Ageing Research Reviews,
Год журнала:
2023,
Номер
86, С. 101878 - 101878
Опубликована: Фев. 3, 2023
Neurodegenerative
diseases
are
the
most
common
causes
of
disability
worldwide.
Given
their
high
prevalence,
devastating
symptoms,
and
lack
definitive
diagnostic
tests,
there
is
an
urgent
need
to
identify
potential
biomarkers
new
therapeutic
targets.
Long
non-coding
RNAs
(lncRNAs)
have
recently
emerged
as
powerful
regulatory
molecules
in
neurodegenerative
diseases.
Among
them,
lncRNA
nuclear
paraspeckle
assembly
transcript
1
(NEAT1)
has
been
reported
be
upregulated
Alzheimer's
disease
(AD),
Parkinson's
(PD),
Huntington's
(HD),
amyotrophic
lateral
sclerosis
(ALS).
However,
whether
this
part
a
protective
or
harmful
mechanism
still
unclear.
This
review
summarizes
our
current
knowledge
role
NEAT1
its
association
with
characteristic
aggregation
misfolded
proteins:
amyloid-β
tau
AD,
α-synuclein
PD,
mutant
huntingtin
HD,
TAR
DNA-binding
protein-43
fused
sarcoma/translocated
liposarcoma
ALS.
The
aim
stimulate
further
research
on
more
precise
effective
treatments
for
Signal Transduction and Targeted Therapy,
Год журнала:
2022,
Номер
7(1)
Опубликована: Май 21, 2022
Abstract
The
therapeutic
use
of
messenger
RNA
(mRNA)
has
fueled
great
hope
to
combat
a
wide
range
incurable
diseases.
Recent
rapid
advances
in
biotechnology
and
molecular
medicine
have
enabled
the
production
almost
any
functional
protein/peptide
human
body
by
introducing
mRNA
as
vaccine
or
agent.
This
represents
rising
precision
field
with
promise
for
preventing
treating
many
intractable
genetic
In
addition,
vitro
transcribed
achieved
programmed
production,
which
is
more
effective,
faster
design
well
flexible
cost-effective
than
conventional
approaches
that
may
offer.
Based
on
these
extraordinary
advantages,
vaccines
characteristics
swiftest
response
large-scale
outbreaks
infectious
diseases,
such
currently
devastating
pandemic
COVID-19.
It
always
been
scientists’
desire
improve
stability,
immunogenicity,
translation
efficiency,
delivery
system
achieve
efficient
safe
mRNA.
Excitingly,
scientific
dreams
gradually
realized
rapid,
amazing
achievements
biology,
technology,
vaccinology,
nanotechnology.
this
review,
we
comprehensively
describe
mRNA-based
therapeutics,
including
their
principles,
manufacture,
application,
effects,
shortcomings.
We
also
highlight
importance
optimization
systems
successful
therapeutics
discuss
key
challenges
opportunities
developing
tools
into
powerful
versatile
genetic,
infectious,
cancer,
other
refractory
Cell Death and Disease,
Год журнала:
2022,
Номер
13(7)
Опубликована: Июль 23, 2022
Abstract
The
growing
understanding
of
RNA
functions
and
their
crucial
roles
in
diseases
promotes
the
application
various
RNAs
to
selectively
function
on
hitherto
“undruggable”
proteins,
transcripts
genes,
thus
potentially
broadening
therapeutic
targets.
Several
RNA-based
medications
have
been
approved
for
clinical
use,
while
others
are
still
under
investigation
or
preclinical
trials.
Various
techniques
explored
promote
intracellular
trafficking
metabolic
stability,
despite
significant
challenges
developing
therapeutics.
In
this
review,
mechanisms
action,
challenges,
solutions,
therapeutics
comprehensively
summarized.
Signal Transduction and Targeted Therapy,
Год журнала:
2022,
Номер
7(1)
Опубликована: Апрель 13, 2022
Abstract
It
is
now
well
known
that
non-coding
RNAs
(ncRNAs),
rather
than
protein-coding
transcripts,
are
the
preponderant
RNA
transcripts.
NcRNAs,
particularly
microRNAs
(miRNAs),
long
(lncRNAs),
and
circular
(circRNAs),
widely
appreciated
as
pervasive
regulators
of
multiple
cancer
hallmarks
such
proliferation,
apoptosis,
invasion,
metastasis,
genomic
instability.
Despite
recent
discoveries
in
therapy,
resistance
to
chemotherapy,
radiotherapy,
targeted
immunotherapy
continue
be
a
major
setback.
Recent
studies
have
shown
ncRNAs
also
play
role
different
therapies
by
rewiring
essential
signaling
pathways.
In
this
review,
we
present
intricate
mechanisms
through
which
dysregulated
control
four
types
therapies.
We
will
focus
on
current
clinical
implications
biomarkers
predict
treatment
response
(intrinsic
resistance)
detect
therapy
after
start
(acquired
resistance).
Furthermore,
potential
targeting
ncRNA
overcome
resistance,
discuss
challenges
ncRNA-targeted
therapy—especially
development
delivery
systems.
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Март 15, 2023
Exosome
is
a
subgroup
of
extracellular
vesicles,
which
has
been
serving
as
an
efficient
therapeutic
tool
for
various
diseases.
Engineered
exosomes
are
the
sort
modified
with
surface
decoration
and
internal
molecules.
After
appropriate
modification,
engineered
able
to
deliver
antitumor
drugs
tumor
sites
efficiently
precisely
fewer
treatment-related
adverse
effects.
However,
there
still
exist
many
challenges
clinical
translation
exosomes.
For
instance,
what
sources
modification
strategies
could
endow
most
activity
poorly
understood.
Additionally,
how
choose
appropriately
in
different
therapies
another
unresolved
problem.
In
this
review,
we
summarized
characteristics
exosomes,
especially
spatial
temporal
properties.
concluded
recent
advances
cancer
fields,
including
sources,
isolation
technologies,
strategies,
labeling
imaging
methods
Furthermore,
applications
were
summarized,
such
photodynamic
therapy,
gene
immunotherapy.
Consequently,
above
provides
researchers
community
latest
ideas
on
exosome
new
direction
drug
development,
prospective
accelerate
cancer-targeted
therapy.
Journal of Nanobiotechnology,
Год журнала:
2022,
Номер
20(1)
Опубликована: Июнь 14, 2022
Abstract
Cancer
is
a
leading
public
health
problem
worldwide.
Its
treatment
remains
daunting
challenge,
although
significant
progress
has
been
made
in
existing
treatments
recent
years.
A
large
concern
the
poor
therapeutic
effect
due
to
lack
of
specificity
and
low
bioavailability.
Gene
therapy
recently
emerged
as
powerful
tool
for
cancer
therapy.
However,
delivery
methods
limit
its
effects.
Exosomes,
subset
extracellular
vesicles
secreted
by
most
cells,
have
characteristics
good
biocompatibility,
toxicity
immunogenicity,
great
designability.
In
past
decades,
carriers
diagnostic
markers,
they
caught
extensive
attention.
This
review
introduced
exosomes,
focused
on
their
applications
DNA,
messenger
RNA
(mRNA),
microRNA
(miRNA),
small
interfering
(siRNA),
circular
(circRNA)
other
nucleic
acids.
Meanwhile,
application
exosome-based
clinical
trials
were
presented
discussed.
Through
systematic
summarization
analysis,
advances
current
challenges
exosome-mediated
acid
are
introduced,
which
will
provide
theoretical
basis
development
drugs.
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