Radiation-activated PD-L1 aptamer-functionalized nanoradiosensitizer to potentiate antitumor immunity in combined radioimmunotherapy and photothermal therapy

Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(47), С. 12220 - 12231

Опубликована: Янв. 1, 2024

This gold–MnO 2 nanoradiosensitizer enhances radioimmunotherapy by boosting ROS production, triggering immunogenic cell death, and effectively suppressing tumor growth metastasis.

Язык: Английский

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Organic probes for three‐photon fluorescence imaging in NIR‐II window: Design, applications, and perspectives

Interdisciplinary materials, Год журнала: 2024, Номер unknown

Опубликована: Окт. 7, 2024

Abstract Three‐photon fluorescence (3PF) imaging is an emerging technology for deep‐tissue submicroscopic structures by nonlinearly redshifting the excitation wavelength to second near‐infrared (NIR‐II) window; thus, this approach has great advantages, including deep penetration depth, good spatial resolution, low background, and a high signal‐to‐noise ratio. 3PF been demonstrated be powerful tool noninvasively visualizing all kinds of tissues in recent years. Benefiting from excellent biosecurity structural controllability, development organic probes highly important advancing vivo. However, there no summary generalizability design progress probes. Herein, review introduces fundamental principle highlights advantages bioimaging. The molecular these also summarized based on relative optical indices. Furthermore, different application scenarios are listed detail. In end, main challenges, significance probe exploitation, prospective orientation precise proposed discussed promoting future applications clinical translation.

Язык: Английский

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Recent Advances of Versatile Fluorophores for Multifunctional Biomedical Imaging in the NIR-II Region

Journal of Materials Chemistry B, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Fluorescence imaging in the second near-infrared region (NIR-II, 1000-1700 nm) enables high-resolution visualization of deep-tissue biological architecture and physiopathological events, due to reduced light absorption, scattering tissue autofluorescence. Numerous versatile NIR-II fluorescent probes have been reported over past decades. In this review, we first provide a detailed account advantages fluorescence region. Following this, classification, design performance optimization strategies are systematically discussed, along with broad range biomedical applications

Язык: Английский

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Advances in Lanthanide‐Based NIR‐IIb Probes for In Vivo Biomedical Imaging

Small Methods, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 9, 2024

Abstract The past decades have witnessed the significant development and practical interest of in vivo biomedical imaging technologies optical materials second‐near infrared (NIR‐II, 1000–1700 nm) window. Imaging with extended emission wavelength toward long‐wavelength end (NIR‐IIb, 1500–1700 further offers micrometer resolution centimeter tissue penetration depth by taking advantage much‐reduced photon scattering near‐zero autofluorescence background, which become a very hot research area. This review focuses on recent advances lanthanide‐based NIR‐IIb probes for applications. progress including ratiometric imaging, multiplexed wide‐field microscopy, lifetime multiplexing sensing, persistent luminescence, multimodal is summarized. Challenges future directions concerning investigation photophysical photochemical properties probes, selection near‐infrared cameras as well potential extension sub‐window are pointed out. will inspire readers who strong developing technology fluorescence high‐contrast

Язык: Английский

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Neutrophil elastase-activated carbon dots for non-invasive early diagnosis of inflammatory bowel disease by near-infrared-II fluorescence imaging

Chemical Engineering Journal, Год журнала: 2024, Номер unknown, С. 156099 - 156099

Опубликована: Сен. 1, 2024

Язык: Английский

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