Abstract
Background
Cancer-therapy
related
cardiac
dysfunction
(CTRCD)
remains
a
significant
cause
of
morbidity
and
mortality
in
cancer
survivors.
In
this
study,
we
aimed
to
identify
differential
plasma
proteins
metabolites
associated
with
left
ventricular
(LVD)
patients.
Methods
We
analyzed
data
from
50
patients
referred
the
Cleveland
Clinic
Cardio-Oncology
Center
for
echocardiograph
assessment,
integrating
electronic
health
records,
proteomic,
metabolomic
profiles.
LVD
was
defined
as
an
ejection
fraction
≤
55%
based
on
echocardiographic
evaluation.
Classification-based
machine
learning
models
were
used
predict
using
input
features.
Results
identified
13
(
P
<
0.05)
14
LVD.
Key
included
markers
inflammation
(ST2,
TNFRSF14,
OPN,
AXL)
chemotaxis
(RARRES2,
MMP-2,
MEPE,
OPN).
Notably,
sex-specific
associations
observed,
such
uridine
=
0.003)
males.
Furthermore,
features
significantly
1-Methyl-4-imidazoleacetic
acid
0.015),
COL1A1
0.009),
MMP-2
0.016),
pointing
metabolic
shifts
heightened
Conclusion
Our
findings
suggest
that
circulating
may
non-invasively
detect
clinical
molecular
differences
LVD,
providing
insights
into
underlying
disease
pathways
potential
therapeutic
targets.
Cellular & Molecular Biology Letters,
Год журнала:
2025,
Номер
30(1)
Опубликована: Янв. 6, 2025
Abstract
Hypoxia-inducible
factors
(HIFs)
are
essential
transcription
that
orchestrate
cellular
responses
to
oxygen
deprivation.
HIF-1α,
as
an
unstable
subunit
of
HIF-1,
is
usually
hydroxylated
by
prolyl
hydroxylase
domain
enzymes
under
normoxic
conditions,
leading
ubiquitination
and
proteasomal
degradation,
thereby
keeping
low
levels.
Instead
hypoxia,
sometimes
even
in
normoxia,
HIF-1α
translocates
into
the
nucleus,
dimerizes
with
HIF-1β
generate
then
activates
genes
involved
adaptive
such
angiogenesis,
metabolic
reprogramming,
survival,
which
presents
new
challenges
insights
its
role
processes.
Thus,
review
delves
mechanisms
HIF-1
maintains
stability
normoxia
including
but
not
limited
giving
transcriptional,
translational,
well
posttranslational
regulation
underscore
pivotal
adaptation
malignancy.
Moreover,
extensively
cancer
cardiovascular
diseases
potentially
serves
a
bridge
between
them.
An
overview
HIF-1-related
drugs
approved
or
clinical
trials
summarized,
highlighting
their
potential
capacity
for
targeting
toxicity
related
treatment.
The
provides
comprehensive
insight
HIF-1’s
regulatory
mechanism
paves
way
future
research
therapeutic
development.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(14), С. 7530 - 7530
Опубликована: Июль 9, 2024
Aging
is
a
multifaceted
process
influenced
by
hereditary
factors,
lifestyle,
and
environmental
elements.
As
time
progresses,
the
human
body
experiences
degenerative
changes
in
major
functions.
The
external
internal
signs
of
aging
manifest
various
ways,
including
skin
dryness,
wrinkles,
musculoskeletal
disorders,
cardiovascular
diseases,
diabetes,
neurodegenerative
cancer.
Additionally,
cancer,
like
aging,
complex
disease
that
arises
from
accumulation
genetic
epigenetic
alterations.
Circadian
clock
dysregulation
has
recently
been
identified
as
an
important
risk
factor
for
cancer
development.
Natural
compounds
herbal
medicines
have
gained
significant
attention
their
potential
preventing
age-related
diseases
inhibiting
progression.
These
demonstrate
antioxidant,
anti-inflammatory,
anti-proliferative,
pro-apoptotic,
anti-metastatic,
anti-angiogenic
effects
well
circadian
regulation.
This
review
explores
cancers,
specific
natural
targeting
key
features
these
conditions.
Rapid
and
accurate
detection
plays
a
critical
role
in
improving
the
survival
prognosis
of
patients
with
cardiovascular
disease,
but
traditional
methods
are
far
from
ideal
for
those
suspected
conditions.
Metabolite
analysis
based
on
nanomatrix-assisted
laser
desorption/ionization
mass
spectrometry
(NMALDI-MS)
is
considered
to
be
promising
technique
disease
diagnosis.
However,
performance
core
nanomatrixes
has
limited
its
clinical
application.
In
this
study,
we
constructed
3D
flower-shaped
cages
controllable
structured
metal-organic
frameworks
iron
oxide
nanoparticles
low
thermal
conductivity
significant
photothermal
effects.
The
elongation
incident
light
path
through
multilayer
reflection
significantly
enhances
effective
absorption
area
nanomatrixes.
Concurrently,
alternating
layered
structure
confines
energy,
reducing
losses.
Moreover,
increases
affinity
sites,
expanding
coverage.
This
approach
effectively
ionization
desorption
efficiency
during
LDI
process.
We
applied
technology
analyze
serum
metabolomes
myocardial
infarction,
heart
failure,
failure
combined
achieving
cost-effective,
high-throughput,
highly
accurate,
user-friendly
diseases.
Subsequently,
deep
detected
fingerprints
via
artificial
intelligence
models
screens
potential
metabolic
biomarkers,
providing
new
paradigm
diagnosis
Bleeding Thrombosis and Vascular Biology,
Год журнала:
2025,
Номер
4(1)
Опубликована: Фев. 24, 2025
The
complex
relationship
between
cardiovascular
disease
(CVD)
and
cancer
has
raised
significant
research
interest,
supported
by
growing
evidence
that
these
leading
causes
of
morbidity
mortality
share
several
pathogenetic
aspects.
“common
soil“
hypothesis
postulates
CVD
emerge
from
the
same
piece
earth
as
distinct
trees,
but
with
intermingled
roots,
represented
modifiable
risk
factors
underlying
molecular
mechanisms.
integration
prevention
through
lifestyle
metabolic
health
improvements
represents
a
necessity,
for
modern
public
health.
This
dual-benefit
approach
potential
to
reshape
how
we
understand,
approach,
ultimately
reduce
burden
two
world's
most
impactful
group
diseases.
Summary
Introduction
Cancer
research
has
revolutionised
the
treatment,
quality
of
life
and
expectancy
people
living
with
cancer.
Systemic
anti‐cancer
treatments
have
expanded
to
involve
not
only
cytotoxic
drugs,
but
targeted
drugs
immunotherapy.
Although
highly
effective
in
many
patients,
these
can
cause
serious
sometimes
life‐threatening
adverse
reactions.
As
part
their
patients
cancer
will
be
offered
both
systemic
therapy
surgery,
undergo
recurrent
episodes
aims
cure,
palliation
or
prolongation
expectancy.
It
is
important
for
anaesthetists
understand
effects
on
patients.
Methods
An
electronic
literature
search
using
was
conducted
May
2024
peer‐reviewed
articles
English.
initial
terms
‘anaesthesia’
‘chemotherapy’
revealed
that
existing
review
tailored
towards
neoadjuvant
setting
prompted
this
include
complications
therapies,
emergency
care
intra‐operative
administration
reflect
evolving
field.
A
narrative
approach
taken
discuss
common
regimens
complications.
Results
The
encompasses
a
wide
range
sub‐topics
including
pharmacology;
physiology;
peri‐operative
medicine;
specialist
surgery;
events;
safety.
Data
from
multicentre
trials
form
basis
current
treatment
practice
were
prioritised
during
selection
process.
Smaller
studies,
case
series
reports
included
illustrate
rarer
clinically
significant
specific
therapies.
Conclusions
comprehensive
understanding
immunotherapies.
There
are
potential
toxicities
associated
treatments,
particularly
context
surgery
within
operating
theatre
environment.
