JEADV Clinical Practice,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 1, 2024
Abstract
Interleukins
are
central
in
the
modulation
of
immune
responses.
This
narrative
review
aims
to
summarize
growing
evidence
on
their
significance
as
key
drivers
numerous
cutaneous
diseases
with
a
special
focus
some
more
prevalent
chronic
inflammatory
dermatologic
such
psoriasis,
atopic
dermatitis,
allergic
contact
urticaria,
and
hidradenitis
suppurativa.
Additionally,
we
discuss
relevance
recent
developments
targeted
therapies
that
have
significantly
transformed
management
these
skin
conditions.
To
this
end,
conducted
comprehensive
search
through
Cochrane
Library
Database
Systematic
Reviews
MEDLINE
engine,
summarized
available
clinical
considering
up
466
records
including
meta‐analyses,
systematic
reviews,
reviews
trials.
Ultimately,
intents
foster
both
dermatologist
non‐dermatologist
physicians'
understanding
immunology
behind
manifestations
most
common
engage
novel
therapeutic
approaches
by
providing
accessible
insights
into
implications
interleukin
pathways
dysregulation.
Allergy,
Год журнала:
2024,
Номер
79(6), С. 1501 - 1515
Опубликована: Янв. 8, 2024
Atopic
dermatitis
(AD)
represents
the
most
common
skin
disease
characterized
by
heterogeneous
endophenotypes
and
a
high
burden.
In
Europe,
six
new
systemic
therapies
for
AD
have
been
approved:
biologics
dupilumab
(anti-interleukin-4
receptor
(IL-4R)
α
in
2017),
tralokinumab
(anti-IL-13
2021),
lebrikizumab
2023),
oral
janus
kinase
(JAK)
inhibitors
(JAKi)
targeting
JAK1/2
(baricitinib
2020
EU)
or
JAK1
(upadacitinib
2021
abrocitinib
2022).
Herein,
we
give
an
update
on
approvals,
long-term
safety,
efficacy.
Upadacitinib
highest
short-term
efficacy
among
approved
therapies.
responders,
catch
up
regarding
incremental
clinical
benefit
within
continuous
use.
Recently,
European
Medicines
Agency
has
released
recommendations
use
of
JAKi
patients
at
risk
(cardiovascular
thromboembolic
diseases,
malignancies,
(former)
smoking,
age
≥65
years).
Furthermore,
overview
emerging
currently
Phase
III
trials.
Among
topical
therapies,
tapinarof
(aryl
hydrocarbon
receptor),
ruxolitinib
(JAK1/2i),
delgocitinib
(pan-JAKi),
asivatrep
(anti-transient
potential
vanilloid),
phosphodiesterase-4-inhibitors
(roflumilast,
difamilast)
are
discussed.
current
data
cord-blood-derived
mesenchymal
stem
cells,
CM310
(anti
IL-4Rα),
nemolizumab
(anti-IL-31RA),
anti-OX40/OX40L-antibodies,
neurokinin-receptor-1-antagonists,
difelikefalin
(κ-opioid-R)
reported.
Ecotoxicology and Environmental Safety,
Год журнала:
2024,
Номер
278, С. 116429 - 116429
Опубликована: Май 7, 2024
Air
pollutants
deteriorate
the
survival
environment
and
endanger
human
health
around
world.
A
large
number
of
studies
have
confirmed
that
air
pollution
jeopardizes
multiple
organs,
such
as
cardiovascular,
respiratory,
central
nervous
systems.
Skin
is
largest
organ
first
barrier
protects
us
from
outside
particulate
matter
(PM),
polycyclic
aromatic
hydrocarbons
(PAHs),
volatile
organic
compounds
(VOCs)
will
affect
structure
function
skin
bring
about
development
inflammatory
diseases
(atopic
dermatitis
(AD),
psoriasis),
accessory
(acne,
alopecia),
auto-immune
(cutaneous
lupus
erythematosus(CLE)
scleroderma),
even
tumors
(melanoma,
basal
cell
carcinoma
(BCC),
squamous-cell
(SCC)).
Oxidative
stress,
damage,
microbiome
dysbiosis,
inflammation
are
pathogenesis
stimulation.
In
this
review,
we
summarize
current
evidence
on
effects
possible
mechanisms
to
provide
strategies
for
future
research.
ACS Nano,
Год журнала:
2024,
Номер
18(33), С. 22055 - 22070
Опубликована: Авг. 8, 2024
The
selective
elimination
of
cytotoxic
ROS
while
retaining
essential
ones
is
pivotal
in
the
management
chronic
inflammation.
Co-occurring
bacterial
infection
further
complicates
conditions,
necessitating
precision
and
an
efficacious
treatment
strategy.
Herein,
dynamic
nanomodulators
are
rationally
constructed
through
regulating
surface
states
herbal
carbon
dots
(CDs)
for
on-demand
inflammation
or
elimination.
phenolic
OH
containing
CDs
derived
from
honeysuckle
(HOCD)
dandelion
(DACD)
demonstrated
appropriate
redox
potentials,
ensuring
their
ability
to
scavenge
such
as
·OH
ONOO–,
invalidity
toward
O2·–,
H2O2,
NO.
This
enables
efficient
without
affecting
signal
pathways.
C–N/C═N
taxus
leaves
(TACD)
DACD
renders
them
with
suitable
band
structures,
facilitating
absorption
red
region
generation
O2·–
upon
light
irradiation
sterilization.
Specifically,
facilely
prepared
demonstrates
fascinating
modulating
ability,
making
it
highly
addressing
concurrent
infection,
diabetic
wound
infection.
regulation
strategy
facilitates
realization
precise
minimal
side
effects,
holding
immense
potential
clinical
practice.
Clinical and Translational Science,
Год журнала:
2024,
Номер
17(8)
Опубликована: Июль 30, 2024
Abstract
Allergic
disease
prevalence
has
increased
globally
with
the
subset
of
type
2
inflammatory
diseases
playing
a
substantial
role.
Type
may
differ
in
clinical
presentation,
but
they
exhibit
shared
pathophysiology
that
is
targeted
by
unique
pharmacology
dupilumab.
Dupilumab
binds
to
interleukin
(IL)‐4
receptor
alpha
subunit
(IL‐4Rα)
blocks
IL‐4
and
IL‐13
signaling,
two
key
drivers
inflammation.
Herein,
we
review
mechanism
action
dupilumab,
evidence
led
regulatory
approvals
dupilumab
for
treatment
numerous
diseases:
atopic
dermatitis,
asthma,
chronic
rhinosinusitis
nasal
polyposis,
eosinophilic
esophagitis,
prurigo
nodularis.
EBioMedicine,
Год журнала:
2024,
Номер
103, С. 105121 - 105121
Опубликована: Апрель 13, 2024
Atopic
dermatitis
(AD)
is
the
most
common
form
of
chronic
skin
inflammation
with
diverse
clinical
variants.
Historically,
various
AD
phenotypes
have
been
grouped
together
without
considering
their
heterogeneity.
This
approach
has
resulted
in
a
lack
phenotype-
and
endotype-adapted
therapeutic
strategies.
Comprehensive
insights
into
pathogenesis
enabled
precise
medicinal
for
AD.
These
efforts
aimed
to
redefine
endophenotype
develop
biomarkers
purposes.
Among
these
endeavours,
are
underway
elucidate
mechanisms
(and
related
biomarkers)
that
lead
emergence
progression
atopic
diseases
originating
from
(e.g.,
march).
review
focuses
on
calls
definition
endophenotypes.
While
awaiting
scientific
validation,
ensure
predicting
disease
onset
trajectory
tailoring
strategies
future.
Allergy,
Год журнала:
2024,
Номер
79(9), С. 2396 - 2413
Опубликована: Июль 24, 2024
Chronic
spontaneous
urticaria
(CSU)
is
a
debilitating,
inflammatory
skin
condition
characterized
by
infiltrating
immune
cells.
Available
treatments
are
limited
to
improving
the
signs
and
symptoms.
There
an
unmet
need
develop
therapies
that
target
disease-driving
pathways
upstream
of
mast
cell
activation
inhibit
or
delay
progression
CSU
associated
comorbidities.
Here,
we
aim
define
disease
modification
due
treatment
intervention
criteria
disease-modifying
(DMTs)
must
meet
in
CSU.
We
have
defined
as
favorable
treatment-induced
change
underlying
pathophysiology
and,
therefore,
course,
which
clinically
beneficial
enduring.
A
DMT
fulfil
following
criteria:
(1)
prevents
delays
CSU,
(2)
induces
long-term,
therapy-free
clinical
remission,
sustained
absence
symptoms
without
for
treatment,
(3)
affects
mechanism
demonstrated
effect
on
signals
and/or
biomarker.
DMTs
should
slow
progression,
achieve
long-lasting
mechanisms,
reduce
cell-activating
IgE
autoantibodies,
cytokine
profile
polarization,
normalize
gut
microbiome
barrier.
Treating
at
system
level
could
provide
valuable
alternatives
pharmacotherapy
management.
Specific
yet
be
developed,
but
some
show
potential
benefits,
such
inhibitors
Bruton's
Tyrosine
Kinase,
IL-4
IL-13.
Future
prevent
symptoms,
long-term
benefits
after
discontinuing
concomitant
disorders.
Journal of Tissue Engineering,
Год журнала:
2025,
Номер
16
Опубликована: Янв. 1, 2025
Atopic
dermatitis
(AD)
is
a
chronic
relapsing
dermatosis
that
demands
new
therapies.
This
research
group
previously
developed
physically
extracted
adipose-derived
extracellular
matrix
named
adipose
collagen
fragments
(ACF),
which
was
determined
containing
massive
matrix-bound
adipokines
and
medicable
on
AD
through
intradermal
injection.
However,
problems
concerning
the
control
of
drug
release
inevitable
pain
caused
by
injection
hinder
application
ACF
in
clinics.
Microneedle
(MN)
rapid
developing
technique
for
precise
painless
transdermal
delivery.
Therefore,
dissolving
methacrylated
gelatin/hyaluronic
acid
MN
patch
loaded
with
this
study.
The
morphological
characteristics,
mechanical
properties,
penetration
ability,
as
well
biocompatibility
degradation
efficiency
ACF-MN
were
evaluated,
its
efficacy
ovalbumin-induced
mice
also
investigated.
exhibited
excellent
biocompatibility,
efficiency,
satisfying
murine
similar
fresh-made
ACF.
Furthermore,
RNA-Seq
combining
bioinformatics
performed
mechanism
exploration.
treatment
showed
comprehensive
via
restoring
inflammatory
dysregulation,
microbiota
imbalance,
skin
barrier
defects.
study
offered
novel
MN-based
ACF-bound
delivery
system
may
serve
promising
strategy
relieving
AD.
