Recent advances in gut microbiota and thyroid disease: pathogenesis and therapeutics in autoimmune, neoplastic, and nodular conditions DOI Creative Commons
Lihua Fang, Jie Ning

Frontiers in Cellular and Infection Microbiology, Год журнала: 2024, Номер 14

Опубликована: Дек. 24, 2024

This review synthesizes key findings from the past five years of experimental literature, elucidating gut microbiome’s significant influence on pathogenesis thyroid diseases. A pronounced shift in microbiota composition has been consistently observed, with a reduction bacteria such as Bifidobacterium , Bacillaceae Megamonas and Clostridium notable increase bacteria, including Bacteroides Proteobacteria Actinobacteria Desulfobacterota Klebsiella . These alterations are implicated development progression diseases by impacting metabolic pathways bile acid cytokine production, decrease short-chain fatty acids (SCFAs) that crucial for immune regulation hormone homeostasis. The also highlights therapeutic implications probiotics managing conditions. Evidence suggests probiotic adjunct therapy can modulate microbiota, leading to improvements function patient outcomes. use specific strains, Lactiplantibacillus plantarum 299v longum demonstrated potential enhancing effects traditional treatments possibly restoring balanced microbiota. Notably, fecal transplantation (FMT) emerged promising intervention Graves’ Disease (GD), demonstrating recalibrate thereby influencing neurotransmitters trace elements via gut-brain gut-thyroid axes. integration microbiome-based therapies is anticipated usher new era personalized disease management, offering more nuanced approach care. By integrating this body work, offers an innovative perspective broad impact applications probiotics.

Язык: Английский

KEY DATA FROM THE 2024 EUROPEAN THYROID ASSOCIATION ANNUAL MEETING: AUTOIMMUNE THYROID DISEASES DOI
Solange Grunenwald, Philippe Caron

Annales d Endocrinologie, Год журнала: 2025, Номер 86(2), С. 101683 - 101683

Опубликована: Янв. 11, 2025

Язык: Английский

Процитировано

0
Global Burden and Trend of Thyroid Cancer in Children and Adolescents Aged 0 – 19 Years: A Systematic Analysis of the Global Burden of Diseases Study 1990 – 2021 DOI

Wenyi Zhang,

Jiabei He,

Weiqiong Jin

и другие.

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Role of FOXP3 (rs3761548) Polymorphism in Modulating FOXP3 Protein Level in Iraqi Patients with Thyroid Disorder DOI Creative Commons

Basma Ahmed Muayad,

Hamsa Ahmed Jassim

Al-Rafidain Journal of Medical Sciences ( ISSN 2789-3219 ), Год журнала: 2025, Номер 8(1), С. 208 - 214

Опубликована: Март 16, 2025

Background: Thyroid disorders are a major clinical concern that negatively impacts the thyroid gland. issues have been connected to FOXP3 gene, which is an important immune system regulator. protein levels can be affected by genetic differences, may impair regulatory T-cell activity and exacerbate immunological abnormalities. Objectives: To investigate influence of gene polymorphisms on circulating their association with dysfunction. Methods: This study included 100 patients 50 healthy controls. function was assessed measuring serum T3, T4, TSH using Cobas analyzer. Serum were quantified ELISA. Genomic DNA extracted analyzed for variations PCR sequencing. Results: No significant differences observed in T3 T4 between However, significantly elevated patient group. lower compared The distribution three genotypes (AA, AC, CC) did not differ Individuals heterozygous (AC) genotype exhibited higher other two genotypes. Conclusions: had reduced FOXP3, indicate disease impaired immunity. emphasizes complicated interaction environmental factors, even if it could identify obvious connection rs3761548 variation.

Язык: Английский

Процитировано

0
Hashimoto’s thyroiditis– What’s in a name? DOI

Mikhail Khachaturov,

Dimitrios G. Goulis,

Petros Perros

и другие.

HORMONES, Год журнала: 2025, Номер unknown

Опубликована: Апрель 2, 2025

Язык: Английский

Процитировано

0
Microbiota and Recurrent Pregnancy Loss (RPL); More than a Simple Connection DOI Creative Commons
Jenny Garmendia, Claudia Valentina De Sanctis, Marián Hajdúch

и другие.

Microorganisms, Год журнала: 2024, Номер 12(8), С. 1641 - 1641

Опубликована: Авг. 10, 2024

Recurrent Pregnancy Loss (RPL) affects 1–2% of women, and its triggering factors are unclear. Several studies have shown that the vaginal, endometrial, gut microbiota may play a role in RPL. A decrease quantity Lactobacillus crispatus local has been associated with an increase (vaginal endometrial) inflammatory response immune cell activation leads to pregnancy loss. The be triggered by gram-negative bacteria, lipopolysaccharides (LPS), viral infections, mycosis, or atypia (tumor growth). Bacterial structures metabolites produced could involved modulation responsible for molecular mimicry. Gut metabolic products amount circulating pro-inflammatory lymphocytes, which, turn, will migrate into vaginal endometrial tissues. Local Th1 Th17 subpopulations Treg tolerogenic NK cells accountable modulate response, increasing success. Analyzing necessary characterize some RPL patients. Although oral supplementation probiotics not modify microbiota, it benefit transplantation vagina enhance required achieve normal pregnancy. effect hormone stimulation progesterone maintain early on adequately studied, more research is needed this area. Well-designed clinical trials ascertain

Язык: Английский

Процитировано

1
Exploring the Microbiome of Fermented Soy Products: Implications for Gut Health in China DOI

Xuesong Xiang,

Yingying Li, Junbin Ye

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Сен. 27, 2024

Abstract Background: Fermented foods have a long history in China, and they continue to be widely consumed today. recently been reported as pivotal approach restoring gut microbial diversity are recommended by the International Scientific Association for Probiotics Prebiotics inclusion dietary guidelines. However, there potential safety concerns associated with fermented foods, such transfer of antibiotic resistance genes human gut. This underscores need deeper understanding communities additional data facilitate health risk assessments. Results: In this study, we employed shotgun metagenomic analysis investigate microbiota three commonly soy products China compared them Chinese population. Our findings revealed significant differences both composition functions among these products. Intriguingly, network an antagonistic interaction between beneficial species Bacillales Lactobacillales, potentially harmful Enterobacterales. examining microbiota, identified high prevalence bacteria from Enterobacterales order, which were also found amounts foods. Using genome-level strain-level analyses, hypothesize that may serve source bacteria, Klebsiella pneumoniae quasipneumoniae, microbiota. Horizontal gene highlighted numerous microbes those microbiome. Conclusions: While is substantial evidence supporting benefits consuming our research highlights important concerns. Notably, could increase exposure pathogenic microorganisms transmission. accentuates enhanced monitoring quality control measures

Язык: Английский

Процитировано

1
Uncovering a Causal Connection between Gut Microbiota and Six Thyroid Diseases: A Two-Sample Mendelian Randomization Study DOI Creative Commons
Jiahao Chen,

Yu Wang,

Hang Yao

и другие.

Biology, Год журнала: 2024, Номер 13(9), С. 714 - 714

Опубликована: Сен. 11, 2024

Recent studies have established associations between the gut microbiota (GM) and thyroid diseases (TDs). However, their causal relationships remain elusive.

Язык: Английский

Процитировано

0
The Gut Microbiome and Autoimmunity DOI
Mike May

Inside Precision Medicine, Год журнала: 2024, Номер 11(5), С. 12 - 15

Опубликована: Окт. 1, 2024

Язык: Английский

Процитировано

0
Recent advances in gut microbiota and thyroid disease: pathogenesis and therapeutics in autoimmune, neoplastic, and nodular conditions DOI Creative Commons
Lihua Fang, Jie Ning

Frontiers in Cellular and Infection Microbiology, Год журнала: 2024, Номер 14

Опубликована: Дек. 24, 2024

This review synthesizes key findings from the past five years of experimental literature, elucidating gut microbiome’s significant influence on pathogenesis thyroid diseases. A pronounced shift in microbiota composition has been consistently observed, with a reduction bacteria such as Bifidobacterium , Bacillaceae Megamonas and Clostridium notable increase bacteria, including Bacteroides Proteobacteria Actinobacteria Desulfobacterota Klebsiella . These alterations are implicated development progression diseases by impacting metabolic pathways bile acid cytokine production, decrease short-chain fatty acids (SCFAs) that crucial for immune regulation hormone homeostasis. The also highlights therapeutic implications probiotics managing conditions. Evidence suggests probiotic adjunct therapy can modulate microbiota, leading to improvements function patient outcomes. use specific strains, Lactiplantibacillus plantarum 299v longum demonstrated potential enhancing effects traditional treatments possibly restoring balanced microbiota. Notably, fecal transplantation (FMT) emerged promising intervention Graves’ Disease (GD), demonstrating recalibrate thereby influencing neurotransmitters trace elements via gut-brain gut-thyroid axes. integration microbiome-based therapies is anticipated usher new era personalized disease management, offering more nuanced approach care. By integrating this body work, offers an innovative perspective broad impact applications probiotics.

Язык: Английский

Процитировано

0