Engineering bioactive mineralized tumor cells for tumor immunotherapy DOI Creative Commons
Ziyang Shen, Yan He,

Ren Mo

и другие.

Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 13

Опубликована: Апрель 1, 2025

Introduction Whole-cell tumor vaccines are advantageous because of their ability to induce a broad and multifaceted immune response through the presentation wide range antigens, thereby enhancing system recognize target cancerous cells. Method In this study, we present multifunctional vaccine that consists manganese-mineralized cells positively charged polymer-immobilized CpG. The Mn 2+ CpG released from engineered facilitate maturation dendritic activation cGAS-STING TLR9 pathways, respectively. Result As consequence, derived B16F10 exhibited pronounced tumor-suppressive effect, reducing volume approximately one-fifth in control group, significantly extending survival day 30 tumor-bearing mice. This superior therapeutic outcome is associated with enhanced cells, increased infiltration NK CD8 + T production cytokines within microenvironment. Discussion Together, our study highlights immense potential engineering bioactive mineralized whole-cell vaccine-based immunotherapy.

Язык: Английский

Engineering bioactive mineralized tumor cells for tumor immunotherapy DOI Creative Commons
Ziyang Shen, Yan He,

Ren Mo

и другие.

Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 13

Опубликована: Апрель 1, 2025

Introduction Whole-cell tumor vaccines are advantageous because of their ability to induce a broad and multifaceted immune response through the presentation wide range antigens, thereby enhancing system recognize target cancerous cells. Method In this study, we present multifunctional vaccine that consists manganese-mineralized cells positively charged polymer-immobilized CpG. The Mn 2+ CpG released from engineered facilitate maturation dendritic activation cGAS-STING TLR9 pathways, respectively. Result As consequence, derived B16F10 exhibited pronounced tumor-suppressive effect, reducing volume approximately one-fifth in control group, significantly extending survival day 30 tumor-bearing mice. This superior therapeutic outcome is associated with enhanced cells, increased infiltration NK CD8 + T production cytokines within microenvironment. Discussion Together, our study highlights immense potential engineering bioactive mineralized whole-cell vaccine-based immunotherapy.

Язык: Английский

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