Advancements in a novel model of autophagy and immune network regulation in radioresistance of cancer stem cells

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 179, С. 117420 - 117420

Опубликована: Сен. 9, 2024

Язык: Английский

---

Oncometabolites at the crossroads of genetic, epigenetic and ecological alterations in cancer

Cell Death and Differentiation, Год журнала: 2024, Номер unknown

Опубликована: Окт. 23, 2024

Abstract By the time a tumor reaches clinical detectability, it contains around 10 8 –10 9 cells. However, during formation, significant cell loss occurs due to death. In some estimates, could take up thousand generations, over ~ 20-year life-span of tumor, reach which would correspond “theoretical” generation ~10 30 These rough calculations indicate that cancers are under negative selection. The fact they thrive implies “evolve”, and their evolutionary trajectories shaped by pressure environment. Evolvability cancer is function its heterogeneity, be at genetic, epigenetic, ecological/microenvironmental levels [1]. principles were summarized in proposed classification Evo (evolutionary) Eco (ecological) indexes used label index addresses cell-autonomous heterogeneity (genetic/epigenetic). describes ecological landscape (non-cell-autonomous) terms hazards survival resources available. reciprocal influence components critical, as can trigger self-sustaining loops shape evolvability [2]. Among various hallmarks [3], metabolic alterations appear unique intersect with both components. This partly because altered metabolism leads accumulation oncometabolites. oncometabolites have traditionally been viewed mediators non-cell-autonomous microenvironment. now increasingly recognized inducers genetic epigenetic modifications. Thus, uniquely positioned crossroads cancer. this review, mechanisms action will summarized, together roles phenotypic evolvability. An perspective impact on natural history presented.

Язык: Английский

---

Crosstalk between ferroptosis and autophagy: broaden horizons of cancer therapy

Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)

Опубликована: Янв. 6, 2025

Ferroptosis and autophagy are two main forms of regulated cell death (RCD). is a newly identified RCD driven by iron accumulation lipid peroxidation. Autophagy self-degradation system through membrane rearrangement. regulates the metabolic balance between synthesis, degradation reutilization cellular substances to maintain intracellular homeostasis. Numerous studies have demonstrated that both ferroptosis play important roles in cancer pathogenesis therapy. We also found there intricate connections autophagy. In this article, we tried clarify how different kinds participate process sort out common regulatory pathways cancer. By exploring complex crosstalk autophagy, hope broaden horizons

Язык: Английский

---

Prognostic Value of PSMB5 and Correlations with LC3II and Reactive Oxygen Species Levels in the Bone Marrow Mononuclear Cells of Bortezomib-Resistant Multiple Myeloma Patients

Current Issues in Molecular Biology, Год журнала: 2025, Номер 47(1), С. 32 - 32

Опубликована: Янв. 6, 2025

Proteasome inhibitors (PIs) constitute the most common type of induction treatment for multiple myeloma. Interactions between proteasome, autophagy, and reactive oxygen species (ROS) have been shown in past, thus emphasizing need a better understanding underlying pathophysiology. For this study, bone marrow mononuclear cells from 110 myeloma patients were collected at different disease stages. PSMB5 LC3I/II protein levels determined using Western blot, proteasome proteolytic activity (PPA) with spectrofluorometry, ROS flow cytometry. accumulation was found to diminish after PI (p-value = 0.014), same pattern observed PPA < 0.001). Conversely, LC3II elevated both remission relapse compared baseline 0.041). Patients lower than 1.06 units had longer disease-free survival those values above (12.0 ± 6.7 vs. 36 12.1 months; p-value Median plasma significantly higher 0.001), implying poor prognosis. Overall, post-treatment reduction could indicate shift proteasomal autophagic degradation as main proteostatic mechanism, explaining resistance. The oxidative stress PI-treated possibly serve an additional compensatory mechanism.

Язык: Английский

---

Investigating the interaction between calcium signaling and ferroptosis for novel cancer treatment

Phytomedicine, Год журнала: 2025, Номер 137, С. 156377 - 156377

Опубликована: Янв. 6, 2025

Язык: Английский

---