Recent Developments in the Optical Control of Adrenergic Signaling
Medicinal Research Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 3, 2025
ABSTRACT
Adrenoceptors
(ARs)
play
a
vital
role
in
various
physiological
processes
and
are
key
therapeutic
targets.
The
advent
of
optical
control
techniques,
including
optogenetics
photopharmacology,
offers
the
potential
to
modulate
AR
signaling
with
precise
temporal
spatial
resolution.
In
this
review,
we
summarize
latest
advancements
signaling,
encompassing
optogenetics,
photocaged
compounds,
photoswitchable
compounds.
We
also
discuss
limitations
current
tools
provide
an
outlook
on
next
generation
optogenetic
photopharmacological
tools.
These
emerging
technologies
not
only
enhance
our
understanding
but
pave
way
for
developments.
Язык: Английский
Active Forms of Chemerin Are Elevated in Human and Mouse Ovarian Carcinoma
Biomedicines,
Год журнала:
2025,
Номер
13(4), С. 991 - 991
Опубликована: Апрель 18, 2025
Background:
Chemerin
is
a
small
adipokine
that
activated
and
inactivated
by
proteolysis
of
its
C-terminus
with
role
in
regulating
metabolism,
immunity,
inflammation.
Significant
levels
chemerin
are
found
circulation
ascitic
fluid
ovarian
carcinoma
patients.
Methods:
We
investigated
the
different
forms
three
cohorts:
people
BMI
<
25,
>
40,
ascites
ELISAs
specific
for
forms.
Ascites
from
mouse
model
were
also
analyzed,
was
compared
between
wild-type
chemerin-deficient
mice.
Results:
Conversion
plasma
to
serum
increased
processed
lower
increases
samples
25
than
40.
High
total
both
patients
who
had
mean
29
model.
In
mice
tumors
grew
slower
Conclusions:
Serum
has
more
active
irrespective
source.
contained
high
chemerin,
which,
based
on
data,
enhance
tumor
growth.
Язык: Английский