Sulforaphane and Brain Health: From Pathways of Action to Effects on Specific Disorders DOI Open Access
Jed W. Fahey, Hua Liu,

Holly Batt

и другие.

Nutrients, Год журнала: 2025, Номер 17(8), С. 1353 - 1353

Опубликована: Апрель 15, 2025

The brain accounts for about 2% of the body’s weight, but it consumes 20% energy at rest, primarily derived from ATP produced in mitochondria. thus has a high mitochondrial density its neurons because extensive demands maintaining ion gradients, neurotransmission, and synaptic activity. is also extremely susceptible to damage dysregulation caused by inflammation (neuroinflammation) oxidative stress. Many systemic challenges can be mitigated phytochemical sulforaphane (SF), which particularly important supporting function. SF or biogenic precursor glucoraphanin, broccoli seeds sprouts, confer neuroprotective cognitive benefits via diverse physiological biochemical mechanisms. able cross blood–brain barrier as well protect it, mitigates consequences destructive neuroinflammation. It protects against neurotoxic effects environmental pollutants, combats tissue cell wrought advanced glycation end products (detoxication), supports healthy glucose metabolism. These are applicable individuals all ages, developing brains periconception infancy, cognitively, developmentally, traumatically challenged brains, those later life who suffering with multiple chronic conditions including Parkinson’s Alzheimer’s diseases.

Язык: Английский

Role in Preventing Alcoholic Liver Disease Progression: A Comparative Study of Whole-Component Finger Citron Essential Oil and Its Major Component D-Limonene DOI Open Access
J. Chen,

Genghua Ou,

Wenting Gu

и другие.

Nutrients, Год журнала: 2025, Номер 17(7), С. 1255 - 1255

Опубликована: Апрель 3, 2025

Background/Objectives: Chronic alcohol overconsumption triggers liver injury, and therapeutic strategies targeting alcohol-triggered oxidative stress hepatic inflammatory responses represent potential approaches to ameliorating alcohol-related hepatotoxicity. This study aimed determine the hepatoprotective activity of finger citron essential oil (FCEO) in alcoholic disease (ALD)-afflicted rats explore its underlying mechanisms. In order identify effective components, we compared effects FCEO D-limonene. Methods: The regulatory on metabolic enzymes were systematically evaluated through vitro experiments. vivo studies conducted investigate compare Staining methods, assay kits, Western Blot used roles D-limonene ALD rats. Results: We found that downregulated phase I upregulated II Buffalo Rat Liver-3A (BRL-3A) cells. and/or intervention reduced transaminase levels effectively alleviated cell infiltration lipid droplet accumulation their tissue. Additionally, played a role inflammation-related pathways such as MAPK/Nrf2 NF-κB/AMPK pathways. was superior an antioxidant alleviating injury. Conclusions: revealed alleviative mechanisms demonstrating better efficacy monomer, thus providing strategy for development utilization resources.

Язык: Английский

Процитировано

0
The Ancestral KEAP1-NRF Pathway in Amphioxus Branchiostoma japonicum: Implications for the Evolution of Antioxidant Defense System DOI Open Access
Weichen Li,

Xiaoqian Liang,

Keyu Xiang

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 3427 - 3427

Опубликована: Апрель 6, 2025

The Kelch-like ECH-associated protein 1 (KEAP1)/Nuclear factor E2-related 2 (NRF2) pathway is a key mechanism that responds to oxidative stress and xenobiotic stimuli in vertebrates. However, knowledge of its evolutionary origins remains limited. In this study, we identify the ancestral homologues KEAP1 NRF (BjKEAP1 BjNRF) cephalochordate amphioxus (Branchiostoma japonicum). BjNRF uniquely combines feature domains vertebrates NRF1 NRF2, marking it as an intermediate. High expression levels Bjkeap1 Bjnrf gill, hepatic cecum, intestine highlight their roles environmental defense at interface tissues. Functional studies reveal BjKEAP1 regulates cytoplasmic localization BjNRF. Typical NRF2 activator sulforaphane (SFN) induces nuclear translocation significantly elevates transcriptional phase II detoxification enzymes. Moreover, exposure toxin Benzo[a]pyrene (BaP) activates response system. These findings bridge critical gaps our understanding basal chordates offer new insights into trajectory KEAP1-NRF Furthermore, study highlights crucial implications for conservation deteriorating marine environments.

Язык: Английский

Процитировано

0
Sulforaphane and Brain Health: From Pathways of Action to Effects on Specific Disorders DOI Open Access
Jed W. Fahey, Hua Liu,

Holly Batt

и другие.

Nutrients, Год журнала: 2025, Номер 17(8), С. 1353 - 1353

Опубликована: Апрель 15, 2025

The brain accounts for about 2% of the body’s weight, but it consumes 20% energy at rest, primarily derived from ATP produced in mitochondria. thus has a high mitochondrial density its neurons because extensive demands maintaining ion gradients, neurotransmission, and synaptic activity. is also extremely susceptible to damage dysregulation caused by inflammation (neuroinflammation) oxidative stress. Many systemic challenges can be mitigated phytochemical sulforaphane (SF), which particularly important supporting function. SF or biogenic precursor glucoraphanin, broccoli seeds sprouts, confer neuroprotective cognitive benefits via diverse physiological biochemical mechanisms. able cross blood–brain barrier as well protect it, mitigates consequences destructive neuroinflammation. It protects against neurotoxic effects environmental pollutants, combats tissue cell wrought advanced glycation end products (detoxication), supports healthy glucose metabolism. These are applicable individuals all ages, developing brains periconception infancy, cognitively, developmentally, traumatically challenged brains, those later life who suffering with multiple chronic conditions including Parkinson’s Alzheimer’s diseases.

Язык: Английский

Процитировано

0