Positively Charged Nanoplastics Destruct the Structure of the PCK1 Enzyme, Promote the Aerobic Gycolysis Pathway, and Induce Hepatic Tumor Risks

Environmental Science & Technology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 5, 2025

The production and weathering processes of nanoparticles (NPs) introduce charged functional groups on their surface. Previous studies have found that the surface charge properties NPs play a critical role in toxic effects mechanisms are generally attributed to different accumulations transmembrane potentials. Currently, we still lack sufficient knowledge about effects, owing unique structures these polymers. In this study, positively (PS-NH2, 50 nm) at 0.05-0.5 μg mL-1 promoted proliferation hepatic tumors oncogenic KrasG12V zebrafish larvae they also increased viability human hepatocellular carcinoma cells, whereas negatively (PS-COOH, did not. We present evidence indicating potential carcinogenicity PS-NH2 is related special polymer-molecular interactions caused by its positive charge. affinity PS-COOH chains for peptides typically enhances enzyme stability upregulates expression. However, strongly competes with hydrogen bonds first rate-limiting PCK1 gluconeogenesis, thus downregulating expression promoting aerobic glycolysis pathway, which most tumor cells prefer. This study indicates positive-charge modified environment may bring additional carcinogenic risks.

Язык: Английский

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Polystyrene Nanoplastics Hitch-Hike the Gut–Brain Axis to Exacerbate Parkinson’s Pathology

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Янв. 30, 2025

The neurological implications of micro- and nanoplastic exposure have recently come under scrutiny due to the environmental prevalence these synthetic materials. Parkinson's disease (PD) is a major disorder clinically characterized by intracellular Lewy-body inclusions dopaminergic neuronal death. These pathological hallmarks PD, according Braak's hypothesis, are mediated afferent propagation α synuclein (αS) via enteric nervous system, or so-called gut-brain axis. Here we first examined effect polystyrene nanoplastics on peripheral central pathogenesis A53T, representative αS mutant. Specifically, accelerated amyloid aggregation A53T αS, which subsequently elevated in vitro production glial activation biomarkers, cytokines, reactive oxygen species compromised mitochondrial lysosomal membrane integrity, further shifting cellular metabolite profiles association with PD pathophysiology. In vivo, coadministration facilitated their synergistic gut-to-brain transmission mice, leading progressive impairment physical motor skills resemblance characteristic symptoms. This study provides insights into response vulnerability axis nanoplastics.

Язык: Английский

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Nanoplastic-Induced Antibody Liquid-liquid Phase Separation: Insights into Potential Immunotoxic Implications

Journal of Hazardous Materials, Год журнала: 2025, Номер 487, С. 137170 - 137170

Опубликована: Янв. 9, 2025

Язык: Английский

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Revealing the removal behavior of polystyrene nanoplastics and natural organic matter by AlTi-based coagulant from the perspective of functional groups

Journal of Hazardous Materials, Год журнала: 2025, Номер 487, С. 137258 - 137258

Опубликована: Янв. 18, 2025

Язык: Английский

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Structural insights and milestones in TDP-43 research: A comprehensive review of its pathological and therapeutic advances

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 141677 - 141677

Опубликована: Март 1, 2025

Transactive response (TAR) DNA-binding protein 43 (TDP-43) is a critical RNA/DNA-binding involved in various cellular processes, including RNA splicing, transcription regulation, and stability. Mislocalization aggregation of TDP-43 the cytoplasm are key features pathogenesis several neurodegenerative diseases, amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), Alzheimer's disease (AD). This review provides comprehensive retrospective prospective analysis research, highlighting structural insights, significant milestones, evolving understanding its physiological pathological functions. We delineate five major stages from initial discovery as hallmark neurodegeneration to recent advances liquid-liquid phase separation (LLPS) behavior interactions with processes. Furthermore, we assess therapeutic strategies targeting pathology, categorizing approaches into direct indirect interventions, alongside modulating aberrant LLPS. propose that future research will focus on three areas: polymorphisms for disease-specific therapeutics, exploring dual temporal-spatial modulation TDP-43, advancing nano-therapy. More importantly, emphasize importance TDP-43's functional repertoire at mesoscale, which bridges molecular functions broader offers foundational framework development.

Язык: Английский

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Review of Techniques for the Detection, Removal, and Transformation of Environmental Microplastics and Nanoplastics

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Март 28, 2025

Plastic residues have emerged as a significant challenge in the environmental sector. Microplastics, which are plastic fragments smaller than 5 mm, ability to disperse through atmosphere, oceans, and land, posing serious threat human health by accumulating food chain. However, their minuscule size makes it difficult effectively remove them from environment using current technologies. This work provides comprehensive overview of recent advancements microplastic detection removal For methods, we discuss commonly used techniques such microscopic analysis, thermal mass spectrometry, spectroscopic energy spectrometry. We also emphasize importance integrating various analytical data-processing achieve efficient nondestructive microplastics. In terms strategies, explored innovative methods technologies for extracting microplastics environment. These include physical like filtration, adsorption, magnetic separation; chemical coagulation–flocculation–sedimentation photocatalytic conversion; bioseparation activated sludge biodegradation. highlight promising potential converting contaminants into high-value chemicals. Additionally, identify technical challenges suggest future research directions advocate development unified standardized guide further on transformation

Язык: Английский

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TDP-43 in nuclear condensates: where, how, and why

Biochemical Society Transactions, Год журнала: 2024, Номер 52(4), С. 1809 - 1825

Опубликована: Июль 3, 2024

TDP-43 is an abundant and ubiquitously expressed nuclear protein that becomes dysfunctional in a spectrum of neurodegenerative diseases. TDP-43's ability to phase separate form/enter biomolecular condensates varying size composition critical for its functionality. Despite the high density phase-separated assemblies nucleus abundance TDP-43, our understanding condensate-TDP-43 relationship this cellular compartment only emerging. Recent studies have also suggested misregulation condensation early event disease amyotrophic lateral sclerosis. This review aims draw attention facet functional aberrant condensation. We will summarise current knowledge on how containing form function their homeostasis affected disease.

Язык: Английский

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Uncovering the performance and intrinsic mechanism of different hydrolyzed AlTi species in polystyrene nanoplastics coagulation

Water Research, Год журнала: 2024, Номер unknown, С. 122440 - 122440

Опубликована: Сен. 1, 2024

Язык: Английский

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Organophosphate Insecticide Malathion Induces Alzheimer’s Disease-Like Cognitive Impairment in Mice: Evidence of the Microbiota-Gut-Brain Axis

Environmental Science & Technology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 15, 2024

Evidence suggests that exposure to organophosphate pesticides increases the risk of neurodegenerative diseases, but mechanisms remain unclear. This study investigated effects malathion on Alzheimer's disease (AD)-like symptoms at environmentally relevant concentrations using wild-type (WT) and APP/PS1 transgenic mouse models. Results showed induced AD-like cognitive impairment, amyloid-β (Aβ) accumulation, neuroinflammation in WT mice, with worsened mice. Mechanistic studies revealed gut microbiota dysbiosis (reduced Lactobacillus Akkermansia, increased Dubosiella), causing barrier impairment tryptophan metabolism disruptions. resulted a significant increase indole derivatives activation colonic aryl hydrocarbon receptor (AhR), promoting kynurenine (KYN) pathway while inhibiting serotonin (5-HT) pathway. Increased neurotoxic KYN metabolites (3-hydroxykynurenine quinolinic acid) triggered systemic inflammation, upregulating hippocampal IL-6 IL-1β mRNA levels thereby neuroinflammation. Gut disruptions caused neurotransmitter imbalances, reducing 5-HT its derivatives. These promoted AD progression both highlights crucial role microbiota-gut-brain axis by exposure, providing insights into risks posed pesticides.

Язык: Английский

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Polystyrene microplastics facilitate the chemical journey of phthalates through vegetable and aggravate phytotoxicity

Journal of Hazardous Materials, Год журнала: 2024, Номер unknown, С. 135770 - 135770

Опубликована: Сен. 1, 2024

Язык: Английский

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