Single-atom–doped piezocatalyst induces copper-free cuproptosis in tumor therapy

Science Advances, Год журнала: 2025, Номер 11(7)

Опубликована: Фев. 14, 2025

Cuproptosis, a distinct cell death pathway, has been integrated into nanomedicine for disease theranostics. However, current nanosystems inducing cuproptosis rely on exogenous toxic copper ions, limiting the scope of biomaterials. Developing nanoplatforms that induce without holds substantial promise. Here, we engineered two-dimensional iron (Fe) single-atom–doped molybdenum disulfide (MoS 2 ) piezocatalyst (Fe-MoS tumor therapy. Incorporating single Fe atoms enhances MoS piezoelectric polarization via charge redistribution and modulates Mo oxidation states, enabling multifaceted enzymatic activities, including peroxidase-, glutathione oxidase–, oxidase-, catalase-like activities. Upon ultrasound stimulation, Fe-MoS nanocatalyst generates reactive oxygen species depletes synergistic piezocatalytic enzyocatalytic effects, disrupting ion homeostasis cuproptosis, concurrently triggering ferroptosis ferritinophagy, which collectively suppression. This study represents first paradigm to introduce copper-free initiating substantially advancing applications in

Язык: Английский

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Anion exchange regulated charge separation engineering in bismuth nanoflowers for sonocatalytic radio-immunotherapy

Journal of Colloid and Interface Science, Год журнала: 2025, Номер 687, С. 801 - 816

Опубликована: Фев. 17, 2025

Язык: Английский

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Metal-based nanomedicines and their immunoregulatory effects

Chinese Science Bulletin (Chinese Version), Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Nitric Oxide‐Releasing Nanoscale Metal‐Organic Layer Overcomes Hypoxia and Reactive Oxygen Species Diffusion Barriers to Enhance Cancer Radiotherapy

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Abstract Hafnium (Hf)‐based nanoscale metal‐organic layers (MOLs) enhance radiotherapeutic effects of tissue‐penetrating X‐rays via a unique radiotherapy‐radiodynamic therapy (RT‐RDT) process through efficient generation hydroxy radical (RT) and singlet oxygen (RDT). However, their efficacy is limited by hypoxia in deep‐seated tumors short half‐lives reactive species (ROS). Herein the conjugation nitric oxide (NO) donor, S‐nitroso‐N‐acetyl‐DL‐penicillamine (SNAP), to Hf 12 secondary building units (SBUs) Hf‐5,5′‐di‐p‐benzoatoporphyrin MOL reported afford SNAP/MOL for enhanced cancer radiotherapy. Under X‐ray irradiation, efficiently generates superoxide anion (O 2 −. ) releases spatio‐temporally synchronized fashion. The released NO rapidly reacts with O form long‐lived highly cytotoxic peroxynitrite which diffuses freely cell nucleus causes DNA double‐strand breaks. Meanwhile, sustained release from tumor microenvironment relieves reduce radioresistance cells. Consequently, plus low‐dose irradiation inhibits growth reduces metastasis colorectal triple‐negative breast models.

Язык: Английский

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The therapeutic potential of nanoencapsulated anti-inflammatory drugs delivered to the gut

Nanomedicine, Год журнала: 2025, Номер unknown, С. 1 - 3

Опубликована: Фев. 5, 2025

Язык: Английский

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Cuproptosis Nanoprodrug-Initiated Self-Promoted Cascade Reactions for Postoperative Tumor Therapy

Biomaterials, Год журнала: 2025, Номер 318, С. 123176 - 123176

Опубликована: Фев. 7, 2025

Язык: Английский

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Progress in the Application of Nanomaterials for Radio Sensitization in Tumor Radiotherapy

Advances in Clinical Medicine, Год журнала: 2025, Номер 15(01), С. 1963 - 1971

Опубликована: Янв. 1, 2025

Язык: Английский

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Evolocumab attenuates myocardial ischemia/reperfusion injury by blocking PCSK9/LIAS-mediated cuproptosis of cardiomyocytes

Basic Research in Cardiology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 11, 2025

Язык: Английский

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Nanoenhanced‐Cuproptosis Results From the Synergy of Calcium Overload and GSH Depletion with the Increasing of Intracellular Ca/Mn/Cu Ions

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Фев. 10, 2025

Abstract Cuproptosis is a newly discovered copper‐dependent form of cell death. Intracellular glutathione (GSH) acts as copper chelator to inhibit cuproptosis, so the reduction GSH concentration conducive enhancing cuproptosis cells. In order reduce content and interfere with mitochondrial metabolism, strategy based on calcium overload depletion enhance proposed in this study. Containing manganese (Mn) (Cu) elements, CaCO 3 nanoparticles (NPs) are modified MCF‐7 aptamer (CaCO /Mn/Cu@lip‐Apt). When entering cell, /Mn/Cu@lip‐Apt decomposed released Mn* (Mn 2+ /Mn 3+ 4+ ), Cu Ca . The high valence Mn ion can effectively consume produce which catalyzed H 2 O reactive oxygen species (ROS), while reducing concentration. production ROS promoted influx exogenous large accumulation led intracellular overload, resulting dysfunction metabolism disorders. , turn triggered cuproptosis. This showed excellent antitumor effects provided new way study disease treatment.

Язык: Английский

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Immunogenic Cuproptosis in Cancer Immunotherapy via an In Situ Cuproptosis-Inducing System

Biomaterials, Год журнала: 2025, Номер 319, С. 123201 - 123201

Опубликована: Фев. 20, 2025

Язык: Английский

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