Chemical and Biophysical Signatures of the Protein Corona in Nanomedicine

Journal of the American Chemical Society, Год журнала: 2022, Номер 144(21), С. 9184 - 9205

Опубликована: Май 10, 2022

An inconvenient hurdle in the practice of nanomedicine is protein corona, a spontaneous collection biomolecular species by nanoparticles living systems. The corona dynamic composition and may entail improved water suspendability compromised delivery targeting to nanoparticles. How much this nonspecific ensemble determined chemistry nanoparticle core its surface functionalization, how entity dictated biological environments that vary spatiotemporally vivo? do we "live with" exploit without significantly sacrificing efficacy nanomedicines diagnosing curing human diseases? This article discusses chemical biophysical signatures ponders challenges ahead for field nanomedicine.

Язык: Английский

---

Macrophage Cell Membrane‐Cloaked Nanoplatforms for Biomedical Applications

Small Methods, Год журнала: 2022, Номер 6(8)

Опубликована: Июнь 29, 2022

Abstract Biomimetic approaches utilize natural cell membrane‐derived nanovesicles to camouflage nanoparticles circumvent some limitations of nanoscale materials. This emergent membrane‐coating technology is inspired by naturally occurring intercellular interactions, efficiently guide nanostructures the desired locations, thereby increasing both therapeutic efficacy and safety. In addition, intrinsic biocompatibility membranes allows crossing biological barriers avoids elimination immune system. results in enhanced blood circulation time lower toxicity vivo. Macrophages are major phagocytic cells innate They equipped with a complex repertoire surface receptors, enabling them respond signals, exhibit tropism inflammatory sites tumorous tissues. Macrophage membrane‐functionalized nanosystems designed combine advantages macrophages nanomaterials, improving ability those reach target sites. Recent studies have demonstrated potential these biomimetic for targeted delivery drugs imaging agents tumors, inflammatory, infected The present review covers preparation biomedical applications macrophage membrane‐coated nanosystems. Challenges future perspectives development addressed.

Язык: Английский

---

The effects of protein corona on in vivo fate of nanocarriers

Advanced Drug Delivery Reviews, Год журнала: 2022, Номер 186, С. 114356 - 114356

Опубликована: Май 17, 2022

Язык: Английский

---

Engineering nano-drug biointerface to overcome biological barriers toward precision drug delivery

Journal of Nanobiotechnology, Год журнала: 2022, Номер 20(1)

Опубликована: Авг. 31, 2022

Abstract The rapid advancement of nanomedicine and nanoparticle (NP) materials presents novel solutions potentially capable revolutionizing health care by improving efficacy, bioavailability, drug targeting, safety. NPs are intriguing when considering medical applications because their essential unique qualities, including a significantly higher surface to mass ratio, quantum properties, the potential adsorb transport drugs other compounds. However, must overcome or navigate several biological barriers human body successfully deliver at precise locations. Engineering carrier biointerface can help main optimize delivery in more personalized manner. This review discusses significant heterogeneous how engineering promote carriers prevail over hurdles manner, thus ushering era Precision Medicine. We also summarize nanomedicines' current advantages disadvantages administration, from natural/synthetic sources clinical applications. Additionally, we explore innovative NP designs used both non-personalized customized as well they attain therapeutic strategy.

Язык: Английский

---

Influence of surface chemistry and morphology of nanoparticles on protein corona formation

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Год журнала: 2022, Номер 14(4)

Опубликована: Март 7, 2022

Abstract Nanomaterials offer promising solutions as drug delivery systems and imaging agents in response to the demand for better therapeutics diagnostics. However, limited understanding of interaction between nanoparticles biological entities is currently hampering development new their applications clinical settings. Proteins lipids fluids are known complex with form a “biomolecular corona”. This has been shown affect particles' morphology behavior interactions cells. Hence, how nanomaterials' physicochemical properties formation composition this biocorona crucial step. work evaluates existing literature on (size shape), surface chemistry (charge hydrophobicity) influence protein corona. The latest evidence suggest that although charge promotes proteins lipids, plays leading role determining affinity nanoparticle biomolecules and, ultimately, More recently study additional nanoparticles' like shape chirality have demonstrated significant effect corona architecture, providing tools tailor biomolecular formation. article categorized under: Therapeutic Approaches Drug Discovery > Emerging Technologies Toxicology Regulatory Issues Nanomedicine

Язык: Английский

---

Current research trends of nanomedicines

Acta Pharmaceutica Sinica B, Год журнала: 2023, Номер 13(11), С. 4391 - 4416

Опубликована: Май 20, 2023

Owing to the inherent shortcomings of traditional therapeutic drugs in terms inadequate efficacy and toxicity clinical treatment, nanomedicine designs have received widespread attention with significantly improved reduced non-target side effects. Nanomedicines hold tremendous theranostic potential for treating, monitoring, diagnosing, controlling various diseases are attracting an unfathomable amount input research resources. Against backdrop exponentially growing number publications, it is imperative help audience get a panorama image activities field nanomedicines. Herein, this review elaborates on development trends nanomedicines, emerging nanocarriers, vivo fate safety their extensive applications. Moreover, challenges obstacles hindering translation nanomedicines also discussed. The elaboration aspects may enlighten readers set route future endeavors.

Язык: Английский

---

New opportunities and old challenges in the clinical translation of nanotheranostics

Nature Reviews Materials, Год журнала: 2023, Номер 8(12), С. 783 - 798

Опубликована: Июль 26, 2023

Язык: Английский

---

Cholesterol modulates the physiological response to nanoparticles by changing the composition of protein corona

Nature Nanotechnology, Год журнала: 2023, Номер 18(9), С. 1067 - 1077

Опубликована: Авг. 3, 2023

Язык: Английский

---

Biomedical Metal–Organic Framework Materials: Perspectives and Challenges

Advanced Functional Materials, Год журнала: 2023, Номер 34(43)

Опубликована: Ноя. 21, 2023

Abstract Metal–organic framework (MOF) materials are gaining significant interest in biomedical research, owing to their high porosity, crystallinity, and structural compositional diversity. Their versatile hybrid organic/inorganic chemistry endows MOFs with the capacity retain organic (drug) molecules, metals, gases, effectively channel electrons photons, survive harsh physiological conditions such as low pH, even protect sensitive biomolecules. Extensive preclinical research has been carried out treat several pathologies and, recently, integration other stents implants demonstrated promising performance regenerative medicine. However, there remains a gap between MOF translation into clinically societally relevant medicinal products. Here, intrinsic features of outlined suitability specific applications detoxification, drug gas delivery, or (combination) therapy platforms is discussed. Furthermore, examples how have engineered evaluated different medical indications, including cancer, microbial, inflammatory diseases described. Finally, challenges facing clinic critically examined, goal establishing directions more realistic approaches that can bridge translational MOF‐containing (nano)materials.

Язык: Английский

---

Continuous Spatiotemporal Therapy of A Full-API Nanodrug via Multi-Step Tandem Endogenous Biosynthesis

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Март 25, 2023

Abstract Nanomedicine holds great promise to enhance cancer therapy. However, low active pharmaceutical ingredient (API) loading content, unpredictable drug release, and potential toxicity from excipients limit their translational capability. We herein report a full-API nanodrug composed of FDA-approved 5-aminolevulinic acid (ALA), human essential element Fe 3+ , natural bioactive compound curcumin with an ideal API content pH-responsive release profile for continuous spatiotemporal therapy achieved by multi-step tandem endogenous biosynthesis. First, ALA enzymatically converts into photosensitizer protoporphyrin IX (PpIX). Afterward, multiple downstream products including carbon monoxide (CO), 2+ biliverdin (BV), bilirubin (BR) are individually biosynthesized through the PpIX-heme-CO/Fe /BV-BR metabolic pathway, further cooperating released curcumin, ultimately eliciting mitochondria damage, membrane disruption, intracytoplasmic injury. This work not only provides paradigm exploiting diversified metabolites tumor suppression, but also presents safe efficient nanodrug, facilitating practical translation nanodrugs.

Язык: Английский

---