Frontiers in Immunology,
Год журнала:
2022,
Номер
13
Опубликована: Июнь 6, 2022
The
molecular
mechanisms
of
osteoarthritis,
the
most
common
chronic
disease,
remain
unexplained.
This
study
aimed
to
use
bioinformatic
methods
identify
key
biomarkers
and
immune
infiltration
in
osteoarthritis.
Gene
expression
profiles
(GSE55235,
GSE55457,
GSE77298,
GSE82107)
were
selected
from
Expression
Omnibus
database.
A
protein-protein
interaction
network
was
created,
functional
enrichment
analysis
genomic
performed
using
Ontology
(GO)
Kyoto
Encyclopedia
Genes
Genome
(KEGG)
databases.
Immune
cell
between
osteoarthritic
tissues
control
analyzed
CIBERSORT
method.
Identify
patterns
ConsensusClusterPlus
package
R
software
a
consistent
clustering
approach.
Molecular
biological
investigations
discover
important
genes
cartilage
cells.
total
105
differentially
expressed
identified.
Differentially
enriched
immunological
response,
chemokine-mediated
signaling
pathway,
inflammatory
response
revealed
by
GO
KEGG
Two
distinct
(ClusterA
ClusterB)
identified
ConsensusClusterPlus.
Cluster
patients
had
significantly
lower
resting
dendritic
cells,
M2
macrophages,
mast
activated
natural
killer
cells
regulatory
T
than
B
patients.
levels
TCA1,
TLR7,
MMP9,
CXCL10,
CXCL13,
HLA-DRA,
ADIPOQSPP1
higher
IL-1β-induced
group
osteoarthritis
an
vitro
qPCR
experiment.
Explaining
differences
normal
will
contribute
understanding
development
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(4), С. 1989 - 1989
Опубликована: Фев. 11, 2022
Aging
is
the
greatest
risk
factor
for
late-onset
Alzheimer’s
disease
(LOAD),
which
accounts
>95%
of
(AD)
cases.
The
mechanism
underlying
aging-related
susceptibility
to
LOAD
unknown.
Cellular
senescence,
a
state
permanent
cell
growth
arrest,
believed
contribute
importantly
aging
and
diseases,
including
AD.
Senescent
astrocytes,
microglia,
endothelial
cells,
neurons
have
been
detected
in
brain
AD
patients
animal
models.
Removing
senescent
cells
genetically
or
pharmacologically
ameliorates
β-amyloid
(Aβ)
peptide
tau-protein-induced
neuropathologies,
improves
memory
model
mice,
suggesting
pivotal
role
cellular
senescence
pathophysiology.
Nonetheless,
although
accumulated
evidence
supports
AD,
mechanisms
that
promote
how
neuropathophysiology
remain
largely
This
review
summarizes
recent
advances
this
field.
We
believe
removal
represents
promising
approach
toward
effective
treatment
such
as
Inflammation and Regeneration,
Год журнала:
2022,
Номер
42(1)
Опубликована: Апрель 2, 2022
Abstract
Cellular
senescence
is
a
state
of
irreversible
cell
cycle
arrest
that
can
be
induced
by
variety
potentially
oncogenic
stimuli,
including
DNA
damage.
Hence,
has
long
been
considered
to
suppress
tumorigenesis,
acting
as
guardian
homeostasis.
However,
recent
studies
have
revealed
senescent
cells
exhibit
the
secretion
series
inflammatory
cytokines,
chemokines,
growth
factors,
and
matrix
remodeling
factors
alter
local
tissue
environment
contribute
chronic
inflammation
cancer.
This
phenotype
termed
senescence-associated
secretory
(SASP)
observed
not
only
in
cultured
vitro
but
also
vivo
.
Recently,
physiological
pathological
roles
SASP
increasingly
clarified.
Notably,
several
reported
intrinsic
mechanism
factor
production
predominantly
mediated
through
activation
cGAS-STING
(cyclic
GMP-AMP
synthase-stimulator
interferon
genes)
pathway
aberrantly
accumulated
fragments
from
nucleus
cells.
In
contrast,
various
extrinsic
triggers
exist
vivo,
for
example,
induction
hepatic
stellate
tumor
microenvironment
obesity-associated
liver
cancer
translocated
gut
microbial
metabolites.
strategy
elimination
(senolysis)
attracted
increasing
attention.
Thus,
role
effects
outcomes
senolysis
will
discussed
this
review.
Chemical Reviews,
Год журнала:
2024,
Номер
124(5), С. 2699 - 2804
Опубликована: Фев. 29, 2024
The
ability
to
gain
spatiotemporal
information,
and
in
some
cases
achieve
control,
the
context
of
drug
delivery
makes
theranostic
fluorescent
probes
an
attractive
intensely
investigated
research
topic.
This
interest
is
reflected
steep
rise
publications
on
topic
that
have
appeared
over
past
decade.
Theranostic
probes,
their
various
incarnations,
generally
comprise
a
fluorophore
linked
masked
drug,
which
released
as
result
certain
stimuli,
with
both
intrinsic
extrinsic
stimuli
being
reported.
release
then
signaled
by
emergence
signal.
Importantly,
use
appropriate
fluorophores
has
enabled
not
only
this
emerging
fluorescence
marker
for
but
also
provided
modalities
useful
photodynamic,
photothermal,
sonodynamic
therapeutic
applications.
In
review
we
highlight
recent
work
particular
focus
are
activated
tumor
microenvironments.
We
summarize
efforts
develop
other
applications,
such
neurodegenerative
diseases
antibacterials.
celebrates
diversity
designs
reported
date,
from
discrete
small-molecule
systems
nanomaterials.
Our
aim
provide
insights
into
potential
clinical
impact
still-emerging
direction.
Cancer Cell,
Год журнала:
2023,
Номер
41(7), С. 1242 - 1260.e6
Опубликована: Июнь 1, 2023
The
accumulation
of
senescent
cells
in
the
tumor
microenvironment
can
drive
tumorigenesis
a
paracrine
manner
through
senescence-associated
secretory
phenotype
(SASP).
Using
new
p16-FDR
mouse
line,
we
show
that
macrophages
and
endothelial
are
predominant
cell
types
murine
KRAS-driven
lung
tumors.
Through
single
transcriptomics,
identify
population
tumor-associated
express
unique
array
pro-tumorigenic
SASP
factors
surface
proteins
also
present
normal
aged
lungs.
Genetic
or
senolytic
ablation
cells,
macrophage
depletion,
result
significant
decrease
burden
increased
survival
cancer
models.
Moreover,
reveal
presence
with
features
human
pre-malignant
lesions,
but
not
adenocarcinomas.
Taken
together,
our
results
have
uncovered
important
role
initiation
progression
cancer,
highlighting
potential
therapeutic
avenues
preventative
strategies.
Stem Cell Research & Therapy,
Год журнала:
2022,
Номер
13(1)
Опубликована: Авг. 20, 2022
Abstract
Mesenchymal
stem
cells
(MSCs),
coming
from
a
wide
range
of
sources,
have
multi-directional
differentiation
ability.
MSCs
play
vital
roles
in
immunomodulation,
hematopoiesis
and
tissue
repair.
The
microenvironment
often
refers
to
the
intercellular
matrix,
other
cells,
cytokines
humoral
components.
It
is
also
place
for
cells’
interaction.
stability
pivotal
maintaining
cell
proliferation,
differentiation,
metabolism
functional
activities.
Abnormal
changes
components
can
interfere
functions.
In
some
diseases,
interact
with
accelerate
disease
progression.
This
review
will
discuss
characteristics
their
microenvironment,
as
well
interaction
between
disease.
