Haematometabolism rewiring in atherosclerotic cardiovascular disease
Nature Reviews Cardiology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 2, 2025
Язык: Английский
Microplastics and Nanoplastics Increase Major Adverse Cardiac Events in Patients with Myocardial Infarction
Journal of Hazardous Materials,
Год журнала:
2025,
Номер
489, С. 137624 - 137624
Опубликована: Фев. 19, 2025
Microplastics
and
nanoplastics
(MNPs)
have
implicated
in
cardiovascular
disease
preclinical
studies.
Our
objective
is
to
investigate
the
relationship
between
MNPs
coronary
arteries
major
adverse
cardiac
events
(MACE)
patients
with
myocardial
infarction
(MI).We
conducted
a
prospective
observational
study
involving
undergoing
angiography
for
MI.
Coronary
blood
samples
were
analyzed
presence
of
using
pyrolysis-gas
chromatography-mass
spectrometry.
A
total
142
enrolled,
110
completing
31.5-month
follow-up.
Among
them,
48
(43.6
%)
had
detectable
polystyrene,
79
(71.8
polyethylene,
105
(95.4
polyvinyl
chloride
(PVC),
68
(61.8
polyamide
66
their
blood.
PVC
concentration
was
higher
who
experienced
MACE.
Furthermore,
levels
positively
associated
proinflammatory
factors
(IL-1β,
IL-6,
IL-18,
TNF-α),
odds
MACE
(OR:
1.090,
95
%CI:
1.032-1.1523,
P
=
0.002).
Notably,
each
10-unit
increase
PVC,
there
1.374-fold
risk
(OR=2.374,
1.366-4.128,
Additionally,
we
collected
thrombus
from
an
additional
21
MI
patients,
finding
that
thrombi
correlated
inflammatory
markers
monocyte/macrophage
infiltration.
Язык: Английский
Lysosome Functions in Atherosclerosis: A Potential Therapeutic Target
Cells,
Год журнала:
2025,
Номер
14(3), С. 183 - 183
Опубликована: Янв. 24, 2025
Lysosomes
in
mammalian
cells
are
recognized
as
key
digestive
organelles,
containing
a
variety
of
hydrolytic
enzymes
that
enable
the
processing
both
endogenous
and
exogenous
substrates.
These
organelles
digest
various
macromolecules
recycle
them
through
autophagy–lysosomal
system.
Recent
research
has
expanded
our
understanding
lysosomes,
identifying
not
only
centers
degradation
but
also
crucial
regulators
nutrient
sensing,
immunity,
secretion,
other
vital
cellular
functions.
The
lysosomal
pathway
plays
significant
role
vascular
regulation
is
implicated
diseases
such
atherosclerosis.
During
atherosclerotic
plaque
formation,
macrophages
initially
engulf
large
quantities
lipoproteins,
triggering
pathogenic
responses
include
dysfunction,
foam
cell
subsequent
atherosclerosis
development.
Lysosomal
along
with
inefficient
apoptotic
accumulation
modified
low-density
negatively
impacts
lesion
progression.
studies
have
highlighted
dysfunction
contributes
critically
to
cell-
stage-specific
manner.
In
this
review,
we
discuss
mechanisms
biogenesis
its
regulatory
lesions.
Based
on
these
functions,
propose
targeting
lysosomes
could
offer
novel
therapeutic
approach
for
atherosclerosis,
shedding
light
connection
between
disease
progression
while
offering
new
insights
into
potential
anti-atherosclerotic
strategies.
Язык: Английский
Obesity alters cholesterol homeostasis in regulatory T cells of visceral adipose tissue
Nature Reviews Cardiology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 28, 2025
Язык: Английский
Copper Oxide Nanoparticles Disrupt Lysosomal Function and Promote Foam Cell Formation in RAW264.7 Macrophages
Toxicology,
Год журнала:
2025,
Номер
513, С. 154101 - 154101
Опубликована: Фев. 21, 2025
Язык: Английский
CKLF1 disrupts microglial efferocytosis following acute ischemic stroke by binding to phosphatidylserine
Cell Death and Differentiation,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 8, 2025
Язык: Английский
Obesity modulates NK-cell activity via LDL & DUSP1 signaling for Populations with Adverse Social Determinants
JCI Insight,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 24, 2024
African
American
(AA)
women
are
disproportionally
affected
by
obesity
and
hyperlipidemia,
particularly
in
the
setting
of
adverse
social
determinants
health
(aSDoH)
contributing
to
disparities.
Obesity,
aSDoH
appear
impair
Natural
Killer
cells
(NKs).
As
potential
common
underlying
mechanisms
largely
unknown,
we
sought
investigate
signaling
pathways
involved
NK
dysfunction
related
hyperlipidemia
AA
from
under-resourced
neighborhoods.
We
determined
freshly
isolated
NKs
that
measures
associated
with
a
shift
subsets
away
CD56dim/CD16+
cytotoxic
NKs.
Using
ex
vivo
data,
identified
LDL
as
marker
cell
function
an
population
Additionally,
LDL-treated
displayed
loss
function.
Comparative
unbiased
RNA
sequencing
analysis
revealed
DUSP1
factor.
Subsequently,
chemical
inhibition
overexpression
highlighted
its
significance
lysosome
biogenesis
mTOR/TFEB-related
fashion.
Our
data
demonstrate
pathway
which
may
relate
dysfunction,
making
important
target
for
further
investigation
Язык: Английский