How COVID-19 shaped mental health: from infection to pandemic effects

Nature Medicine, Год журнала: 2022, Номер 28(10), С. 2027 - 2037

Опубликована: Окт. 1, 2022

Язык: Английский

---

The degree of frailty as a translational measure of health in aging

Nature Aging, Год журнала: 2021, Номер 1(8), С. 651 - 665

Опубликована: Авг. 12, 2021

Язык: Английский

---

The inter-relationship between delirium and dementia: the importance of delirium prevention

Nature Reviews Neurology, Год журнала: 2022, Номер 18(10), С. 579 - 596

Опубликована: Авг. 26, 2022

Язык: Английский

---

Diagnostic accuracy of the 4AT for delirium detection in older adults: systematic review and meta-analysis

Age and Ageing, Год журнала: 2020, Номер 50(3), С. 733 - 743

Опубликована: Окт. 1, 2020

Detection of delirium in hospitalised older adults is recommended national and international guidelines. The 4 'A's Test (4AT) a short (<2 minutes) instrument for detection that used internationally as standard tool clinical practice. We performed systematic review meta-analysis diagnostic test accuracy the 4AT detection.

Язык: Английский

---

Non-pharmacological interventions for preventing delirium in hospitalised non-ICU patients

Cochrane library, Год журнала: 2021, Номер 2021(7)

Опубликована: Июль 19, 2021

Язык: Английский

---

Predisposing and Precipitating Factors Associated With Delirium

JAMA Network Open, Год журнала: 2023, Номер 6(1), С. e2249950 - e2249950

Опубликована: Янв. 6, 2023

Despite discrete etiologies leading to delirium, it is treated as a common end point in hospital and clinical trials, delirium research may be hampered by the attempt treat all instances of similarly, leaving management an unmet need. An individualized approach based on unique patterns pathophysiology, reflected predisposing factors precipitants, necessary, but there exists no accepted method grouping into distinct etiologic subgroups.To conduct systematic review identify potential precipitating associated with adult patients agnostic setting.A literature search was performed PubMed, Embase, Web Science, PsycINFO from database inception December 2021 using Medical Subject Headings (MeSH) terms consciousness disorders, confusion, causality, disease susceptibility, constraints cohort or case-control studies. Two reviewers selected studies that met following criteria for inclusion: published English, prospective study, at least 50 participants, assessment person physician trained personnel reference standard, results including multivariable model independent delirium.A total 315 were included mean (SD) Newcastle-Ottawa Scale score 8.3 (0.8) out 9. Across 101 144 (50 006 [50.0%] male 49 766 [49.1%] female patients) represented (24 015 delirium), reported 33 112 delirium. There diversity substantial physiological heterogeneity.In this review, comprehensive list found across settings. These findings used inform more precise study delirium's heterogeneous pathophysiology treatment.

Язык: Английский

---

Evidence‐based strategies to reduce the incidence of postoperative delirium: a narrative review

Anaesthesia, Год журнала: 2022, Номер 77(S1), С. 92 - 101

Опубликована: Янв. 1, 2022

Summary Delirium is one of the most commonly occurring postoperative complications in older adults. It occurs due to vulnerability cerebral functioning pathophysiological stressors. Identification those at increased risk developing delirium early surgical pathway provides an opportunity for modification predisposing and precipitating factors effective shared decision‐making. No single prediction tool used widely settings. Multi‐component interventions prevent involve structured factor supported by geriatrician input; these are clinically efficacious cost effective. Barriers widespread implementation such complex exist, resulting ‘implementation gap’. There a lack evidence pharmacological prophylaxis prevention delirium. Current suggests that avoidance peri‐operative benzodiazepines, careful titration anaesthetic depth guided processed electroencephalogram monitoring treatment pain strategies minimise Addressing requires collaborative, whole approach, beginning with identification patients who risk. The research agenda should continue examine potential while also addressing how successful models can be translated from setting another, underpinned science methodology.

Язык: Английский

---

Dexmedetomidine vs other sedatives in critically ill mechanically ventilated adults: a systematic review and meta-analysis of randomized trials

Intensive Care Medicine, Год журнала: 2022, Номер 48(7), С. 811 - 840

Опубликована: Июнь 1, 2022

Язык: Английский

---

Update of the European Society of Anaesthesiology and Intensive Care Medicine evidence-based and consensus-based guideline on postoperative delirium in adult patients

European Journal of Anaesthesiology, Год журнала: 2023, Номер unknown

Опубликована: Авг. 21, 2023

Postoperative delirium (POD) remains a common, dangerous and resource-consuming adverse event but is often preventable. The whole peri-operative team can play key role in its management. This update to the 2017 ESAIC Guideline on prevention of POD evidence-based consensus-based considers literature between 01 April 2015, 28 February 2022. search terms broad were identical those used first version guideline published 2017. was defined accordance with DSM-5 criteria. had be measured validated screening tool, at least once per day for 3 days starting recovery room or postanaesthesia care unit surgery or, latest, postoperative 1. Recent confirmed pathogenic surgery-induced inflammation, this concept reinforces positive multicomponent strategies aimed reduce surgical stress response. Although some putative precipitating risk factors are not modifiable (length surgery, site), others (such as depth anaesthesia, appropriate analgesia haemodynamic stability) under control anaesthesiologists. Multicomponent preoperative, intra-operative preventive measures showed potential incidence duration POD, confirming pivotal comprehensive team-based approach improve patients’ clinical functional status.

Язык: Английский

---

Ultrathin, Soft, Bioresorbable Organic Electrochemical Transistors for Transient Spatiotemporal Mapping of Brain Activity

Advanced Science, Год журнала: 2023, Номер 10(14)

Опубликована: Фев. 24, 2023

Abstract A critical challenge lies in the development of next‐generation neural interface, mechanically tissue‐compatible fashion, that offer accurate, transient recording electrophysiological (EP) information and autonomous degradation after stable operation. Here, an ultrathin, lightweight, soft multichannel interface is presented based on organic‐electrochemical‐transistor‐(OECT)‐based network, with capabilities continuous high‐fidelity mapping signals biosafety active degrading performing functions. Such platform yields a high spatiotemporal resolution 1.42 ms 20 µm, signal‐to‐noise ratio up to ≈37 dB. The implantable OECT arrays can well establish functional interfaces, designed as fully biodegradable electronic platforms vivo. Demonstrated applications such implants include real‐time monitoring electrical activities from cortical surface rats under various conditions (e.g., narcosis, epileptic seizure, electric stimuli) electrocorticography 100 channels. This technology offers general applicability great potential utility treatment/diagnosis neurological disorders.

Язык: Английский

---