The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth

Cancer Cell, Год журнала: 2023, Номер 41(3), С. 374 - 403

Опубликована: Март 1, 2023

Язык: Английский

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Fibroblasts in cancer: Unity in heterogeneity

Cell, Год журнала: 2023, Номер 186(8), С. 1580 - 1609

Опубликована: Апрель 1, 2023

Язык: Английский

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Cancer organoids 2.0: modelling the complexity of the tumour immune microenvironment

Nature reviews. Cancer, Год журнала: 2024, Номер 24(8), С. 523 - 539

Опубликована: Июль 8, 2024

Язык: Английский

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Application of radiomics-based multiomics combinations in the tumor microenvironment and cancer prognosis

Journal of Translational Medicine, Год журнала: 2023, Номер 21(1)

Опубликована: Сен. 6, 2023

Abstract The advent of immunotherapy, a groundbreaking advancement in cancer treatment, has given rise to the prominence tumor microenvironment (TME) as critical area research. clinical implications an improved understanding TME are significant and far-reaching. Radiomics been increasingly utilized comprehensive assessment prognosis. Similarly, pathomics, which is based on pathological images, can offer additional insights into panoramic view microscopic information tumors. combination pathomics radiomics revolutionized concept “digital biopsy”. As genomics transcriptomics continue evolve, integrating with genomic transcriptomic datasets further heterogeneity establish correlations biological significance. Therefore, synergistic analysis digital image features (radiomics, pathomics) genetic phenotypes (genomics) comprehensively decode characterize well predict This review presents summary research important biomarkers for predicting TME, emphasizing interplay between radiomics, genomics, transcriptomics, application multiomics decoding Finally, we discuss challenges opportunities In conclusion, this highlights crucial role associations combined promising direction substantial significance value evaluation prognosis assessment.

Язык: Английский

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Multiphoton fluorescence microscopy for in vivo imaging

Cell, Год журнала: 2024, Номер 187(17), С. 4458 - 4487

Опубликована: Авг. 1, 2024

Язык: Английский

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Bridging live-cell imaging and next-generation cancer treatment

Nature reviews. Cancer, Год журнала: 2023, Номер 23(11), С. 731 - 745

Опубликована: Сен. 13, 2023

Язык: Английский

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Preclinical models for drug discovery for metastatic disease

Cell, Год журнала: 2023, Номер 186(8), С. 1792 - 1813

Опубликована: Апрель 1, 2023

Язык: Английский

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Brightness Strategies toward NIR-II Emissive Conjugated Materials: Molecular Design, Application, and Future Prospects

ACS Applied Bio Materials, Год журнала: 2024, Номер unknown

Опубликована: Апрель 1, 2024

Recent advances have been made in second near-infrared (NIR-II) fluorescence bioimaging and many related applications because of its advantages deep penetration, high resolution, minimal invasiveness, good dynamic visualization. To achieve high-performance NIR-II bioimaging, various materials probes with bright emission extensively explored the past few years. Among these emissive materials, conjugated polymers small molecules attracted wide interest due to their native biosafety tunable optical performance. This review summarizes brightness strategies available for highlights recent developments bioimaging. A concise, detailed overview molecular design regulatory approaches is provided terms brightness, long wavelengths, superior imaging Then, typical cases which are used as introduced by providing step-by-step examples. Finally, current problems challenges associated accessing briefly discussed, significance future prospects proposed offer helpful guidance development materials.

Язык: Английский

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The regulation of reporter transgene expression for diverse biological imaging applications

npj Imaging, Год журнала: 2025, Номер 3(1)

Опубликована: Март 4, 2025

Язык: Английский

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Emerging strategies to investigate the biology of early cancer

Nature reviews. Cancer, Год журнала: 2024, Номер 24(12), С. 850 - 866

Опубликована: Окт. 21, 2024

Язык: Английский

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