Ageing Research Reviews,
Год журнала:
2023,
Номер
86, С. 101878 - 101878
Опубликована: Фев. 3, 2023
Neurodegenerative
diseases
are
the
most
common
causes
of
disability
worldwide.
Given
their
high
prevalence,
devastating
symptoms,
and
lack
definitive
diagnostic
tests,
there
is
an
urgent
need
to
identify
potential
biomarkers
new
therapeutic
targets.
Long
non-coding
RNAs
(lncRNAs)
have
recently
emerged
as
powerful
regulatory
molecules
in
neurodegenerative
diseases.
Among
them,
lncRNA
nuclear
paraspeckle
assembly
transcript
1
(NEAT1)
has
been
reported
be
upregulated
Alzheimer's
disease
(AD),
Parkinson's
(PD),
Huntington's
(HD),
amyotrophic
lateral
sclerosis
(ALS).
However,
whether
this
part
a
protective
or
harmful
mechanism
still
unclear.
This
review
summarizes
our
current
knowledge
role
NEAT1
its
association
with
characteristic
aggregation
misfolded
proteins:
amyloid-β
tau
AD,
α-synuclein
PD,
mutant
huntingtin
HD,
TAR
DNA-binding
protein-43
fused
sarcoma/translocated
liposarcoma
ALS.
The
aim
stimulate
further
research
on
more
precise
effective
treatments
for
Acta Pharmaceutica Sinica B,
Год журнала:
2022,
Номер
13(3), С. 916 - 941
Опубликована: Окт. 27, 2022
RNAs
are
involved
in
the
crucial
processes
of
disease
progression
and
have
emerged
as
powerful
therapeutic
targets
diagnostic
biomarkers.
However,
efficient
delivery
RNA
to
targeted
location
precise
detection
markers
remains
challenging.
Recently,
more
attention
has
been
paid
applying
nucleic
acid
nanoassemblies
diagnosing
treating.
Due
flexibility
deformability
acids,
could
be
fabricated
with
different
shapes
structures.
With
hybridization,
nanoassemblies,
including
DNA
nanostructures,
can
applied
enhance
therapeutics
diagnosis.
This
review
briefly
introduces
construction
properties
their
applications
for
therapy
diagnosis
makes
further
prospects
development.
Ageing Research Reviews,
Год журнала:
2023,
Номер
86, С. 101878 - 101878
Опубликована: Фев. 3, 2023
Neurodegenerative
diseases
are
the
most
common
causes
of
disability
worldwide.
Given
their
high
prevalence,
devastating
symptoms,
and
lack
definitive
diagnostic
tests,
there
is
an
urgent
need
to
identify
potential
biomarkers
new
therapeutic
targets.
Long
non-coding
RNAs
(lncRNAs)
have
recently
emerged
as
powerful
regulatory
molecules
in
neurodegenerative
diseases.
Among
them,
lncRNA
nuclear
paraspeckle
assembly
transcript
1
(NEAT1)
has
been
reported
be
upregulated
Alzheimer's
disease
(AD),
Parkinson's
(PD),
Huntington's
(HD),
amyotrophic
lateral
sclerosis
(ALS).
However,
whether
this
part
a
protective
or
harmful
mechanism
still
unclear.
This
review
summarizes
our
current
knowledge
role
NEAT1
its
association
with
characteristic
aggregation
misfolded
proteins:
amyloid-β
tau
AD,
α-synuclein
PD,
mutant
huntingtin
HD,
TAR
DNA-binding
protein-43
fused
sarcoma/translocated
liposarcoma
ALS.
The
aim
stimulate
further
research
on
more
precise
effective
treatments
for
