Journal of Hematology & Oncology,
Год журнала:
2019,
Номер
12(1)
Опубликована: Сен. 6, 2019
Tumor
neoantigen
is
the
truly
foreign
protein
and
entirely
absent
from
normal
human
organs/tissues.
It
could
be
specifically
recognized
by
neoantigen-specific
T
cell
receptors
(TCRs)
in
context
of
major
histocompatibility
complexes
(MHCs)
molecules.
Emerging
evidence
has
suggested
that
neoantigens
play
a
critical
role
tumor-specific
cell-mediated
antitumor
immune
response
successful
cancer
immunotherapies.
From
theoretical
perspective,
an
ideal
immunotherapy
target
because
they
are
distinguished
germline
as
non-self
host
system.
Neoantigen-based
therapeutic
personalized
vaccines
adoptive
transfer
have
shown
promising
preliminary
results.
Furthermore,
recent
studies
significant
escape,
immunoediting,
sensitivity
to
checkpoint
inhibitors.
In
this
review,
we
systematically
summarize
advances
understanding
identification
its
on
current
We
also
discuss
ongoing
development
strategies
based
future
clinical
applications.
Nucleic Acids Research,
Год журнала:
2020,
Номер
48(W1), С. W509 - W514
Опубликована: Май 17, 2020
Abstract
Tumor
progression
and
the
efficacy
of
immunotherapy
are
strongly
influenced
by
composition
abundance
immune
cells
in
tumor
microenvironment.
Due
to
limitations
direct
measurement
methods,
computational
algorithms
often
used
infer
cell
from
bulk
transcriptome
profiles.
These
estimated
infiltrate
populations
have
been
associated
with
genomic
transcriptomic
changes
tumors,
providing
insight
into
tumor–immune
interactions.
However,
such
investigations
on
large-scale
public
data
remain
challenging.
To
lower
barriers
for
analysis
complex
interactions,
we
significantly
improved
our
previous
web
platform
TIMER.
Instead
just
using
one
algorithm,
TIMER2.0
(http://timer.cistrome.org/)
provides
more
robust
estimation
infiltration
levels
The
Cancer
Genome
Atlas
(TCGA)
or
user-provided
profiles
six
state-of-the-art
algorithms.
four
modules
investigating
associations
between
infiltrates
genetic
clinical
features,
exploring
cancer-related
TCGA
cohorts.
Each
module
can
generate
a
functional
heatmap
table,
enabling
user
easily
identify
significant
multiple
cancer
types
simultaneously.
Overall,
server
comprehensive
visualization
functions
infiltrating
cells.
British Journal of Cancer,
Год журнала:
2020,
Номер
124(2), С. 359 - 367
Опубликована: Сен. 15, 2020
Abstract
The
functions
of,
and
interactions
between,
the
innate
adaptive
immune
systems
are
vital
for
anticancer
immunity.
Cytotoxic
T
cells
expressing
cell-surface
CD8
most
powerful
effectors
in
response
form
backbone
of
current
successful
cancer
immunotherapies.
Immune-checkpoint
inhibitors
designed
to
target
immune-inhibitory
receptors
that
function
regulate
response,
whereas
adoptive
cell-transfer
therapies
use
+
with
genetically
modified
receptors—chimaeric
antigen
receptors—to
specify
enhance
T-cell
functionality.
New
generations
cytotoxic
or
synthetic
being
developed
evaluated
clinical
trials.
Furthermore,
combinatory
regimens
might
optimise
treatment
effects
reduce
adverse
events.
This
review
summarises
advances
research
on
prominent
immunotherapy,
cells,
discusses
possible
implications
future
treatment.
Cell Death and Disease,
Год журнала:
2020,
Номер
11(11)
Опубликована: Ноя. 26, 2020
Abstract
Chemotherapy,
radiation
therapy,
as
well
targeted
anticancer
agents
can
induce
clinically
relevant
tumor-targeting
immune
responses,
which
critically
rely
on
the
antigenicity
of
malignant
cells
and
their
capacity
to
generate
adjuvant
signals.
In
particular,
immunogenic
cell
death
(ICD)
is
accompanied
by
exposure
release
numerous
damage-associated
molecular
patterns
(DAMPs),
altogether
confer
a
robust
adjuvanticity
dying
cancer
cells,
they
favor
recruitment
activation
antigen-presenting
cells.
ICD-associated
DAMPs
include
surface-exposed
calreticulin
(CALR)
secreted
ATP,
annexin
A1
(ANXA1),
type
I
interferon,
high-mobility
group
box
1
(HMGB1).
Additional
hallmarks
ICD
encompass
phosphorylation
eukaryotic
translation
initiation
factor
2
subunit-α
(EIF2S1,
better
known
eIF2α),
autophagy,
global
arrest
in
transcription
translation.
Here,
we
outline
methodological
approaches
for
measuring
markers
vitro
ex
vivo
discovery
next-generation
antineoplastic
agents,
development
personalized
regimens,
identification
optimal
therapeutic
combinations
clinical
management
cancer.
Signal Transduction and Targeted Therapy,
Год журнала:
2022,
Номер
7(1)
Опубликована: Июнь 20, 2022
Abstract
In
recent
years,
immunotherapy
represented
by
immune
checkpoint
inhibitors
(ICIs)
has
led
to
unprecedented
breakthroughs
in
cancer
treatment.
However,
the
fact
that
many
tumors
respond
poorly
or
even
not
ICIs,
partly
caused
absence
of
tumor-infiltrating
lymphocytes
(TILs),
significantly
limits
application
ICIs.
Converting
these
“cold”
into
“hot”
may
ICIs
is
an
unsolved
question
immunotherapy.
Since
it
a
general
characteristic
cancers
resist
apoptosis,
induction
non-apoptotic
regulated
cell
death
(RCD)
emerging
as
new
treatment
strategy.
Recently,
several
studies
have
revealed
interaction
between
RCD
and
antitumor
immunity.
Specifically,
autophagy,
ferroptosis,
pyroptosis,
necroptosis
exhibit
synergistic
responses
while
possibly
exerting
inhibitory
effects
on
responses.
Thus,
targeted
therapies
(inducers
inhibitors)
against
combination
with
exert
potent
activity,
resistant
This
review
summarizes
multilevel
relationship
immunity
RCD,
including
necroptosis,
potential
targeting
improve
efficacy
malignancy.
