conducted using Joanna Briggs Institute method. Eligible studies, in form cohort case-control or cross-sectional targeted aged 10 24, without STIs; outcome use. MEDLINE (Ovid), Embase (Elsevier), Web Science were searched from January 2012 December 2022 assistance information specialist. Two reviewers independently selected articles extracted data. Risk bias analysis performed ROBINS-E. explores results, tables, based population characteristics, exposure, outcome, addresses gender, ethnicity, age. Of 3088 identified, seven studies retained. Almost all focused African-American, Nigerian, Rwandan adolescents, several included only girls. Among girls, STI increased combination other contraceptive methods ( n = 4). boys older both genders, associated decrease 3). No study distinguished different STIs. While 7) presented risk bias, six did not present threat conclusion validity. All indicated that could protective behaviors, possibly by acting cue action, posited Model. enhances our understanding factors leading adoption measures apply infectious experiences. Registration protocol is registered PROSPERO (CRD42023397443).

Язык: Английский

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Sequence, structure prediction, and epitope analysis of the polymorphic membrane protein family in Chlamydia trachomatis

PLoS ONE, Год журнала: 2024, Номер 19(6), С. e0304525 - e0304525

Опубликована: Июнь 11, 2024

The polymorphic membrane proteins (Pmps) are a family of autotransporters that play an important role in infection, adhesion and immunity Chlamydia trachomatis . Here we show the characteristic GGA(I,L,V) FxxN tetrapeptide repeats fit into larger repeat sequence, which correspond to coils large beta-helical domain high quality structure predictions. Analysis protein using prediction algorithms provided novel insight chlamydial Pmp proteins. While motifs themselves predicted structural folding close stacking backbone passenger domain, found many interesting features Pmps localized side loops jutting out from beta helix including protease cleavage, host cell adhesion, B-cell epitopes; while T-cell epitopes predominantly beta-helix itself. This analysis more accurately defines may better inform rational vaccine design functional studies.

Язык: Английский

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Microbiota and Recurrent Pregnancy Loss (RPL); More than a Simple Connection

Опубликована: Июль 9, 2024

Recurrent Pregnancy Loss (RPL) affects 1-2% of women, and its triggering factors are unclear. Several studies have shown the vaginal, endometrial, gut microbiota may play a role in RPL. A decrease quantity Lactobacillus crispatus local has been associated with an increase (vaginal endometrial) inflammatory response immune cell activation that leads to pregnancy loss. The be triggered by gram-negative bacteria, lipopolysaccharides (LPS), viral infections, mycosis, or atypia (tumor growth). Bacterial structures metabolites produced could involved modulation responsible for molecular mimicry. Gut metabolic products amount circulating pro-inflammatory lymphocytes, which, turn, will migrate into vaginal endometrial tissues. Local proinflammatory Th1 Th17 subpopulations along Treg tolerogenic NK cells accountable modulate increasing success. Analyzing necessary characterize some RPL patients. Although oral supplementation probiotics not modify microbiota, it benefit transplantation vagina enhance required achieve normal pregnancy. effect hormone stimulation progesterone maintain early on adequately studied, more research is needed this area. Well-designed clinical trials ascertain

Язык: Английский

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Microbiota and Recurrent Pregnancy Loss (RPL); More than a Simple Connection

Microorganisms, Год журнала: 2024, Номер 12(8), С. 1641 - 1641

Опубликована: Авг. 10, 2024

Recurrent Pregnancy Loss (RPL) affects 1–2% of women, and its triggering factors are unclear. Several studies have shown that the vaginal, endometrial, gut microbiota may play a role in RPL. A decrease quantity Lactobacillus crispatus local has been associated with an increase (vaginal endometrial) inflammatory response immune cell activation leads to pregnancy loss. The be triggered by gram-negative bacteria, lipopolysaccharides (LPS), viral infections, mycosis, or atypia (tumor growth). Bacterial structures metabolites produced could involved modulation responsible for molecular mimicry. Gut metabolic products amount circulating pro-inflammatory lymphocytes, which, turn, will migrate into vaginal endometrial tissues. Local Th1 Th17 subpopulations Treg tolerogenic NK cells accountable modulate response, increasing success. Analyzing necessary characterize some RPL patients. Although oral supplementation probiotics not modify microbiota, it benefit transplantation vagina enhance required achieve normal pregnancy. effect hormone stimulation progesterone maintain early on adequately studied, more research is needed this area. Well-designed clinical trials ascertain

Язык: Английский

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Trichomonas vaginalis and female reproductive health

Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 93 - 110

Опубликована: Янв. 1, 2025

Язык: Английский

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