Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 3, 2024
Abstract
Inflammatory
bowel
disease
(IBD)
is
an
idiopathic
gastrointestinal
with
drastically
increasing
incidence
rates.
Due
to
its
multifactorial
etiology,
a
precise
investigation
of
the
pathogenesis
extremely
difficult.
Although
reductionist
cell
culture
models
and
more
complex
in
animals
have
clarified
understanding
individual
mechanisms
contributing
factors
IBD
past,
it
remains
challenging
bridge
research
clinical
practice.
Conventional
2D
cannot
replicate
host–microbiota
interactions
stable
long‐term
microbial
culture.
Further,
extrapolating
data
from
animal
patients
due
genetic
environmental
diversity
leading
differences
immune
responses.
Human
intestine
organ‐on‐chip
(OoC)
emerged
as
alternative
vitro
model
approach
investigate
IBD.
OoC
not
only
recapitulate
human
intestinal
microenvironment
accurately
than
cultures
yet
may
also
be
advantageous
for
identification
important
disease‐driving
pharmacological
interventions
targets
possibility
emulating
different
complexities.
The
predispositions
biological
hallmarks
focusing
on
at
mucosal
barrier
are
elucidated
here.
Additionally,
potential
OoCs
explore
microbiota‐related
therapies
personalized
medicine
treatment
discussed.
