Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(10)
Опубликована: Янв. 23, 2024
Synthetic
breakthroughs
diversify
the
molecules
and
polymers
available
to
chemists.
We
now
report
first
successful
synthesis
of
a
series
optically-pure
2,2'-tethered
binaphthyl-embedded
helical
ladder
based
on
quantitative
chemoselective
ladderization
by
modified
alkyne
benzannulations
using
4-alkoxy-2,6-dimethylphenylethynyl
group
as
source,
inaccessible
conventional
approach
lacking
2,6-dimethyl
substituents.
Due
defect-free
helix
formation,
circular
dichroism
signal
increased
more
than
6
times
previously
reported
value.
The
resulting
secondary
structure
can
be
fine-tuned
controlling
binaphthyl
dihedral
angle
in
repeating
unit
with
variations
2,2'-alkylenedioxy
tethering
groups
one
carbon
atom
at
time.
optimization
structures
led
strong
circularly
polarized
luminescence
high
fluorescence
quantum
yield
(28
%)
dissymmetry
factor
(2.6×10
Advanced Functional Materials,
Год журнала:
2021,
Номер
31(44)
Опубликована: Фев. 19, 2021
Abstract
Biodegradable,
hydrophobic,
and
injectable
liquid
polymers
are
capable
of
achieving
the
minimally
invasive,
sustained,
local
release
drugs.
These
hydrophobic
also
have
potential
in
area
regenerative
medicine
where
biomaterial
should
be
stable
for
a
certain
period
then
degrade
to
allow
growth
cells/tissues.
This
review
presents
exclusive
coverage
biocompatible
pasty
or
that
can
injected
without
use
any
solvent
drug
delivery,
tissue
augmentation,
application.
The
synthesis
methodologies
several
major
types
used
biomedical
fields
their
properties
with
foremost
criteria
serve
as
localized
delivery
is
described.
biodegradable
discussed
aliphatic
polyesters,
polycarbonates
polyanhydrides,
prepared
from:
lactic
acid,
glycolic
caprolactone,
diols
diacids,
hydroxy
fatty
acids,
triglycerides
such
castor
oil.
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
63(6)
Опубликована: Дек. 21, 2023
Helical
morphologies
are
widely
observed
in
nature,
however,
it
is
very
challenging
to
prepare
artificial
helical
polymers.
Especially,
precisely
understanding
the
structure
information
of
metal-free
covalent
inorganic
polymers
via
single-crystal
X-ray
diffraction
(SCXRD)
analysis
rarely
explored.
Here,
we
successfully
a
novel
polymer
({[Te(C
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(10)
Опубликована: Янв. 23, 2024
Synthetic
breakthroughs
diversify
the
molecules
and
polymers
available
to
chemists.
We
now
report
first
successful
synthesis
of
a
series
optically-pure
2,2'-tethered
binaphthyl-embedded
helical
ladder
based
on
quantitative
chemoselective
ladderization
by
modified
alkyne
benzannulations
using
4-alkoxy-2,6-dimethylphenylethynyl
group
as
source,
inaccessible
conventional
approach
lacking
2,6-dimethyl
substituents.
Due
defect-free
helix
formation,
circular
dichroism
signal
increased
more
than
6
times
previously
reported
value.
The
resulting
secondary
structure
can
be
fine-tuned
controlling
binaphthyl
dihedral
angle
in
repeating
unit
with
variations
2,2'-alkylenedioxy
tethering
groups
one
carbon
atom
at
time.
optimization
structures
led
strong
circularly
polarized
luminescence
high
fluorescence
quantum
yield
(28
%)
dissymmetry
factor
(2.6×10
