Liquid Biopsy and Challenge of Assay Heterogeneity for Minimal Residual Disease Assessment in Colon Cancer Treatment

Genes, Год журнала: 2025, Номер 16(1), С. 71 - 71

Опубликована: Янв. 9, 2025

This review provides a comprehensive overview of the evolving role minimal residual disease (MRD) for patients with Colon Cancer (CC). Currently, standard care non-metastatic CC is adjuvant chemotherapy (ACT) all stage III and high-risk II following surgical intervention. Despite 5-20% improvement in long-term survival outcomes, this approach also results significant proportion receiving ACT without any therapeutic benefit being unnecessarily exposed to risks secondary side effects. underscores an unmet clinical need more precise stratification distinguish who necessitate from those can be treated surgery alone. By employing liquid biopsy, it possible discern MRD enabling categorization as MRD-positive or MRD-negative, potentially revolutionizing management ACT. aimed examine heterogeneity methodologies currently available detection, encompassing state-of-the-art technologies, their respective advantages, limitations, technological challenges multi-omic approaches that utilized enhance assay performance. Furthermore, discussion was held regarding trials employ focusing on assays used. These differences methodology, target selection, performance risk producing inconsistent may not solely reflect biological/clinical but consequence preferential use particular products studies conducted different countries. Standardization harmonization will crucial ensure revolution delivers reliable clinically actionable outcomes patients.

Язык: Английский

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Breaking up clusters of circulating tumour cells to halt cancer spread

Nature, Год журнала: 2025, Номер unknown

Опубликована: Янв. 28, 2025

Язык: Английский

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Liquid biopsy in head and neck cancer patients: blood, saliva or both?

Precision Clinical Medicine, Год журнала: 2025, Номер 8(1)

Опубликована: Янв. 7, 2025

Язык: Английский

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Recent advances in DNA nanotechnology for cancer detection and therapy: A review

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142136 - 142136

Опубликована: Март 1, 2025

Язык: Английский

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Translational Advances in Oncogene and Tumor-Suppressor Gene Research

Cancers, Год журнала: 2025, Номер 17(6), С. 1008 - 1008

Опубликована: Март 17, 2025

Cancer, characterized by the uncontrolled proliferation of cells, is one leading causes death globally, with approximately in five people developing disease their lifetime. While many driver genes were identified decades ago, and most cancers can be classified based on morphology progression, there still a significant gap knowledge about genetic aberrations nuclear DNA damage. The study two critical groups genes—tumor suppressors, which inhibit promote apoptosis, oncogenes, regulate survival—can help to understand genomic behind tumorigenesis, more personalized approaches diagnosis treatment. Aberration tumor undergo two-hit loss-of-function mutations, activated forms proto-oncogenes that experience one-hit gain-of-function are responsible for dysregulation key signaling pathways cell division, such as p53, Rb, Ras/Raf/ERK/MAPK, PI3K/AKT, Wnt/β-catenin. Modern breakthroughs genomics research, like next-generation sequencing, have provided efficient strategies mapping unique changes contribute heterogeneity. Novel therapeutic enabled medicine, helping address variability suppressors oncogenes. This comprehensive review examines molecular mechanisms tumor-suppressor they regulate, epigenetic modifications, heterogeneity, drug resistance drive carcinogenesis. Moreover, explores clinical application sequencing techniques, multiomics, diagnostic procedures, pharmacogenomics, treatment prevention options, discussing future directions emerging technologies.

Язык: Английский

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Study on the clinical application value of a new type of magnetic nanomicrospheres that can be used for circulating tumor cell sorting in lung cancer

Materials Today Chemistry, Год журнала: 2025, Номер 45, С. 102679 - 102679

Опубликована: Апрель 1, 2025

Язык: Английский

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