Clinical and Experimental Medicine,
Год журнала:
2024,
Номер
24(1)
Опубликована: Июль 25, 2024
Abstract
Cancers
associated
with
pathogen
infections
are
gradually
becoming
important
threats
to
human
health
globally,
and
it
is
of
great
significance
study
the
mechanisms
carcinogenesis.
Current
mechanistic
studies
rely
on
animal
two-dimensional
(2D)
cell
culture
models,
but
traditional
methods
have
been
proven
insufficient
for
rapid
modeling
diseases
caused
by
new
pathogens.
Therefore,
research
focus
has
shifted
organoid
which
can
replicate
structural
genetic
characteristics
target
tissues
or
organs
in
vitro,
providing
platforms
pathogen-induced
oncogenic
mechanisms.
This
review
summarizes
application
technology
four
pathogen-associated
cancers:
gastric
cancer
linked
Helicobacter
pylori
,
liver
hepatitis
B
virus
C
virus,
colorectal
Escherichia
coli
cervical
related
papillomavirus.
also
proposes
several
limitations
optimize
models
advance
treatment
future.
Expert Review of Pharmacoeconomics & Outcomes Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 9, 2025
Introduction
Cervical
cancer
is
almost
entirely
preventable
by
vaccination
and
screening.
Population
based
screening
programs
are
effective
cost
effective,
but
millions
of
people
do
not
have
access
to
these
programs,
causing
immense
suffering.
The
WHO
Global
Strategy
for
the
elimination
cervical
as
a
public
health
problem
calls
countries
meet
ambitious
vaccination,
treatment
targets.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Ноя. 14, 2024
Abstract
In
the
last
decade,
messenger
ribonucleic
acid
(mRNA)-based
drugs
have
gained
great
interest
in
both
immunotherapy
and
non-immunogenic
applications.
This
surge
can
be
largely
attributed
to
demonstration
of
distinct
advantages
offered
by
various
mRNA
molecules,
alongside
rapid
advancements
nucleic
delivery
systems.
It
is
noteworthy
that
immunogenicity
presents
a
double-edged
sword.
context
immunotherapy,
extra
supplementation
adjuvant
generally
required
for
induction
robust
immune
responses.
Conversely,
non-immunotherapeutic
scenarios,
activation
unwanted
considering
host
tolerability
high
expression
demand
mRNA-encoded
functional
proteins.
Herein,
mainly
focused
on
linear
non-replicating
mRNA,
we
overview
preclinical
clinical
progress
prospects
medicines
encompassing
vaccines
other
therapeutics.
We
also
highlight
importance
focusing
host-specific
variations,
including
age,
gender,
pathological
condition,
concurrent
medication
individual
patient,
maximized
efficacy
safety
upon
administration.
Furthermore,
deliberate
potential
challenges
may
encounter
realm
disease
treatment,
current
endeavors
improvement,
as
well
application
future
advancements.
Overall,
this
review
aims
present
comprehensive
understanding
mRNA-based
therapies
while
illuminating
prospective
development
drugs.
Bioconjugate Chemistry,
Год журнала:
2024,
Номер
35(11), С. 1797 - 1804
Опубликована: Окт. 15, 2024
The
incidence
of
cervical
cancer
caused
by
human
papillomavirus
(HPV)
infection
has
increased
in
recent
years.
More
than
half
all
cases
are
due
to
HPV16
and
HPV18
infection,
so
testing
is
essential
prevent
cancer.
HPV
mainly
carried
out
hospitals,
but
it
subject
time
specialized
medical
facilities.
On
the
other
hand,
home
self-testing
using
simple
diagnostics
would
present
an
attractive
alternative
privacy
flexibility
with
regard
place,
provided
sufficient
sensitivity
specificity
can
be
achieved.
In
this
work,
a
dual
lateral
flow
assay
based
on
RPA-CRISPR-Cas12a/13a
(named
RC-LFA)
for
detection
was
described.
Taking
advantage
cleavage
Cas12a
Cas13a,
CRISPR-Cas12a/Cas13a
system
designed
detect
HPV18.
strip
two
test
lines
suit
CRISPR-Cas12a/Cas13
system.
RC-LFA
achieves
rapid
simultaneous
high
(10
copies/μL)
about
40
min
from
extraction
nucleic
acid
instrument-free
readout.
user-friendly
instrument-free,
making
promising
method
self-tests
at
home.
Vaccines,
Год журнала:
2024,
Номер
12(11), С. 1293 - 1293
Опубликована: Ноя. 19, 2024
Human
papillomavirus
(HPV)
is
a
widespread
viral
pathogen,
responsible
for
significant
burden
of
cervical
and
other
cancers
worldwide.
Over
the
past
decades,
development
adoption
prophylactic
HPV
vaccines
have
dramatically
reduced
incidence
HPV-related
diseases.
However,
despite
efficacy
these
vaccines,
global
immunization
efforts
still
face
several
obstacles,
including
low
vaccination
coverage
in
low-
middle-income
countries,
vaccine
hesitancy,
disparities
access
to
healthcare.
This
review
aims
provide
comprehensive
overview
current
state
their
mechanisms
action,
safety
profiles,
real-world
efficacy.
We
will
explore
impact
on
cancer
prevention,
examine
challenges
related
distribution
uptake,
assess
role
public
health
policies
improving
rates.
Additionally,
highlight
latest
advancements
therapeutic
ongoing
research
into
next-generation
potential
strategies
context
personalized
medicine.
By
examining
factors,
we
aim
insights
future
directions
its
health.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 13, 2025
Abstract
During
human
papillomavirus
(HPV)
entry,
the
virus
exploits
COPI-dependent
retrograde
transport
to
cross
trans-Golgi
network
and
Golgi
stacks
before
reaching
nucleus
cause
infection.
How
HPV
enters
after
exiting
is
unclear,
although
mitotic
nuclear
envelop
breakdown
(NEB)
appears
important.
Here
we
show
that
importin-7
(IPO7),
a
pore
import
receptor,
associates
with
promotes
Upon
IPO7
knockdown,
infection
inhibited
accumulates
in
but
does
not
enter
nucleus,
demonstrating
Golgi-to-nucleus
of
HPV.
We
further
reveal
C-terminus
capsid
protein
L2,
which
thought
contain
overlapping
localization
cell-penetrating
peptide
sequences,
binds
directly
step
requires
trafficking.
Together
these
data
identify
role
an
importin
infection,
raising
possibility
canonical
machinery
plays
unanticipated
NEB-dependent
entry.
Teaser
HPV,
cancer-causing
pathogen,
Golgi-associated
receptor
for
trafficking
promote
