Nucleic Acids Research,
Год журнала:
2023,
Номер
51(12), С. 6264 - 6285
Опубликована: Май 16, 2023
Abstract
Photodynamic
therapy
(PDT)
ideally
relies
on
the
administration,
selective
accumulation
and
photoactivation
of
a
photosensitizer
(PS)
into
diseased
tissues.
In
this
context,
we
report
new
heavy-atom-free
fluorescent
G-quadruplex
(G4)
DNA-binding
PS,
named
DBI.
We
reveal
by
fluorescence
microscopy
that
DBI
preferentially
localizes
in
intraluminal
vesicles
(ILVs),
precursors
exosomes,
which
are
key
components
cancer
cell
proliferation.
Moreover,
purified
exosomal
DNA
was
recognized
G4-specific
antibody,
thus
highlighting
presence
such
G4-forming
sequences
vesicles.
Despite
absence
signal
from
nuclei,
light-irradiated
DBI-treated
cells
generated
reactive
oxygen
species
(ROS),
triggering
3-fold
increase
nuclear
G4
foci,
slowing
fork
progression
elevated
levels
both
base
damage,
8-oxoguanine,
double-stranded
breaks.
Consequently,
found
to
exert
significant
phototoxic
effects
(at
nanomolar
scale)
toward
lines
tumor
organoids.
Furthermore,
vivo
testing
reveals
induces
not
only
formation
damage
but
also
apoptosis
zebrafish,
specifically
area
where
had
accumulated.
Collectively,
approach
shows
promise
for
image-guided
PDT.
Chemical Society Reviews,
Год журнала:
2023,
Номер
52(18), С. 6447 - 6496
Опубликована: Янв. 1, 2023
This
review
highlights
the
use
of
nanoprobes
to
stratify
various
therapeutic
modalities
and
provides
an
outlook
on
challenges
future
directions
for
patient
stratification.
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
62(24)
Опубликована: Апрель 13, 2023
Abstract
There
is
growing
interest
in
the
development
of
chemiluminescence
(CL)
probes
for
phototheranostics
because
their
minimized
tissue
autofluorescence.
However,
due
to
a
lack
near‐infrared
(NIR)‐absorbing
chemiluminophores,
current
NIR
CL‐guided
phototherapy
are
based
on
nanoparticles
made
up
multiple
components.
We
report
bright
unimolecular
chemiluminophores
with
absorptions
and
emissions,
long
CL
half‐lives
ideal
photodynamic
efficiency.
One
luminophore
modified
into
an
activatable
probe,
DBP
OL
,
turn‐on
signal
activity
that
specific
cancer
biomarker.
The
highly
sensitive
allows
therapy
which
completely
inhibits
tumor
growth
lung
metastasis
mouse
models,
can
be
applied
noninvasive
monitoring
metastasis.
provide
molecular
guidelines
NIR‐absorbing
imaging‐guided
phototherapy.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(38)
Опубликована: Апрель 23, 2024
Abstract
Currently,
microbial
infections
have
posed
an
arduous
challenge
to
global
public
health,
whereas
the
rise
of
antibiotic
resistance
is
rendering
traditional
therapies
futile,
prompting
development
new
antimicrobial
technologies.
Photoactive
nanomaterials
thus
garnered
a
thriving
interest
for
disinfection
owing
their
superior
antibacterial
efficaciousness,
favorable
biosafety,
and
rapidness
spatiotemporal
precision
in
excreting
bactericidal
actions.
The
review
summarizes
recent
advances
emerging
trends
design,
nanoengineering,
bioapplications
photoactive
antimicrobials.
It
commences
by
elaborating
fundamental
theories
on
bacterial
resistance,
mechanisms
phototherapy.
Subsequently,
regulation
effectiveness
comprehensively
discussed,
centering
criteria
strategies
tuning
photoabsorption
spectra,
photothermal
conversion,
photocatalytic
efficiency,
alongside
tactics
enabling
synergistic
therapies.
This
followed
comparative
analyses
techniques
modalities
synthesizing
engineering
with
diverse
structures,
forms,
functionalities.
Thereafter,
state‐of‐the‐art
applications
phototherapies
across
various
medical
sectors
are
portrayed,
key
challenges
opportunities
finally
discussed
spur
future
innovations
translation.
envisaged
provide
useful
guidance
devising
developing
nanomaterials‐based
photoresponsive
antimicrobials
application‐specific
materials
properties
biological
functions.
Angewandte Chemie International Edition,
Год журнала:
2022,
Номер
61(28)
Опубликована: Апрель 21, 2022
Abstract
Photodynamic
therapy
(PDT)
is
a
non‐invasive
treatment
modality
against
range
of
cancers
and
nonmalignant
diseases,
however
one
must
be
aware
the
risk
causing
phototoxic
reactions
after
treatment.
We
herein
report
bioinspired
design
next‐generation
photosensitizers
(PSs)
that
not
only
effectively
produce
ROS
but
undergo
fast
metabolism
to
overcome
undesirable
side
effects.
constructed
series
β‐pyrrolic
ring‐opening
seco
‐chlorins,
termed
beidaphyrin
(
BP
),
beidapholactone
BPL
their
zinc(II)
derivatives
ZnBP
ZnBPL
featuring
intense
near‐infrared
absorption
effective
O
2
photosensitization.
Irradiation
led
non‐cytotoxic,
metabolizable
beidaphodiacetamide
ZnBPD
)
via
in
situ
generated
.−
1
,
as
revealed
by
mechanistic
studies
including
time‐resolved
absorption,
kinetics,
isotope
labeling.
Furthermore,
water‐soluble
showed
an
therapeutic
outcome,
metabolism,
negligible
reactions.
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
12(22)
Опубликована: Апрель 11, 2023
Owing
to
their
long
absorption
wavelengths,
high
molar
absorptivity,
and
tunable
photosensitivity,
phthalocyanines
have
been
widely
used
in
photodynamic
therapy
(PDT).
However,
still
face
the
drawbacks
of
poor
targeting,
"always-on"
photosensitizing
properties,
unsatisfactory
therapeutic
efficiency,
which
limit
wide
applications
biomedical
fields.
Thus,
new
design
strategies
such
as
modification
targeting
molecules,
formation
nanoparticles,
activating
photosensitizers
are
developed
improve
above
defects.
Notably,
recent
studies
shown
that
novel
not
only
fluorescence
imaging
PDT,
but
also
photoacoustic
imaging,
photothermal
sonodynamic
therapy,
therapy.
This
review
focuses
on
strategies,
biomedicine,
clinical
development
phthalocyanines,
providing
ideas
references
for
application
phthalocyanine,
so
promote
future
transformation
into
applications.
Abstract
Antimicrobial
resistance
(AMR)
is
a
growing
global
problem
with
more
than
1
million
deaths
due
to
AMR
infection
in
2019
alone.
New
and
innovative
therapeutics
are
required
overcome
this
challenge.
photodynamic
therapy
(aPDT)
rapidly
area
of
research
poised
provide
much
needed
help
the
fight
against
AMR.
aPDT
works
by
administering
photosensitizer
(PS)
that
activated
only
when
irradiated
light,
allowing
high
spatiotemporal
control
selectivity.
The
PS
typically
generates
reactive
oxygen
species
(ROS),
which
can
damage
variety
key
biological
targets,
potentially
circumventing
existing
mechanisms.
Metal
complexes
well
known
display
excellent
optoelectronic
properties,
recent
focus
has
begun
shift
towards
their
application
tackling
microbial
infections.
Herein,
we
review
last
five
years
progress
emerging
field
small‐molecule
metal
complex
PSs
for
aPDT.
