Biomimetic peptide self-assembly for functional materials

Nature Reviews Chemistry, Год журнала: 2020, Номер 4(11), С. 615 - 634

Опубликована: Сен. 15, 2020

Язык: Английский

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Nucleation and Growth of Amino Acid and Peptide Supramolecular Polymers through Liquid–Liquid Phase Separation

Angewandte Chemie International Edition, Год журнала: 2019, Номер 58(50), С. 18116 - 18123

Опубликована: Окт. 16, 2019

The transition of peptides and proteins from the solution phase into fibrillar structures is a general phenomenon encountered in functional aberrant biology increasingly exploited soft materials science. However, fundamental molecular events underpinning early stages their assembly subsequent growth have remained challenging to elucidate. Here, we show that liquid-liquid separation solute-rich solute-poor phases step leading nucleation supramolecular nanofibrils building blocks, including even amphiphilic amino acids. liquid droplets act as sites, allowing formation thermodynamically favorable following Ostwald's rule. entropy driven while mediated by enthalpic interactions characterized structural reorganization. These findings shed light on how barrier toward solid can be lowered through kinetic mechanism which proceeds metastable phase.

Язык: Английский

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Supramolecular Photothermal Effects: A Promising Mechanism for Efficient Thermal Conversion

Angewandte Chemie International Edition, Год журнала: 2019, Номер 59(10), С. 3793 - 3801

Опубликована: Окт. 1, 2019

Abstract Supramolecular assemblies have been very successful in regulating the photothermal conversion efficiency of organic materials a simple and flexible way, compared with conventional molecular synthesis. In these assemblies, it is inherent physiochemical mechanism that determines conversion, rather than assembly strategy. This Minireview summarizes supramolecular effects, which refer to unique features chemistry for efficiency. Emphasis placed on mechanisms how self‐assembly affects performance. The effects various types light‐harvesting species are discussed detail. timely interpretation promising future design high efficiency, precision, multiple functionalities wide array applications.

Язык: Английский

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Prebiotic Peptides: Molecular Hubs in the Origin of Life

Chemical Reviews, Год журнала: 2020, Номер 120(11), С. 4707 - 4765

Опубликована: Фев. 26, 2020

The fundamental roles that peptides and proteins play in today's biology makes it almost indisputable were key players the origin of life. Insofar as is appropriate to extrapolate back from extant prebiotic world, one must acknowledge critical importance interconnected molecular networks, likely with components, would have played life's origin. In this review, we summarize chemical processes involving could contributed early evolution, an emphasis on interactions between other classes organic molecules. We first mechanisms by which amino acids similar building blocks been produced elaborated into proto-peptides. Next, non-covalent well nucleic acids, lipids, carbohydrates, metal ions, aromatic molecules are discussed relation possible such evolution structure function. Finally, describe research structural alternatives covalent adducts acids/peptides propose ample future breakthroughs origin-of-life chemistry will stem investigations systems synergistic different emerge.

Язык: Английский

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Multifunctional Antimicrobial Biometallohydrogels Based on Amino Acid Coordinated Self‐Assembly

Small, Год журнала: 2020, Номер 16(8)

Опубликована: Янв. 29, 2020

Abstract There is a real need for new antibiotics against self‐evolving bacteria. One option to use biofriendly broad‐spectrum and mechanically tunable antimicrobial hydrogels that can combat multidrug‐resistant microbes. Whilst appealing, there are currently limited options. Herein, biometallohydrogels based on the self‐assembly local mineralization of Ag + ‐coordinated Fmoc‐amino acids reported. Such have advantages localized delivery sustained release, reduced drug dosage toxicity yet improved bioavailability, prolonged effect, mechanical strength. Furthermore, they directly interact with cell walls membrane, resulting in detachment plasma membrane leakage cytoplasm. This leads death, triggering significant antibacterial effect both Gram‐negative ( Escherichia coli ) Gram‐positive Staphylococcus aureus bacteria cells mice. study paves way developing multifunctional integration platform simple biomolecules coordinated toward broad range biomedical applications.

Язык: Английский

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From Protein Building Blocks to Functional Materials

ACS Nano, Год журнала: 2021, Номер 15(4), С. 5819 - 5837

Опубликована: Март 24, 2021

Proteins are the fundamental building blocks for high-performance materials in nature. Such fulfill structural roles, as case of silk and collagen, can generate active structures including cytoskeleton. Attention is increasingly turning to this versatile class molecules synthesis next-generation green functional a range applications. Protein nanofibrils supramolecular unit from which many macroscopic protein formed. In Review, we focus on multiscale assembly such formed naturally occurring proteins into new architectures discuss how they form basis material systems ranging bulk gels, films, fibers, micro/nanogels, condensates, materials. We review current emerging approaches process assemble these manner different their natural evolutionarily selected role but allows generation tailored functionality, with microfluidic approaches. finally opportunities challenges materials, applications that be involved system consists fully natural, biocompatible, biodegradable feedstocks yet has potential performance versatility rivalling best synthetic polymers.

Язык: Английский

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Amino‐Acid‐Encoded Supramolecular Photothermal Nanomedicine for Enhanced Cancer Therapy

Advanced Materials, Год журнала: 2022, Номер 34(16)

Опубликована: Фев. 18, 2022

Photothermal nanomedicine based on self-assembly of biological components, with excellent biosafety and customized performance, is vital significance for precision cancer therapy. However, the programmable design photothermal remains extremely challenging due to vulnerability variability noncovalent interactions governing supramolecular self-assembly. Herein, it reported that amino acid encoding a facile potent means construct nanodrugs controlled therapeutic activities. It found amount type dominates assembled nanostructures, structural stability, energy-conversion pathway, mechanism resulting nanodrugs. Two optimized are endowed robust integrity against disassembly along high conversion efficiency, efficient cellular internalization, enhanced tumor accumulation, which result in more ablation. This work demonstrates offers an unprecedented opportunity construction remarkable photoactive nanomedicines toward diagnostics therapeutics.

Язык: Английский

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Functional supramolecular systems: design and applications

Russian Chemical Reviews, Год журнала: 2021, Номер 90(8), С. 895 - 1107

Опубликована: Апрель 20, 2021

The interest in functional supramolecular systems for the design of innovative materials and technologies, able to fundamentally change world, is growing at a high pace. huge array publications that appeared recent years global literature calls systematization structural trends inherent formation these revealed different molecular platforms practically useful properties they exhibit. attention concentrated on topics related are actively explored institutes universities Russia last 10–15 years, such as chemistry host–guest complexes, crystal engineering, self-assembly self-organization solutions interfaces, biomimetics machines devices. bibliography includes 1714 references.

Язык: Английский

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Biomimic Nanozymes with Tunable Peroxidase-like Activity Based on the Confinement Effect of Metal–Organic Frameworks (MOFs) for Biosensing

Analytical Chemistry, Год журнала: 2022, Номер 94(11), С. 4821 - 4830

Опубликована: Март 9, 2022

Biomimic nanozymes coassembled by peptides or proteins and small active molecules provide an effective strategy to design attractive nanozymes. Although some promising have been reported, rational regulation for higher catalytic activity of biomimic remains challenging. Hence, we proposed a novel nanozyme encapsulating the coassembly hemin/bovine serum albumin (BSA) in zeolite imidazolate frameworks (ZIF-8) achieve controllable tailoring peroxidase-like via confinement effect. The assembly Hemin@BSA was inspired structure horseradish peroxidase (HRP), which hemin served as cofactor surrounded BSA blocking pocket construct favorable hydrophobic space substrate enrichment. Benefiting from effect, ZIF-8 with porous intracavity identified ideal outer layer accelerate transport internal circulation catalysis, significantly enhancing its activity. Especially, precise encapsulation could also prevent it decomposition harsh environments rapid crystallization around form protective shell. Based on improved Hemin@BSA@ZIF-8, several applications were successfully performed sensitive detection including H2O2, glucose, bisphenol A (BPA). Satisfactory results highlight that using encapsulate offers very successful improve stability nanozymes, broadening potential application biocatalytic metal-organic (MOFs).

Язык: Английский

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Biomimetic Nanozymes Based on Coassembly of Amino Acid and Hemin for Catalytic Oxidation and Sensing of Biomolecules

Small, Год журнала: 2021, Номер 17(19)

Опубликована: Март 24, 2021

Nanoassemblies based on self-assembly of biological building blocks are promising in mimicking the nanostructures, properties, and functionalities natural enzymes. However, it remains a challenge to design biomimetic nanozymes with tunable nanostructures enhanced catalytic activities starting from simple biomolecules. Herein, construction nanoassemblies through coassembly an amphiphilic amino acid hemin is reported. The morphologies resulting readily controlled by tuning molar ratio between hemin, thus leading tailored peroxidase-mimicking nanoassemblies. Importantly, optimized exhibit remarkable efficiency that comparable counterpart when considering molecular mass along good robustness multiple cycles. effectively integrated as sensing system for detection glucose. Therefore, this work demonstrates advanced capabilities can be constructed minimalist may promote rational applications nanozymes.

Язык: Английский

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