Cancer Letters,
Год журнала:
2024,
Номер
598, С. 217077 - 217077
Опубликована: Июнь 20, 2024
The
existence
of
microbiome
in
human
tumors
has
been
determined
widely,
but
evaluating
the
contribution
intratumoral
bacteria
and
fungi
to
tumor
immunity
prognosis
from
a
pan-cancer
perspective
remains
absent.
We
designed
an
improved
microbial
analysis
pipeline
reduce
interference
host
sequences,
complemented
with
integration
microbiota
at
species
level
clinical
indicators,
microenvironment,
across
cancer
types.
found
that
is
associated
immunophenotyping,
high-immunity
subtypes
showing
greater
bacterial
fungal
richness
compared
low-immunity
groups.
also
noted
combination
demonstrated
promising
prognostic
value
We,
thus,
present
Cancer
Microbiota
(TCMbio),
interactive
platform
provides
data,
comprehensive
module
for
33
types
cancers.
This
led
discovery
significance
microbes.
Gut
bacteria
are
related
to
immune
checkpoint
inhibitors
(ICIs).
However,
there
is
inconsistency
in
ICI-associated
species,
while
the
role
of
non-bacterial
microbes
immunotherapy
remains
elusive.
Here,
we
evaluated
association
trans-kingdom
with
ICIs
by
multi-cohort
multi-cancer
analyses.
Non-coding RNA Research,
Год журнала:
2023,
Номер
9(1), С. 236 - 252
Опубликована: Дек. 15, 2023
Gastrointestinal
cancers
are
a
huge
worldwide
health
concern,
which
includes
wide
variety
of
digestive
tract
cancers.
Circular
RNAs
(circRNAs),
kind
non-coding
RNA
(ncRNAs),
family
single-stranded,
covalently
closed
that
have
become
recognized
as
crucial
gene
expression
regulators,
having
an
impact
on
several
cellular
functions
in
cancer
biology.
The
gut
microbiome,
consists
different
bacteria,
actively
contributes
to
the
regulation
host
immunity,
inflammation,
and
metabolism.
CircRNAs
microbiome
interact
significantly
greatly
affect
growth
GI
cancer.
Several
studies
focus
complex
circRNAs
microbiota
cancers,
including
esophageal
cancer,
colorectal
gastric
hepatocellular
pancreatic
It
also
emphasizes
how
changed
circRNA
profiles
pathways
connected
malignancy
well
hallmarks
gastrointestinal
Furthermore,
been
recommended
biological
markers
for
therapeutic
targets
diagnostic
prognostic
purposes.
Targeting
treatment
is
being
continued
study.
Despite
significant
initiatives,
connection
between
emergence
remains
poorly
understood.
In
this
study,
we
will
go
over
most
recent
emphasize
key
roles
progression
options.
order
create
effective
therapies
plan
future
therapy,
it
important
comprehend
mechanisms
microbiota.
