Comparative Analysis of Vaccine-Induced Neutralizing Antibodies against the Alpha, Beta, Delta, and Omicron Variants of SARS-CoV-2

Vaccines, Год журнала: 2024, Номер 12(5), С. 515 - 515

Опубликована: Май 9, 2024

The SARS-CoV-2 virus has infected more than 660 million people and caused nearly seven deaths worldwide. During the pandemic, a number of vaccines were rapidly developed, several are currently licensed for use in Europe. However, optimization vaccination regimens is still ongoing, particularly with regard to booster vaccinations. At same time, emergence new variants poses an ongoing challenge vaccine efficacy. In this study, we focused on comparative analysis neutralization capacity vaccine-induced antibodies against four different concern (i.e., Alpha, Beta, Delta, Omicron) after two three doses COVID-19 vaccine. We able show that both (prime/boost) (prime/boost/boost) vaccinations elicit highly variable levels neutralizing antibodies. addition, did not observe significant difference antibody also observed decrease susceptibility all but one contrast, breakthrough infection between second third results overall higher concomitant improved variants. Titer remained across cohort common trend was observed. This may be due fact at time based exclusively wild-type SARS-CoV-2, whereas infections by Overall, our data demonstrate importance (booster) vaccinations, emphasize need continued adaptation induce protective immune response order prepared future (seasonal) outbreaks.

Язык: Английский

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Investigating the Antibody Imprinting Hypothesis among Canadian Paramedics after SARS-CoV-2 Omicron Variant Circulation

ImmunoHorizons, Год журнала: 2024, Номер 8(2), С. 193 - 197

Опубликована: Фев. 1, 2024

Abstract Recent research has highlighted the Omicron variant’s capacity to evade immune protection conferred by wild-type (WT) mRNA vaccines. Despite this observation, potential involvement of antigenic sin phenomena remains unclear. Our hypothesis posited that a greater number prior WT vaccine doses might lead reduced anti-Omicron neutralization Abs following infection. To investigate this, we analyzed blood samples from human participants in COVID-19 Occupational Risk, Seroprevalence, and Immunity among Paramedics (CORSIP) study who had received at least one before contracting Omicron. The exposure variable was vaccines administered, outcome angiotensin-converting enzyme 2 (ACE-2) percent inhibition specific BA.4/BA.5 Ag. Contrary expectations, our findings revealed more WT-based were associated with an enhanced Omicron-specific response.

Язык: Английский

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Effects of Strain Differences, Humidity Changes, and Saliva Contamination on the Inactivation of SARS-CoV-2 by Ion Irradiation

Viruses, Год журнала: 2024, Номер 16(4), С. 520 - 520

Опубликована: Март 28, 2024

One of the methods to inactivate viruses is denature viral proteins using released ions. However, there have been no reports detailing effects changes in humidity or contamination with body fluids on inactivation viruses. This study investigated and saliva efficacy SARS-CoV-2 ions multiple strains. Virus solutions different infectious titers were dropped onto a circular nitrocellulose membrane irradiated from 10 cm above membrane. After irradiation for 60, 90, 120 min, measured. The effect virus under conditions was also examined containing 90% mixtures collected people. A decrease infectivity observed over time all strains, but ion further accelerated infectivity. Ion can at 80% humidity, did not appear until 90 min after irradiation. presence protected drying maintained infectiousness longer period compared saliva. In particular, Omicron strain retained its titer than other demonstrated consistent reduction number when control across varying levels periods. underscores notable effectiveness irradiation, even as modest 50%, thereby emphasizing crucial role mitigating rapid dissemination SARS-CoV-2.

Язык: Английский

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Deceptive tactics: Misappropriation of scientific literature by ‘Gazeta do Povo’ in undermining COVID-19 vaccination efforts

Human Vaccines & Immunotherapeutics, Год журнала: 2024, Номер 20(1)

Опубликована: Май 2, 2024

Язык: Английский

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IL-2-mediated CD4 T-cell activation correlates highly with effective serological and T-cell responses to SARS-CoV-2 vaccination in people living with HIV (PLWH)

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Май 28, 2024

Abstract People living with HIV (PLWH) despite having appreciable depletion of CD4 + T-cell show a good SARS- CoV-2 vaccination response. The underlying mechanism(s) are currently not understood. We studied serological and polyfunctional responses in PLWH receiving anti-retroviral therapy stratified on counts as PLWH-high (CD4 ≥500 cells/μL) PLWH-low (<500 cells/μL). Responses were assessed longitudinally before the first (T0), 1-month after dose (T1), 3- months (T2), 6-months (T3) second dose. Expectedly, both -low groups developed similar T2, which also non-significantly different to age vaccination-matched HIV-negative controls at T3. IgG titers protective showing correlation ACE2-neutralizations (R=0.628, P=0.005). While no difference T3 was observed between activated CD154 memory T-cells, spike- specific cytokine expression analysis showed that preferentially express IL-2 (P<0.001) controls, IFN-γ (P=0.017). negatively correlated IL-2- expressing T-cells including (Spearman ρ: -0.85 -0.80, respectively; P<0.001). Our results suggest durable developing vaccinated associated IL-2-mediated activation likely compensates for PLWH.

Язык: Английский

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