Adult skull bone marrow is an expanding and resilient hematopoietic reservoir DOI Creative Commons
Ralf H. Adams, Bong Ihn Koh, Vishal Mohanakrishnan

и другие.

Research Square (Research Square), Год журнала: 2023, Номер unknown

Опубликована: Окт. 26, 2023

Abstract The bone marrow microenvironment is a critical regulator of hematopoietic stem cell self-renewal and fate. While it appreciated that aging, chronic inflammation other insults compromise function thereby negatively affect hematopoiesis, not known whether different compartments exhibit distinct microenvironmental properties functional resilience. Here, we have employed imaging, pharmacological approaches, mouse genetics to uncover specialized highly surprising in adult aging skull. Specifically, show the skull undergoes lifelong expansion involving vascular growth, which results an increasing contribution total output. Furthermore, largely protected against major hallmarks including upregulation inflammatory cytokines, adipogenesis loss integrity. Striking dynamic rapid changes vasculature are induced by physiological alterations, namely pregnancy, but also pathological challenges, such as stroke experimental myeloid leukemia. These responses from femur, most extensively studied compartment. We propose harbors dynamically expanding microenvironment, relevant for studies but, potentially, clinical treatments humans.

Язык: Английский

Uncovering atherosclerotic cardiovascular disease by PET imaging DOI
Alexander Maier, Abraham J. P. Teunissen, Sheqouia A. Nauta

и другие.

Nature Reviews Cardiology, Год журнала: 2024, Номер 21(9), С. 632 - 651

Опубликована: Апрель 4, 2024

Язык: Английский

Процитировано

8
Haematometabolism rewiring in atherosclerotic cardiovascular disease DOI
Laurent Yvan‐Charvet, Thibault Barouillet, Coraline Borowczyk

и другие.

Nature Reviews Cardiology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 2, 2025

Язык: Английский

Процитировано

1
Cardiorespiratory effects of indoor ozone exposure during sleep and the influencing factors: A prospective study among adults in China DOI
Luyi Li,

Wenlou Zhang,

Shan Liu

и другие.

The Science of The Total Environment, Год журнала: 2024, Номер 924, С. 171561 - 171561

Опубликована: Март 6, 2024

Язык: Английский

Процитировано

7
Atherosclerosis and Bidirectional Relationship between Cancer and Cardiovascular Disease: From Bench to Bedside—Part 1 DOI Open Access

Giuseppina Gallucci,

Fabio Maria Turazza, Alessandro Inno

и другие.

Опубликована: Март 20, 2024

Atherosclerosis, a complex metabolic-immune disease characterized by chronic inflammation driven the buildup of lipid-rich plaques within arterial walls, has emerged as pivotal factor in intricate interplay between cancer and cardiovascular disease. This bidirectional relationship, marked shared risk factors pathophysiological mechanisms, underscores need for comprehensive understanding how these two formidable health challenges intersect influence each other. Cancer its treatments can contribute to progression atherosclerosis while with inflammatory microenvironment exert profound effects on development outcomes. Both involve interactions general personal exposomes. In this review we want summarize state-of-the-art translational data try show oncologic studies cardiotoxicity broaden our knowledge crucial pathways biology positive impact precision cardiology cardioncology.

Язык: Английский

Процитировано

4
Atherosclerosis and the Bidirectional Relationship between Cancer and Cardiovascular Disease: From Bench to Bedside—Part 1 DOI Open Access

Giuseppina Gallucci,

Fabio Maria Turazza, Alessandro Inno

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(8), С. 4232 - 4232

Опубликована: Апрель 11, 2024

Atherosclerosis, a complex metabolic-immune disease characterized by chronic inflammation driven the buildup of lipid-rich plaques within arterial walls, has emerged as pivotal factor in intricate interplay between cancer and cardiovascular disease. This bidirectional relationship, marked shared risk factors pathophysiological mechanisms, underscores need for comprehensive understanding how these two formidable health challenges intersect influence each other. Cancer its treatments can contribute to progression atherosclerosis, while with inflammatory microenvironment, exert profound effects on development outcomes. Both involve interactions general personal exposomes. In this review, we aim summarize state art translational data try show oncologic studies cardiotoxicity broaden our knowledge crucial pathways biology positive impact precision cardiology cardio-oncology.

Язык: Английский

Процитировано

4
Biomimetic/Bioderived Nanoengineered Interfaces for Biosensor Applications: A Review DOI
Jyotirmayee Sahoo, Riya Sharma, Vivek Pachauri

и другие.

ACS Applied Nano Materials, Год журнала: 2024, Номер 7(17), С. 19854 - 19875

Опубликована: Авг. 23, 2024

Nature inspires technological innovation through unique micronanostructured surfaces, such as fish fins, lotus leaves, butterfly wings, rose petals, a bird's spongy bone, etc. These structures exhibit capabilities beyond conventional engineering, making biomimetics key focus of scientific research. Integrating nanotechnology, biology, and bioengineering has significantly propelled the development nanomaterials with distinct functions properties. This interdisciplinary synergy extensively advanced biomimetic nanomaterials. review highlights nanomaterials, an emphasis on state-of-the-art sensing devices. In addition to this, it furnishes extensive compendium investigations into synthesis fabrication metal–organic frameworks (MOFs), molecularly imprinted polymers (MIPs), carbon-based (graphene, carbon nanotubes), gold nanoparticles (AuNPs), for biosensor development. We have focused their applications in disease diagnostics within healthcare while also addressing role environmental monitoring agriculture. comprehensive aims impart insightful understanding complexities associated these technologies concludes appraisal current challenges future developments.

Язык: Английский

Процитировано

4
Bone Marrow Niche in Cardiometabolic Disease: Mechanisms and Therapeutic Potential DOI
Zachary A. Kohutek, Heather L. Caslin, Daniel J. Fehrenbach

и другие.

Circulation Research, Год журнала: 2025, Номер 136(3), С. 325 - 353

Опубликована: Янв. 30, 2025

Cardiovascular and cardiometabolic diseases are leading causes of morbidity mortality worldwide, driven in part by chronic inflammation. Emerging research suggests that the bone marrow microenvironment, or niche, plays a critical role both immune system regulation disease progression. The niche is essential for maintaining hematopoietic stem cells (HSCs) orchestrating hematopoiesis. Under normal conditions, this ensures return to homeostasis after acute stress. However, setting inflammatory conditions such as those seen diseases, it becomes dysregulated, enhanced myelopoiesis activation. This review explores reciprocal relationship between highlighting how alterations contribute development regulates HSCs through complex interactions with stromal cells, endothelial signaling molecules. hypertension, atherosclerosis, diabetes, signals disrupt balance HSC self-renewal differentiation, promoting excessive production proinflammatory myeloid exacerbate disease. Key mechanisms discussed include effects hyperlipidemia, hyperglycemia, sympathetic nervous activation on proliferation differentiation. Furthermore, emphasizes epigenetic modifications metabolic reprogramming creating trained immunity, phenomenon whereby acquire long-term characteristics sustain states. Finally, we explore therapeutic strategies aimed at targeting mitigate inflammation its sequelae. Novel interventions modulate hematopoiesis restore hold promise treatment diseases. By interrupting vicious cycle dysregulation, therapies may offer new avenues reducing cardiovascular risk improving patient outcomes.

Язык: Английский

Процитировано

0
Emerging Mechanisms and Biomarkers Associated with T-Cells and B-Cells in Autoimmune Disorders DOI
Azhagu Madhavan Sivalingam

Clinical Reviews in Allergy & Immunology, Год журнала: 2025, Номер 68(1)

Опубликована: Фев. 11, 2025

Язык: Английский

Процитировано

0
Neuroimmune circuits in the plaque and bone marrow regulate atherosclerosis DOI Creative Commons
Teresa Gerhardt, Pacific Huynh, Cameron S. McAlpine

и другие.

Cardiovascular Research, Год журнала: 2024, Номер unknown

Опубликована: Июль 31, 2024

Atherosclerosis remains the leading cause of death globally. Although its focal pathology is atheroma that develops in arterial walls, atherosclerosis a systemic disease involving contributions by many organs and tissues. It now established immune system causally contributes to all phases atherosclerosis. Recent emerging evidence positions nervous as key modulator inflammatory processes underly This neuro-immune crosstalk, we are learning, bidirectional, regulated afferent signaling becoming increasingly recognized Here, summarize data concepts link systems focusing on two important sites, vessel bone marrow.

Язык: Английский

Процитировано

2
Acute exercise boosts NAD+ metabolism of human peripheral blood mononuclear cells DOI Creative Commons
David Walzik, Niklas Joisten, Alexander Schenk

и другие.

Brain Behavior and Immunity, Год журнала: 2024, Номер 123, С. 1011 - 1023

Опубликована: Ноя. 3, 2024

Процитировано

2